Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Leslie Wachter"'
Autor:
Ami Patel, Antonio DiGiandomenico, Ashley E. Keller, Trevor R. F. Smith, Daniel H. Park, Stephanie Ramos, Katherine Schultheis, Sarah T. C. Elliott, Janess Mendoza, Kate E. Broderick, Megan C. Wise, Jian Yan, Jingjing Jiang, Seleeke Flingai, Amir S. Khan, Kar Muthumani, Laurent Humeau, Lily I. Cheng, Leslie Wachter-Rosati, C. Kendall Stover, Niranjan Y. Sardesai, David B. Weiner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
DNA-delivered monoclonal antibodies (DMAbs) can be produced by muscle cells in vivo, potentially allowing prevention or treatment of infectious diseases. Here, the authors show that two DMAbs targeting Pseudomonas aeruginosa proteins confer protectio
Externí odkaz:
https://doaj.org/article/5cc6f71f1078455d97d037b4f8457a6b
Autor:
Sarah T. C. Elliott, Nicole L. Kallewaard, Ebony Benjamin, Leslie Wachter-Rosati, Josephine M. McAuliffe, Ami Patel, Trevor R. F. Smith, Katherine Schultheis, Daniel H. Park, Seleeke Flingai, Megan C. Wise, Janess Mendoza, Stephanie Ramos, Kate E. Broderick, Jian Yan, Laurent M. Humeau, Niranjan Y. Sardesai, Kar Muthumani, Qing Zhu, David B. Weiner
Publikováno v:
npj Vaccines, Vol 2, Iss 1, Pp 1-9 (2017)
Nucleic acid delivery: Instant, wide-ranging protection against influenza A and B A novel innoculation technique involving the injection of antibody-producing plasmid DNA has shown to be effective against influenza in mice. The flu is responsible for
Externí odkaz:
https://doaj.org/article/eacd8d537f1948d3bf6f77c99669bab8
Autor:
Barbara Guarino, Ursula Neu, Philip A. Walker, Patrick J. Collins, Frances J. Palmer-Hill, Josephine M. McAuliffe, Fabrizia Vanzetta, JoAnn Suzich, Anna De Marco, Stephen R. Martin, Roksana W. Ogrodowicz, Leslie Wachter-Rosati, Qing Zhu, Steven J. Gamblin, Gloria Agatic, Chiara Silacci, Andy Q. Yuan, Nicole L. Kallewaard, Debora Pinna, Mathilde Foglierini, Alexander Fruehwirth, Federica Sallusto, John J. Skehel, Matthias K. Vorlaender, Antonio Lanzavecchia, Ebony Benjamin, Davide Corti, Siro Bianchi, Blanca Fernandez-Rodriguez
Publikováno v:
Cell
Cell, 166 (3)
Cell, 166 (3)
Summary Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852,
Autor:
Antonio DiGiandomenico, Karuppiah Muthumani, Ashley E. Keller, Niranjan Y. Sardesai, Leslie Wachter-Rosati, Lily Cheng, Janess M. Mendoza, David B. Weiner, Laurent Humeau, Stephanie Ramos, C. Kendall Stover, Daniel H. Park, Jingjing Jiang, Seleeke Flingai, Amir S. Khan, Kate E. Broderick, Sarah T. C. Elliott, Jian Yan, Ami Patel, Katherine Schultheis, Megan C. Wise, Trevor R.F. Smith
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The impact of broad-spectrum antibiotics on antimicrobial resistance and disruption of the beneficial microbiome compels the urgent investigation of bacteria-specific approaches such as antibody-based strategies. Among these, DNA-delivered monoclonal
Autor:
Qing Zhu, Janess M. Mendoza, Sarah T. C. Elliott, David B. Weiner, Ami Patel, Trevor R.F. Smith, Leslie Wachter-Rosati, Jian Yan, Megan C. Wise, Seleeke Flingai, Nicole L. Kallewaard, Karuppiah Muthumani, Daniel H. Park, Ebony Benjamin, Kate E. Broderick, Josephine M. McAuliffe, Niranjan Y. Sardesai, Laurent Humeau, Stephanie Ramos, Katherine Schultheis
Publikováno v:
npj Vaccines
npj Vaccines, Vol 2, Iss 1, Pp 1-9 (2017)
NPJ Vaccines
npj Vaccines, Vol 2, Iss 1, Pp 1-9 (2017)
NPJ Vaccines
Influenza virus remains a significant public health threat despite innovative vaccines and antiviral drugs. A major limitation to current vaccinations and therapies against influenza virus is pathogenic diversity generated by shift and drift. A simpl
Autor:
Brandon Liang, Chin-Fen Yang, Randall S. MacGill, Michael P. McCarthy, Susan Wilson, Nita K. Patel, Leslie Wachter, Qing Zhu, Lan Su, Genevieve A. Losonsky, JoAnn Suzich, Wei Zhu, Subramaniam Krishnan, Josie M. McAuliffe, Frances J. Palmer-Hill
Publikováno v:
The Journal of Infectious Diseases. 203:674-682
Respiratory syncytial virus (RSV) is a member of the Pneumovirus genus in the Paramyxoviridae family. The RSV genome consists of a negative-sense, nonsegmented, single strand of RNA encoding 10 proteins [1]. RSV is an enveloped virus, and its antigen
Autor:
David A. Kulesh, Leslie Wachter, Valerie A. Buckley-Beason, Randal J. Schoepp, Joseph N. Fair, Jordan B. Jahrling, Jeffrey Garrison, David A. Norwood, Lisa E. Hensley, Adrienne R. Trombley, Augustine Goba
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 82:954-960
Viral hemorrhagic fever is caused by a diverse group of single-stranded, negative-sense or positive-sense RNA viruses belonging to the families Filoviridae (Ebola and Marburg), Arenaviridae (Lassa, Junin, Machupo, Sabia, and Guanarito), and Bunyaviri
Autor:
Michael P. McCarthy, Josephine M. McAuliffe, Nita K. Patel, JoAnn Suzich, Wei Zhu, Qing Zhu, Leslie Wachter
Publikováno v:
The Journal of infectious diseases. 205(4)
Specific mutations in respiratory syncytial virus (RSV) fusion protein can cause palivizumab resistance. We assessed the incidence of sequence polymorphisms and palivizumab resistance in clinical RSV isolates collected from immunoprophylaxis-naive su
Publikováno v:
Croatian medical journal. 44(3)
A quantitative polymerase chain reaction (PCR) assay has been developed for the quantification of genomic DNA extracted from domestic cat samples. The assay, which targets highly repetitive genomic short interspersed nuclear elements (SINE), can be p