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Comment to: Böhlen et al. 'Normal tissue sparing by FLASH as a function of single fraction dose: A quantitative analysis'

Autor: Horst, F. E., Brand, M., Hans, S., Karsch, L., Leßmann, E., Löck, S., Schürer, M., Pawelke, J., Beyreuther, E.

Publikováno v: International Journal of Radiation Oncology Biology Physics 115(2023)4, 1006-1007

Böhlen et al. [1] recently proposed a model that describes the magnitude of the normal tissue sparing Flash effect as a function of dose based on available in vivo data. The newly introduced flash modifying factor FMF translates doses applied at ult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::c1522233474b649cf8542445a1089a65
https://www.hzdr.de/publications/Publ-35212-1

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Tumor irradiation in mice with a laser-accelerated proton beam

Publikováno v: Nature Physics 18(2022), 316-322
APS DPP, 18.10.2022, Spokane, USA

Recent oncological studies identified beneficial properties of radiation applied at ultra-high dose rates several orders of magnitude higher than the clinical standard of the order of Gy/min. Sources capable of providing these ultra-high dose rates a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::985b52d9e92eb51f66c510d035f32c9a
https://www.hzdr.de/publications/Publ-33044-1

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Laser-plasma based proton accelerators for small animal pre-clinical radiation research

Publikováno v: 5th Conference on Smal animal Precision Image-Guided Radiotherapy, 21.-23.03.2022, München, Deutschland

Laser-plasma based proton accelerators as a novel accelerator technology have matured to a level at which laboratory-scale setups for the emerging topic of image-guided precision small animal irradiation studies come into reach [Bra2019]. Providing a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::70f2c6c36e5a9bf75dbca34a72e03c81
https://www.hzdr.de/publications/Publ-36188-1

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Source Data: Tumour irradiation in mice with a laser-accelerated proton beam (Open Access)

Publikováno v: Publication date: 2022-03-11 Open accessDOI: 10.14278/rodare.1128Versions: 10.14278/rodare.1477 | 10.14278/rodare.1476 | 10.14278/rodare.1129License: CC-BY-4.0

Source data for all figures of publication: "Tumor irradiation in mice with a laser-accelerated proton beam". The folder structure is adapted to match thefigures in the publication.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::3d1ad288d2cabb2b0f9242c68b952599
https://www.hzdr.de/publications/Publ-33047-1

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Ultra-high dose rate radiobiology and dosimetry at the laser-driven proton accelerator Draco-PW

Autor: Brack, F.-E., Reimold, M., Kroll, F., Beyreuther, E., Karsch, L., Kraft, S., Leßmann, E., Pawelke, J., Schlenvoigt, H.-P., Schramm, U., Umlandt, M. E. P., Ziegler, T., Zeil, K., Metzkes-Ng, J.

Publikováno v: Flash Radiotherapy and Particle Therapy Conference-FRPT 2022, 29.11.-02.12.2022, Barcelona, Spanien

Background and Aims Laser-plasma accelerators (LPA) are a viable addition to the ultra-high dose rate accelerator portfolio, as they generate extremely intense proton bunches of several 10 MeV kinetic energy. Efficiently transported and spectrally sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::d276626397c8b3a48138e39809719d39
https://www.hzdr.de/publications/Publ-36207-1

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Systematic proton Flash experiments with zebrafish embryo

Autor: Beyreuther, E., Brack, F.-E., Hans, S., Horst, F. E., Jansen, J., Karsch, L., Leßmann, E., Löck, S., Metzkes-Ng, J., Pawelke, J., Reimold, M., Seco, J., Schramm, U., Szabo, R., Zeil, K.

Publikováno v: 2nd Flash Radiotherapy and Particle Therapy Conference (FRPT 2022), 30.11.-02.12.2022, Barcelona, Spain

Background and Aims The Flash effect, i.e. the radiobiological observation of normal tissue sparing but efficient tumor killing by ultra-high dose rate (UHDR) irradiation, promise great benefits for cancer patient treatment. The translation process o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::befe083588e9518916ea6dcd20c6aa77
https://www.hzdr.de/publications/Publ-36085-1

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Beam pulse structure affects the magnitude of Flash effect in zebrafish embryo

Autor: Beyreuther, E., Pawelke, J., Brand, M., Hans, S., Hideghety, K., Jansen, J., Karsch, L., Leßmann, E., Löck, S., Schürer, M., Seco, J., Szabo, E. R., Schramm, U.

Publikováno v: ESTRO 2022, 06.-10.05.2022, Copenhagen, Denmark
Radiotherapy and Oncology 170(2022), S69-S70

Purpose/Objective In a previous experiment at the HZDR research electron accelerator ELBE high mean dose rates of 105 Gy/s in combination with partial oxygen pressure below 5 mmHg protect zebrafish embryo from radiation damage compared to continuous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2439cd2f3467d89b7fcc05f707e83fac
https://www.hzdr.de/publications/Publ-36082-1

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Cell irradiation setup and dosimetry for radiobiological studies at ELBE

Autor: Zeil, K., Beyreuther, E., Lessmann, E., Wagner, W., Pawelke, J.

Publikováno v: In Nuclear Inst. and Methods in Physics Research, B 2009 267(14):2403-2410

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