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pro vyhledávání: '"Lesopitron"'
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Autor:
Gaston Marion-Landais, Giedra M Campbell, Michael F. Murphy, Anna Fresquet, Frederick J. Carter, Antonio Lloret, Mariano Sust
Publikováno v:
Annals of Pharmacotherapy. 34:147-153
OBJECTIVE: To compare the relative efficacy and safety of lesopitron 40–80 mg/d versus lorazepam 2–4 mg/d and placebo in a subgroup of patients with anxiety history taken from a larger study of patients with a primary diagnosis of generalized anx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e5bcf10c4bb1213f108b7458d69b9d
https://doi.org/10.1345/aph.19041
https://doi.org/10.1345/aph.19041
Publikováno v:
Neuropharmacology. 38:525-532
In line with the idea that cholecystokinin (CCK) is involved in anxiety-related behaviours, previous investigations showed that stressful conditions and an 'anxiogenic' drug, yohimbine, increased the cortical release of CCK like-material (CCKLM) in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bfe4ec02772dc25c566d932d7ea698
https://doi.org/10.1016/s0028-3908(98)00209-3
https://doi.org/10.1016/s0028-3908(98)00209-3
Autor:
Brenda Costall, Robert J. Naylor
Publikováno v:
British Journal of Pharmacology. 122:1105-1118
1 The ability of 5-HT2 and 5-HT4 receptor antagonists to modify the disinhibitory profile of diazepam and other agents was investigated in male BKW mice in the light/dark test box. 2 The 5-HT2A/2B/2C receptor antagonists ritanserin, MDL11939 and RP62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3285ce4a46c8aefb82d1392f43a2eee6
https://doi.org/10.1038/sj.bjp.0701513
https://doi.org/10.1038/sj.bjp.0701513
Publikováno v:
Brain Research. 742:141-148
We have studied the effects of the neuroleptic haloperidol and the non-benzodiazepine anxiolytics buspirone and lesopitron on the expression of c-Fos immunoreactivity in the rat forebrain. Haloperidol and buspirone administration resulted in a signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c8a5c49a1471a45289c80a4e600665
https://doi.org/10.1016/s0006-8993(96)00975-4
https://doi.org/10.1016/s0006-8993(96)00975-4
Autor:
Jameel Hourani, John J. Sramek, Neal R. Cutler, C.M. Jensen, Fresquet A, Stanford S. Jhee, Martinez L, Bolles K, A.T. Carrington, G. Marion-Landais
Publikováno v:
Journal of Clinical Psychopharmacology. 16:454-458
Lesopitron, a 5-hydroxytryptamine 1A agonist, is a new potential anxiolytic of the azapirone class. It has greater potency in animal models of anxiety than buspirone, gepirone, or ipsapirone, and it lacks the antidopaminergic effects associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8b49f86c237ea2bb20f692b7286b91
https://doi.org/10.1097/00004714-199612000-00009
https://doi.org/10.1097/00004714-199612000-00009
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 15:13-19
A new labelling approach of haptenic drugs with digoxigenin for the development of competitive enzyme immunoassay (EIA) is reported. It consists of the covalent linking of the hapten to the preactivated digoxigenin derivative and revealing the immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb6576b4fa099a67894c619697be975
https://doi.org/10.1016/0731-7085(96)01789-x
https://doi.org/10.1016/0731-7085(96)01789-x
Autor:
Marie-Claire Rettori, B Guardiola-Lemaı̂tre, D. Caroline Blanchard, Robert J. Blanchard, Guy Griebel
Publikováno v:
Pharmacology Biochemistry and Behavior. 54:509-516
This study evaluated the pharmacological and behavioral effects of S 21,357, a drug with high affinity for both 5-HT1A and 5-HT2A receptors. The drug behaved as antagonist at both 5-HT1A autoreceptors and postsynaptic 5-HT1A receptors, as it prevente
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c4a94d6247c28a8c1dfa70eb71a50a
https://doi.org/10.1016/0091-3057(95)02215-5
https://doi.org/10.1016/0091-3057(95)02215-5
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 670:103-110
A totally automated liquid chromatographic assay method based on a Prospekt solid-phase extraction unit was developed for the analysis of lesopitron and its metabolite 5-hydroxylesopitron in human plasma. On-line solid-phase extraction of lesopitron,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909e671775faf2cffbd8b1ebd8eba41d
https://doi.org/10.1016/0378-4347(95)00138-9
https://doi.org/10.1016/0378-4347(95)00138-9
Autor:
Antonio Farré, T. Jolas, Henri Gozlan, A. M. Laporte, Samir Haj-Dahmane, Laurence Lanfumey, Michel Hamon
Publikováno v:
European Journal of Pharmacology. 255:185-196
Previous studies have shown that the 5-HT1A receptor ligand, lesopitron (E-4424, 2-[4-[4-(4-chloro-1-pyrazolyl)butyl]-1-piperazinyl]pyrimidine), exerts potent anxiolytic-like effects in rodents and monkeys (Costall et al., 1992, J. Pharmacol. Exp. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8faf38fa9c5d44b859b52cb6598e67e8
https://doi.org/10.1016/0014-2999(94)90097-3
https://doi.org/10.1016/0014-2999(94)90097-3