Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Leslie Todd"'
Autor:
Frederick W.K. Tam, James Tumlin, Jonathan Barratt, Brad H. Rovin, Ian S.D. Roberts, Candice Roufosse, H. Terence Cook, Gurjeet Bhangal, Alison L. Brown, Martin Busch, Fayaz Dudhiya, Anne-Marie Duliege, Donald J. Fraser, Daniel P. Gale, Chiu-Ching Huang, Ping-Chin Lai, Meng Lee, Esteban S. Masuda, Stephen P. McAdoo, Alexander R. Rosenkranz, Claudia Sommerer, Gere Sunder-Plassmann, Cheuk-Chun Szeto, Sydney C.W. Tang, Don E. Williamson, Lisa Willcocks, Volker Vielhauer, Min Jeong Kim, Leslie Todd, Hany Zayed, Sandra Tong-Starksen, Richard Lafayette
Publikováno v:
Kidney International Reports, Vol 8, Iss 12, Pp 2546-2556 (2023)
Introduction: We reported increased spleen tyrosine kinase (SYK) expression in kidney biopsies of patients with IgA nephropathy (IgAN) and that inhibition of SYK reduces inflammatory cytokines production from IgA stimulated mesangial cells. Methods:
Externí odkaz:
https://doaj.org/article/66982ca5bf66483cb14ee295eaf07526
Autor:
Zebin Xiao, Leslie Todd, Li Huang, Estela Noguera-Ortega, Zhen Lu, Lili Huang, Meghan Kopp, Yue Li, Nimisha Pattada, Wenqun Zhong, Wei Guo, John Scholler, Maria Liousia, Charles-Antoine Assenmacher, Carl H. June, Steven M. Albelda, Ellen Puré
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract The desmoplastic stroma in solid tumors presents a formidable challenge to immunotherapies that rely on endogenous or adoptively transferred T cells, however, the mechanisms are poorly understood. To define mechanisms involved, here we treat
Externí odkaz:
https://doaj.org/article/8293ae22274440439fe76629503609b5
Publikováno v:
HemaSphere, Vol 7, p e14426d1 (2023)
Externí odkaz:
https://doaj.org/article/22c84fd0cbb84c468f2a2fd015e33b38
Autor:
Mark A. Sellmyer, Ellen Puré, Steven M. Albelda, Carl H. June, Michael D. Farwell, Kimberly J. Edwards, Kexiang Xu, Katheryn Lohith, Maria Liousia, Decheng Song, John Scholler, Leslie Todd, Zebin Xiao, Estela Noguera-Ortega, Iris K. Lee
Supplementary Data from Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653c5550bfef8e854c6adbed18086a90
https://doi.org/10.1158/1078-0432.22488903
https://doi.org/10.1158/1078-0432.22488903
Autor:
Mark A. Sellmyer, Ellen Puré, Steven M. Albelda, Carl H. June, Michael D. Farwell, Kimberly J. Edwards, Kexiang Xu, Katheryn Lohith, Maria Liousia, Decheng Song, John Scholler, Leslie Todd, Zebin Xiao, Estela Noguera-Ortega, Iris K. Lee
Purpose:Despite the success of chimeric antigen receptor (CAR) T-cell therapy against hematologic malignancies, successful targeting of solid tumors with CAR T cells has been limited by a lack of durable responses and reports of toxicities. Our under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63908ed243288c17d971b25c5c1ecafe
https://doi.org/10.1158/1078-0432.c.6532830.v1
https://doi.org/10.1158/1078-0432.c.6532830.v1
Autor:
Mark A. Sellmyer, Ellen Puré, Steven M. Albelda, Carl H. June, Michael D. Farwell, Kimberly J. Edwards, Kexiang Xu, Katheryn Lohith, Maria Liousia, Decheng Song, John Scholler, Leslie Todd, Zebin Xiao, Estela Noguera-Ortega, Iris K. Lee
Supplementary Figure from Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43717d861d181e3b795e7953d02d75a1
https://doi.org/10.1158/1078-0432.22488897
https://doi.org/10.1158/1078-0432.22488897
Autor:
Iris K. Lee, Estela Noguera-Ortega, Zebin Xiao, Leslie Todd, John Scholler, Decheng Song, Maria Liousia, Katheryn Lohith, Kexiang Xu, Kimberly J. Edwards, Michael D. Farwell, Carl H. June, Steven M. Albelda, Ellen Puré, Mark A. Sellmyer
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 28(24)
Purpose: Despite the success of chimeric antigen receptor (CAR) T-cell therapy against hematologic malignancies, successful targeting of solid tumors with CAR T cells has been limited by a lack of durable responses and reports of toxicities. Our unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde2b4351f8a37eb490ec13f73881dda
https://pubmed.ncbi.nlm.nih.gov/36250927
https://pubmed.ncbi.nlm.nih.gov/36250927
Autor:
James B. Bussel, Quentin A. Hill, Michelle Sholzberg, Nichola Cooper, Michael D. Tarantino, Sandra Tong, Leslie Todd, Ralph V. Boccia, Michael Boxer, Waleed Ghanima
Publikováno v:
British Journal of Haematology
Fostamatinib demonstrated efficacy in phase 3 trials of adults with immune thrombocytopenia (ITP). Post hoc analysis compared patients who received fostamatinib as second‐line therapy (after steroids ± immunoglobulins) versus third‐or‐later‐
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9386d56a8017c6d25bb456b3db7392d4
http://europepmc.org/articles/PMC7540289
http://europepmc.org/articles/PMC7540289
Autor:
Jun Gui, Angelica Ortiz, Cindy Sander, Leslie Todd, J. Alan Diehl, Sandra Ryeom, Dmitry I. Gabrilovich, Christina Cho, John M. Kirkwood, Kevin Alicea-Torres, Jinyang Li, Andrew Wakeham, Kanstantsin V. Katlinski, Bryan E. Snow, Ben Z. Stanger, Daniel P. Beiting, Hongru Zhang, Farima Zahedi, Serge Y. Fuchs, Tak W. Mak, Ellen Puré, Constantinos Koumenis
Publikováno v:
Nature Cancer. 1:603-619
Primary tumor-derived factors act upon normal cells to generate a pre-metastatic niche, which promotes colonization of target organs by disseminated malignant cells. Here we report that tumor-derived factor-induced activation of the p38α kinase in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5cb185b1f3b5acff662a49155baaff
https://doi.org/10.1038/s43018-020-0064-0
https://doi.org/10.1038/s43018-020-0064-0
Autor:
Leslie Todd, Richard K. Assoian, Ellen Puré, Priya Govindaraju, John E. Chojnowski, James Monslow
Publikováno v:
Am J Pathol
Fibroblast activation protein (FAP) has been established as an inducible and mesenchymal cell-specific mediator of disease progression in cancer and fibrosis. Atherosclerosis is a fibroinflammatory disease, and FAP was previously reported to be up-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b77c9cd1db0a05db31d8651dce8ddeb
https://doi.org/10.1016/j.ajpath.2020.01.004
https://doi.org/10.1016/j.ajpath.2020.01.004