Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Leslie W. Deady"'
Autor:
Leslie W. Deady, Nathan J. O'Brien, Elliott D. Cope, Brendan S. Crabb, Belinda M. Abbott, Chamodi K. Gardhi, Greta E. Weiss, Melissa J. Buskes, Rebecca M. Christoff, Robabeh Kalhor, Paul R. Gilson, Boris Prinz, Dene R. Littler, Benjamin J. Richards, Katherine L. Harvey
Publikováno v:
Organic & Biomolecular Chemistry. 14:4617-4639
Central to malaria pathogenesis is the invasion of human red blood cells by Plasmodium falciparum parasites. Following each cycle of intracellular development and replication, parasites activate a cellular program to egress from their current host ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc507a46e38bcf23e43e61926e9a482e
https://doi.org/10.1039/c5ob02517f
https://doi.org/10.1039/c5ob02517f
Publikováno v:
Tetrahedron. 70:4947-4956
An efficient and scalable route for a series of novel substituted 2-anilino-7 H -pyrrolopyrimidine compounds as potential inhibitors of PDK1, an important regulator of the PI3K/Akt pathway that is dysregulated in many cancers, was developed and is de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98a35c817afa4dbedcec505876444b69
https://doi.org/10.1016/j.tet.2014.05.033
https://doi.org/10.1016/j.tet.2014.05.033
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:3879-3886
PDK1, a biological target that has attracted a large amount of attention recently, is responsible for the positive regulation of the PI3K/Akt pathway that is often activated in a large number of human cancers. A series of second-generation 2-anilino-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6379587c8e5ffc020a0720ef6cdfaa31
https://doi.org/10.1016/j.bmc.2014.06.018
https://doi.org/10.1016/j.bmc.2014.06.018
Autor:
Nathan J. O'Brien, Ian G. Jennings, Jelena Medan, Syazwani Itri Amran, Benjamin Cleary, Philip E. Thompson, Leslie W. Deady, Belinda M. Abbott
Publikováno v:
ChemMedChem. 8:914-918
Prodrugs for PI3K: A series of substituted analogues of the phosphatidylinositol 3 kinase (PI3K) inhibitor LY294002 were prepared and found to potently inhibit the isolated enzyme but not MCF7 cell proliferation. Two tetrazolyl-substituted analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a41a97d565cce9db24298abda0ece7
https://doi.org/10.1002/cmdc.201200583
https://doi.org/10.1002/cmdc.201200583
Publikováno v:
ChemInform. 45
Title compounds (V) are synthesized via sequential Suzuki coupling of dichloro-pyrrolopyrimidine (I) with boronate (II) followed by Buchwald—Hartwig cross-coupling with various customized anilines (IV).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e6859124f4ca6960109215fde24651a
https://doi.org/10.1002/chin.201451179
https://doi.org/10.1002/chin.201451179
Autor:
Samantha Deed, Leann Tilley, Emma Fox, Martha Kalkanidis, Leslie W. Deady, Patrick G. Bray, Mathirut Mungthin
Publikováno v:
Biochemical Pharmacology. 70:1158-1166
In recent years, resistance to the antimalarial drug, chloroquine, has become widespread. It is, therefore, imperative to find compounds that could replace chloroquine or work synergistically with this drug to overcome chloroquine resistance. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0dfcd1d05b2248ea9985e0cb9f4c9af
https://doi.org/10.1016/j.bcp.2005.07.021
https://doi.org/10.1016/j.bcp.2005.07.021
Autor:
Clare L. Smith, Shangjin Yang, Bruce C. Baguley, Debra Greenhalgh, Leslie W. Deady, Xianyong Bu, Junjie Chen, William A. Denny
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:3657-3665
7-Oxo-7H-naphtho[1,2,3-de]quinoline-11-carboxamides and analogues were prepared and evaluated for in vitro and in vivo antitumor activity. Chromophore variations included 'deaza' (7-oxo-7H-benz[de]anthracene) and 'diaza' (7-oxo-7H-benzo[e]perimidine)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310bd190eb27df8c9317d418105b0775
https://doi.org/10.1016/j.bmc.2005.03.033
https://doi.org/10.1016/j.bmc.2005.03.033
Autor:
Shane M. Devine, Leslie W. Deady
Publikováno v:
Journal of Heterocyclic Chemistry. 41:549-555
1-Acetylirruno-3-methyl-1H-isochromene-4-carbonitrile, 1, reacts with glycine ethyl ester under basic conditions to give an imidazo[2,1-a]isoquinoline derivative, while reaction with hydrazine hydrate in 1,4-dioxane, with further chemistry, provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f48b02b446f367a9ff9c39932f256b
https://doi.org/10.1002/jhet.5570410411
https://doi.org/10.1002/jhet.5570410411
Publikováno v:
Synthetic Communications. 33:4269-4277
A water-soluble oxonol dye containing a reactive hydroxysuccinimidyl ester suitable for reaction with biomolecules has been prepared. This fluorescent compound has 631 nm, eabs 147,000 M−1 cm−1, 659 nm, and quantum yield 0.30.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ed260adc7bf9db107a79b66ea23f5a
https://doi.org/10.1081/scc-120026856
https://doi.org/10.1081/scc-120026856
Autor:
Leslie W. Deady, Michael J. Rogers, Frederick Cohen, Septima B. Hong, Aaron T. Fafarman, Stanley B. Prusiner, Barnaby C. H. May
Publikováno v:
Proceedings of the National Academy of Sciences. 100:3416-3421
Prion diseases are characterized by an accumulation of PrP Sc , a misfolded isoform of the normal cellular prion protein, PrP C . We previously reported the bioactivity of acridine-based compounds against PrP Sc replication in scrapie-infected neurob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558c00f92a2f36cede0c9bc9d2c5e0a4
https://doi.org/10.1073/pnas.2627988100
https://doi.org/10.1073/pnas.2627988100