Zobrazeno 1 - 10
of 383
pro vyhledávání: '"Lesniak R"'
Autor:
Bush, J, Lesniak, R, Yeh, T, Belle, R, Kramer, H, Tumber, A, Chowdhury, R, Flashman, E, Mecinovic, J, Schofield, C
Publikováno v:
Bush, J T, Leśniak, R K, Yeh, T L, Belle, R, Kramer, H, Tumber, A, Chowdhury, R, Flashman, E, Mecinović, J & Schofield, C J 2019, ' Small-molecules that covalently react with a human prolyl hydroxylase-towards activity modulation and substrate capture ', Chemical Communications, vol. 55, no. 8, pp. 1020-1023 . https://doi.org/10.1039/c8cc07706a
We describe covalently binding modulators of the activity of human prolyl hydroxylase domain 2 (PHD2) and studies towards a strategy for photocapture of PHD2 substrates. Reversible active site binding of electrophile bearing compounds enables susbseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c51852a308e76e7b3e7f5727fcc6d0bd
https://findresearcher.sdu.dk:8443/ws/files/145976068/c8cc07706a.pdf
https://findresearcher.sdu.dk:8443/ws/files/145976068/c8cc07706a.pdf
Autor:
Lesniak, R
The work described in this thesis focused on members of the Fe(II), 2-oxoglutarate dependent oxygenase family that are involved in the biosynthesis of L-carnitine in mammals and in hypoxia sensing. Work on metallo β-lactamases was also carried out.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::2bbbb61962b8a96fef4448ea1f900c1f
https://ora.ox.ac.uk/objects/uuid:2f3306d4-33bf-4b29-a384-ca13a082b5f0
https://ora.ox.ac.uk/objects/uuid:2f3306d4-33bf-4b29-a384-ca13a082b5f0
Autor:
Newman H; School of Life Sciences, University of Warwick, Coventry CV4 7AL, U.K.; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0DE, U.K., Krajnc A; Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, U.K., Bellini D; School of Life Sciences, University of Warwick, Coventry CV4 7AL, U.K., Eyermann CJ; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa., Boyle GA; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa., Paterson NG; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0DE, U.K., McAuley KE; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0DE, U.K., Lesniak R; Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, U.K., Gangar M; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa., von Delft F; Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0DE, U.K.; Structural Genomics Consortium (SGC), University of Oxford, Oxford, U.K.; Department of Biochemistry, University of Johannesburg, Auckland Park 2006, South Africa.; Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, U.K., Brem J; Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, U.K., Chibale K; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa., Schofield CJ; Department of Chemistry and the Ineos Oxford Institute of Antimicrobial Research, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, U.K., Dowson CG; School of Life Sciences, University of Warwick, Coventry CV4 7AL, U.K.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2021 Aug 12; Vol. 64 (15), pp. 11379-11394. Date of Electronic Publication: 2021 Jul 31.
Publikováno v:
Dermatology Nursing. Jul2009, Vol. 21 Issue 4, p211-213. 3p.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Li GB; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk jurgen.brem@chem.ox.ac.uk., Brem J, Lesniak R, Abboud MI, Lohans CT, Clifton IJ, Yang SY, Jiménez-Castellanos JC, Avison MB, Spencer J, McDonough MA, Schofield CJ
Publikováno v:
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2017 May 30; Vol. 53 (43), pp. 5806-5809.
Autor:
Colarusso, Ester1 (AUTHOR) ecolarusso@unisa.it, Chini, Maria Giovanna2 (AUTHOR) mariagiovanna.chini@unimol.it, Bifulco, Giuseppe1 (AUTHOR) bifulco@unisa.it, Lauro, Gianluigi1 (AUTHOR) glauro@unisa.it, Giordano, Assunta3 (AUTHOR) assunta.giordano@cnr.it
Publikováno v:
Pharmaceuticals (14248247). Mar2024, Vol. 17 Issue 3, p392. 31p.
Autor:
Chen P; Department of Chemical Biology, GlaxoSmithKline , Research Triangle Park, 5 Moore Drive, Research Triangle Park, North Carolina 27709-3398, United States., Chaikuad A; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford , Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom., Bamborough P; Computational & Structural Chemistry, Molecular Discovery Research, and ⊥Epinova, Discovery Performance Unit, GlaxoSmithKline R&D , Stevenage, Hertfordshire SG1 2NY, United Kingdom., Bantscheff M; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline , Meyerhofstrasse 1, 69117 Heidelberg, Germany., Bountra C; Nuffield Department of Clinical Medicine, Target Discovery Institute, University of Oxford , NDM Research Building, Roosevelt Drive, Headington, Oxford OX3 7FZ, United Kingdom., Chung CW; Computational & Structural Chemistry, Molecular Discovery Research, and ⊥Epinova, Discovery Performance Unit, GlaxoSmithKline R&D , Stevenage, Hertfordshire SG1 2NY, United Kingdom., Fedorov O; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford , Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom.; Nuffield Department of Clinical Medicine, Target Discovery Institute, University of Oxford , NDM Research Building, Roosevelt Drive, Headington, Oxford OX3 7FZ, United Kingdom., Grandi P; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline , Meyerhofstrasse 1, 69117 Heidelberg, Germany., Jung D; Department of Chemical Biology, GlaxoSmithKline , Research Triangle Park, 5 Moore Drive, Research Triangle Park, North Carolina 27709-3398, United States., Lesniak R; Department of Chemical Biology, GlaxoSmithKline , Research Triangle Park, 5 Moore Drive, Research Triangle Park, North Carolina 27709-3398, United States., Lindon M, Müller S; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford , Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom.; Nuffield Department of Clinical Medicine, Target Discovery Institute, University of Oxford , NDM Research Building, Roosevelt Drive, Headington, Oxford OX3 7FZ, United Kingdom., Philpott M; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford , Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom.; Nuffield Department of Clinical Medicine, Target Discovery Institute, University of Oxford , NDM Research Building, Roosevelt Drive, Headington, Oxford OX3 7FZ, United Kingdom., Prinjha R, Rogers C; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford , Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom.; Nuffield Department of Clinical Medicine, Target Discovery Institute, University of Oxford , NDM Research Building, Roosevelt Drive, Headington, Oxford OX3 7FZ, United Kingdom., Selenski C; Department of Chemical Biology, GlaxoSmithKline , Research Triangle Park, 5 Moore Drive, Research Triangle Park, North Carolina 27709-3398, United States., Tallant C; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford , Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom.; Nuffield Department of Clinical Medicine, Target Discovery Institute, University of Oxford , NDM Research Building, Roosevelt Drive, Headington, Oxford OX3 7FZ, United Kingdom., Werner T; Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline , Meyerhofstrasse 1, 69117 Heidelberg, Germany., Willson TM; Department of Chemical Biology, GlaxoSmithKline , Research Triangle Park, 5 Moore Drive, Research Triangle Park, North Carolina 27709-3398, United States., Knapp S; Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford , Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, United Kingdom.; Nuffield Department of Clinical Medicine, Target Discovery Institute, University of Oxford , NDM Research Building, Roosevelt Drive, Headington, Oxford OX3 7FZ, United Kingdom.; Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University , Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Drewry DH; Department of Chemical Biology, GlaxoSmithKline , Research Triangle Park, 5 Moore Drive, Research Triangle Park, North Carolina 27709-3398, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2016 Feb 25; Vol. 59 (4), pp. 1410-24. Date of Electronic Publication: 2015 Apr 06.
Autor:
Lesniak R (AUTHOR)
Publikováno v:
Dermatology Nursing. Dec2008, Vol. 20 Issue 6, p471-472. 2p.
Autor:
Lesniak R (AUTHOR)
Publikováno v:
Dermatology Nursing. Oct2008, Vol. 20 Issue 5, p403-404. 2p.