Safety, tolerability, and efficacy of a widely available nusinersen program for Polish children with Spinal Muscular Atrophy

Autor: Katarzyna Kotulska, Dariusz Chmielewski, Maria Mazurkiewicz-Bełdzińska, Katarzyna Tomaszek, Katarzyna Pierzchlewicz, Daniel Rabczenko, Łukasz Przysło, Agnieszka Biedroń, Elżbieta Czyżyk, Barbara Steinborn, Jerzy Pietruszewski, Leszek Boćkowski, Dorota Cichosz, Magdalena Dudzińska, Elżbieta Gadowska, Elżbieta Młynarczyk, Mirosław Jasiński, Anna Masztalerz, Agnieszka Kempisty, Anna Kostera-Pruszczyk

Publikováno v: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 39

Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder with limited treatment options. Nusinersen is the first disease-modifying therapy to treat children and adults with SMA. This study aimed to review the safety, tolerability, and ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497be266ea2aec874c6b11707533c5cd
https://pubmed.ncbi.nlm.nih.gov/35738181

Anti-inflammatory plasma cytokines in children and adolescents with Down syndrome.

Autor: Krzysztof Sendrowski, Wojciech Sobaniec, Leszek Boćkowski, Joanna Smigielska-Kuzia, Beata Zelazowska-Rutkowska, Magdalena Cholewa

Publikováno v: Folia Histochemica et Cytobiologica, Vol 48, Iss 4, Pp 667-670 (2011)

Cytokines participate in many physiological processes including the regulation of immune and inflammatory responses. Production of some important cytokines in children with Down syndrome (DS) is depressed or increased. In this study we analysed the s

Externí odkaz: https://doaj.org/article/53d5f1e66f5f4e91a4783efb12dd07f7

Antioxidant enzymes and lipid peroxides in children with Down syndrome

Autor: Bozena Zawada, Leszek Boćkowski, Joanna Śmigielska-Kuzia, Grażyna Paszko, Wojciech Kułak, Wojciech Sobaniec

Publikováno v: Scopus-Elsevier

Impaired antioxidant mechanisms lead to an increase in free radicals and may induce a number of pathophysiological processes resulting in cell injury. Thus, any abnormality in antioxidant systems could affect neurodevelopmental processes and could ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354ef8b3219a1719059e72d31f0ae31c
https://doi.org/10.1055/s-0035-1557373

Anti-inflammatory plasma cytokines in children and adolescents with Down syndrome

Autor: Leszek Boćkowski, Wojciech Sobaniec, Krzysztof Sendrowski, Joanna Smigielska-Kuzia, Magdalena Cholewa, Beata Zelazowska-Rutkowska

Publikováno v: Folia Histochemica et Cytobiologica, Vol 48, Iss 4, Pp 667-670 (2011)
Folia Histochemica et Cytobiologica, Vol 48, Iss 4, Pp 667-670 (2010)

Cytokines participate in many physiological processes including the regulation of immune and inflammatory responses. Production of some important cytokines in children with Down syndrome (DS) is depressed or increased. In this study we analysed the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803880f5a0a0822140a74ecd4748ba8c
http://czasopisma.viamedica.pl/fhc/article/view/4165

A volumetric magnetic resonance imaging study of brain structures in children with Down syndrome

Autor: Joanna Śmigielska-Kuzia, Magdalena Cholewa, Leszek Boćkowski, Krzysztof Sendrowski, Wojciech Sobaniec, Adam Lukasiewicz, Urszula Lebkowska, Beata Olchowik

Publikováno v: ResearcherID

Background and purpose Down syndrome (DS) is the most common genetic cause of mental retardation with deficits in language and memory. Mental retardation of varying degrees is the most consistent feature of DS. The objective of this study was to use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61529e9256d97aa5231dccfff8d92528
https://doi.org/10.1016/s0028-3843(14)60107-9