Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Leslie V. Parise"'
Autor:
Stephen P. Holly, Nidhi Gera, Putianqi Wang, Alexander Wilson, Ziqiang Guan, Ling Lin, Brian Cooley, Hammodah R. Alfar, Ruchi G. Patil, Raymond Piatt, Tina M. Leisner, Wolfgang Bergmeier, Rinku Majumder, Leslie V. Parise
Publikováno v:
Blood Advances, Vol 3, Iss 22, Pp 3818-3828 (2019)
Abstract: We previously reported the discovery of a novel lipid deacetylase in platelets, arylacetamide deacetylase-like 1 (AADACL1/NCEH1), and that its inhibition impairs agonist-induced platelet aggregation, Rap1 GTP loading, protein kinase C (PKC)
Externí odkaz:
https://doaj.org/article/cfd11219f3594d06852884f8acda0943
Autor:
Alexander H. Chung, Tina M. Leisner, Gabrielle J. Dardis, Marissa M. Bivins, Alana L. Keller, Leslie V. Parise
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background Patients diagnosed with triple negative breast cancer (TNBC) have limited treatment options and often suffer from resistance and toxicity due to chemotherapy. We previously found that depleting calcium and integrin-binding protein
Externí odkaz:
https://doaj.org/article/64814e89ae9f4883b03e0fd9d402ab0e
Autor:
Elizabeth C. Wayne, Christian Long, Matthew J. Haney, Elena V. Batrakova, Tina M. Leisner, Leslie V. Parise, Alexander V. Kabanov
Publikováno v:
Advanced Science, Vol 6, Iss 21, Pp n/a-n/a (2019)
Abstract Delivery of nucleic acids into solid tumor environments remains a pressing challenge. This study examines the ability of macrophages to horizontally transfer small interfering RNA (siRNA) lipoplexes to cancer cells. Macrophages are a natural
Externí odkaz:
https://doaj.org/article/588c1ca743bb4fdf881e4c3a28d78148
Autor:
Ling Xie, Cui Liu, Li Wang, Harsha P. Gunawardena, Yanbao Yu, Ruyun Du, Debra J. Taxman, Penggao Dai, Zhen Yan, Jing Yu, Stephen P. Holly, Leslie V. Parise, Yisong Y. Wan, Jenny P. Ting, Xian Chen
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 678-688 (2013)
MyD88, the intracellular adaptor of most TLRs, mediates either proinflammatory or immunosuppressive signaling that contributes to chronic inflammation-associated diseases. Although gene-specific chromatin modifications regulate inflammation, the role
Externí odkaz:
https://doaj.org/article/3c25ab3ac97b41b2bfa7c0f33761c676
Autor:
Kenneth I. Ataga, Charity G. Moore, Cheryl A. Hillery, Susan Jones, Herbert C. Whinna, Dell Strayhorn, Cathy Sohier, Alan Hinderliter, Leslie V. Parise, Eugene P. Orringer
Publikováno v:
Haematologica, Vol 93, Iss 1 (2008)
Background Pulmonary hypertension (PHT) is common in sickle cell disease (SCD). The purpose of this study was to determine whether markers of coagulation activation and inflammation are associated with PHT in SCD.Design and Methods This cross-section
Externí odkaz:
https://doaj.org/article/157c01888509446597939806e0b47188
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 43:385-387
Autor:
Yuki Goto, Ana C. Puhl, Kenneth H. Pearce, Victoria A Haberman, Xian Chen, Dmitri Kireev, Emerald Hillary Feng, Steven R Fleming, Albert A. Bowers, Hiroaki Suga, Leslie V. Parise, Ling Xie, Tina M. Leisner
Publikováno v:
ACS Med Chem Lett
[Image: see text] Calcium and integrin binding protein 1 (CIB1) is a small, intracellular protein recently implicated in survival and proliferation of triple-negative breast cancer (TNBC). Considering its interactions with PAK1 and downstream signali
Autor:
Putianqi Wang, Ruchi G. Patil, Ziqiang Guan, Ling Lin, Wolfgang Bergmeier, Brian C. Cooley, Leslie V. Parise, Nidhi Gera, Raymond Piatt, Stephen P. Holly, Tina M. Leisner, Rinku Majumder, Hammodah R. Alfar, Alexander Wilson
Publikováno v:
Blood Advances. 3:3818-3828
We previously reported the discovery of a novel lipid deacetylase in platelets, arylacetamide deacetylase-like 1 (AADACL1/NCEH1), and that its inhibition impairs agonist-induced platelet aggregation, Rap1 GTP loading, protein kinase C (PKC) activatio
Autor:
Gabrielle J. Dardis, Alana L. Keller, Alexander H. Chung, Leslie V. Parise, Marissa M. Bivins, Tina M. Leisner
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-15 (2019)
Cancer Cell International
Cancer Cell International
Background Patients diagnosed with triple negative breast cancer (TNBC) have limited treatment options and often suffer from resistance and toxicity due to chemotherapy. We previously found that depleting calcium and integrin-binding protein 1 (CIB1)
Autor:
Laila Elsherif, Mehmet Ozler, Mohamed A Zayed, Jessica H Shen, Jonathan Chernoff, James E Faber, Leslie V Parise
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112239 (2014)
PAKs are serine/threonine kinases that regulate cytoskeletal dynamics and cell migration. PAK1 is activated by binding to the small EF hand protein, CIB1, or to the Rho GTPases Rac1 or Cdc42. The role of PAK1 in angiogenesis was established based onl
Externí odkaz:
https://doaj.org/article/8976177641be43ec973644d49e4f9d19