Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Lester G. Sultatos"'
Autor:
Vishwendra Patel, Anne Oh, Antanina Voit, Lester G Sultatos, Gopal J Babu, Brenda A Wilson, Mengfei Ho, Joseph J McArdle
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e110571 (2014)
Recent studies demonstrate reduced motor-nerve function during autoimmune muscle-specific tyrosine kinase (MuSK) myasthenia gravis (MG). To further understand the basis of motor-nerve dysfunction during MuSK-MG, we immunized female C57/B6 mice with p
Externí odkaz:
https://doaj.org/article/86c5f20406044c8abc76c0b966bd74ae
Autor:
Joseph J. McArdle, R. E. Clutton, Robert Chang-Chih Chou, Richard R. Ribchester, Michael Eddleston, Kosala N. Dissanayake, Filip Margetiny, Adrian Thompson, Lester G. Sultatos, Scott McKinnon, Charlotte Davie, Vishwendra Patel
Publikováno v:
Clinical toxicology (Philadelphia, Pa.). 59(12)
Ingestion of agricultural organophosphorus insecticides is a significant cause of death in rural Asia. Patients often show acute respiratory failure and/or delayed, unexplained signs of neuromuscular paralysis, sometimes diagnosed as "Intermediate Sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5226bea58c48e076f540978eed0ce61
https://pubmed.ncbi.nlm.nih.gov/33988053
https://pubmed.ncbi.nlm.nih.gov/33988053
Autor:
Steven D. Hartson, Lester G. Sultatos, Jing Liu, Ashish Ranjan, Stephen Brimijoin, Carey Pope, Nicholas Flynn, Joshua D. Ramsey, Kirstin Hester, Liyi Geng
Publikováno v:
Chemico-Biological Interactions. 275:86-94
We previously reported that recombinant human butyrylcholinesterase (rhBChE) complexed with a series of copolymers of poly- l -lysine (PLL) with grafted (polyethylene) glycol (PEG) (i.e., PLL-g-PEG) showed reduced catalytic activity but relatively si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52d748d0ead752c6344ceda5ecf6f41
https://doi.org/10.1016/j.cbi.2017.07.019
https://doi.org/10.1016/j.cbi.2017.07.019
Autor:
Joseph G. Potian, Vanessa H. Routh, Kormakur Hognason, Baskaran Thyagarajan, Lester G. Sultatos, Nizar Souayah, Carmen C. Garcia, Joseph J. McArdle
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 303:E551-E561
Diabetic neuropathy is associated with functional and morphological changes of the neuromuscular junction (NMJ) associated with muscle weakness. This study examines the effect of type 1 diabetes on NMJ function. Swiss Webster mice were made diabetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe5dfb81dbe319c547288eb12a4a642
https://doi.org/10.1152/ajpendo.00622.2011
https://doi.org/10.1152/ajpendo.00622.2011
Publikováno v:
Toxicology and Applied Pharmacology. 241:135-142
Acetylcholinesterase (EC 3.1.1.7) and butyrylcholinesterase (EC 3.1.1.8) are enzymes that belong to the superfamily of α/β-hydrolase fold proteins. While they share many characteristics, they also possess many important differences. For example, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc6378bc96d1faeeaa3280e08bd387f
https://doi.org/10.1016/j.taap.2009.08.014
https://doi.org/10.1016/j.taap.2009.08.014
Autor:
Lester G. Sultatos, Axay Patel, Joseph J. McArdle, Vishwendra Patel, Pascal Sonnet, Alexandra Dassonville-Klimpt
Publikováno v:
The FASEB Journal. 29
Racemic mefloquine activates spontaneous vesicle release (SVR) from motor nerve endings and inhibits endplate acetylcholinesterase (AChE). Such cholinergic effects may reduce mefloquine's safety as an antimalarial drug. We tested the hypothesis that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04cd579a3f8c600011719469c976d9c1
https://doi.org/10.1096/fasebj.29.1_supplement.lb40
https://doi.org/10.1096/fasebj.29.1_supplement.lb40
Publikováno v:
Human and Ecological Risk Assessment: An International Journal. 10:91-98
The purpose of this study was to investigate how variability in pharmacokinetic parameters influences the determination of occupational exposure limits (OEL) for pharmaceutical compounds in potentially susceptible subpopulations. A compartmental phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10d98b07993e593be62740b17bb89830
https://doi.org/10.1080/10807030490280981
https://doi.org/10.1080/10807030490280981
Autor:
Lester G. Sultatos, Ahmed Kousba
Publikováno v:
Toxicology Letters. 133:153-159
A tissue/blood partition coefficient, defined as the ratio of tissue chemical concentration to that of the venous outflow of the tissue when at equilibrium, is an important parameter required for physiological based pharmacokinetic models. While many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f26048a95d9711ed05131899f44ffb9
https://doi.org/10.1016/s0378-4274(02)00131-5
https://doi.org/10.1016/s0378-4274(02)00131-5
Autor:
Joseph J. McArdle, Vishwendra Patel, Anne Oh, Brenda A. Wilson, Mengfei Ho, Gopal J. Babu, Antanina Voit, Lester G. Sultatos
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 12, p e110571 (2014)
PLoS ONE, Vol 9, Iss 12, p e110571 (2014)
Recent studies demonstrate reduced motor-nerve function during autoimmune muscle-specific tyrosine kinase (MuSK) myasthenia gravis (MG). To further understand the basis of motor-nerve dysfunction during MuSK-MG, we immunized female C57/B6 mice with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c13277f601b5620bc548ba078b4d97b
https://pubmed.ncbi.nlm.nih.gov/25438154
https://pubmed.ncbi.nlm.nih.gov/25438154
Autor:
Sonia Ramos, Lester G. Sultatos
Publikováno v:
Toxicology. 131:155-167
The majority of insecticides currently in use throughout the world belong to the class of the organophosphorus insecticides. Many of these compounds, such as the phosphorothioate insecticides, exert their mammalian toxicity only after undergoing meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223d2ee06151b97529afce751cceeb89
https://doi.org/10.1016/s0300-483x(98)00125-5
https://doi.org/10.1016/s0300-483x(98)00125-5