Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Leslie Y Beh"'
Publikováno v:
eLife, Vol 11 (2022)
Ciliates are microbial eukaryotes that undergo extensive programmed genome rearrangement, a natural genome editing process that converts long germline chromosomes into smaller gene-rich somatic chromosomes. Three well-studied ciliates include Oxytric
Externí odkaz:
https://doaj.org/article/fb70b360465e48899f4f5691e18e764c
Autor:
Lee Chuen Liew, Boon Min Poh, Omer An, Beatrice Xuan Ho, Christina Ying Yan Lim, Jeremy Kah Sheng Pang, Leslie Y. Beh, Henry He Yang, Boon-Seng Soh
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background Human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) hold great promise for cardiac disease modelling, drug discovery and regenerative medicine. Despite the advancement in various differentiation protocols, the heteroge
Externí odkaz:
https://doaj.org/article/f54f98119d2742b692c09b963cbbc537
Autor:
Michael W. Lu, Leslie Y. Beh, V. Talya Yerlici, Wenwen Fang, Katarzyna Kulej, Benjamin A. Garcia, Laura F. Landweber
Publikováno v:
Microorganisms, Vol 11, Iss 2, p 343 (2023)
Nuclear dimorphism is a fundamental feature of ciliated protozoa, which have separate somatic and germline genomes in two distinct organelles within a single cell. The transcriptionally active somatic genome, contained within the physically larger ma
Externí odkaz:
https://doaj.org/article/7aaf0ba8f0d640829ade41f1ce3dd387
Autor:
Florian T. Hoffmann, Minjoo Kim, Leslie Y. Beh, Jing Wang, Phuc Leo H. Vo, Diego R. Gelsinger, Jerrin Thomas George, Christopher Acree, Jason T. Mohabir, Israel S. Fernández, Samuel H. Sternberg
Publikováno v:
Nature. 609:384-393
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f672a117dfa2faea2b1d891856b74550
https://doi.org/10.1038/s41586-022-05059-4
https://doi.org/10.1038/s41586-022-05059-4
Publikováno v:
Genome Biology and Evolution
Ciliates are microbial eukaryotes with distinct somatic and germline genomes. Postzygotic development involves extensive remodeling of the germline genome to form somatic chromosomes. Ciliates therefore offer a valuable model for studying the archite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408a82b656f51351732995fc11d11aae
http://europepmc.org/articles/PMC7586852
http://europepmc.org/articles/PMC7586852
Autor:
Florian T, Hoffmann, Minjoo, Kim, Leslie Y, Beh, Jing, Wang, Phuc Leo H, Vo, Diego R, Gelsinger, Jerrin Thomas, George, Christopher, Acree, Jason T, Mohabir, Israel S, Fernández, Samuel H, Sternberg
Publikováno v:
Nature. 609(7926)
Bacterial transposons are pervasive mobile genetic elements that use distinct DNA-binding proteins for horizontal transmission. For example, Escherichia coli Tn7 homes to a specific attachment site using TnsD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb696ee4a72299ae445e131296d27120
https://pubmed.ncbi.nlm.nih.gov/36002573
https://pubmed.ncbi.nlm.nih.gov/36002573
Ciliates are microbial eukaryotes with distinct somatic and germline genomes. Post-zygotic development involves extensive remodeling of the germline genome to form somatic chromosomes. Ciliates therefore offer a valuable model for studying the archit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70cc6fcc3340bdf7587af04b3bd307e
https://doi.org/10.1101/2020.05.05.079426
https://doi.org/10.1101/2020.05.05.079426
Autor:
Sanne E. Klompe, Nora Jaber, Leslie Y. Beh, Jason T. Mohabir, Aude Bernheim, Samuel H. Sternberg
Publikováno v:
Mol Cell
Canonical CRISPR-Cas systems utilize RNA-guided nucleases for targeted cleavage of foreign nucleic acids, whereas some nuclease-deficient CRISPR-Cas complexes have been repurposed to direct the insertion of Tn7-like transposons. Here, we established
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9b1a9f848c4738b6a02c6b0b65fb12
https://doi.org/10.1016/j.molcel.2021.12.021
https://doi.org/10.1016/j.molcel.2021.12.021
Autor:
Leslie Y. Beh, Tom W. Muir, Elizabeth Hutton, Laura F. Landweber, Bracht, Kelsi A. Lindblad, Galia T. Debelouchina, Robert Sebra, Robert E. Thompson, Derek M. Clay
SummaryDNA N6-adenine methylation (6mA) has recently been reported in diverse eukaryotes, spanning unicellular organisms to metazoans. Yet the functional significance of 6mA remains elusive due to its low abundance, difficulty of manipulation within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15403892637c4b1145a8cb2310767ce0