Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Leslie Summers-Deluca"'
Autor:
Amanda L. Mayo, Vera Fung, Sander L. Hitzig, Sarah Gould, Stephanie Posa, Leslie Summers deLuca, Ahmed Kayssi
Publikováno v:
Disability and Rehabilitation. :1-10
Following major lower extremity amputation (LEA), patients experience significant emotional distress and are at risk for anxiety and depression. There is a lack of mental health supports for this population, and internet-based cognitive behavioural t
Publikováno v:
Seminars in vascular surgery. 35(4)
Qualitative research aims to understand and describe subjective experiences and perceptions. Qualitative and mixed-methods research, in which quantitative and qualitative research methods are combined, is playing an increasingly bigger role in vascul
Publikováno v:
Journal of Vascular Surgery. 76:e118-e119
Autor:
Hanane Touil, Brendan Heiden, Samuel K. Ludwin, Paul O'Connor, Jennifer L. Gommerman, Valera Castanov, Deepali Malhotra, Robert Kay, Shannon J. Turley, Alexandre Prat, Natalia Pikor, Amit Bar-Or, Lesley A. Ward, Joy Qu, Susan J. Armstrong, Georgina Galicia, Jillian L. Astarita, Valeria Ramaglia, Louis Boon, Leslie Summers-Deluca, Claudia X. Dominguez
Publikováno v:
Immunity. 43:1160-1173
SummaryTertiary lymphoid tissues (TLTs) have been observed in the meninges of multiple sclerosis (MS) patients, but the stromal cells and molecular signals that support TLTs remain unclear. Here, we show that T helper 17 (Th17) cells induced robust T
Autor:
Olga L. Rojas, Bryant Boulianne, Dennis K. P. Ng, Lesley A. Ward, Barbara C. Mindt, Claudia U. Duerr, Leslie Summers deLuca, Jennifer L. Gommerman, Jörg H. Fritz, Doug McCarthy, Mingxi Dennis Yu, Maude Paradis, Dana J. Philpott, James B. Waldron
Publikováno v:
The Journal of Immunology. 192:2787-2799
Innate immune responses provoke the accumulation of leukocytes at sites of inflammation. In addition to monocytes and granulocytes, B cells also participate in antimicrobial innate immune responses; however, the mechanisms for accumulation of B cells
Publikováno v:
Nature Reviews Immunology. 12:339-351
Members of the tumour necrosis factor (TNF) superfamily have been implicated in a wide range of biological functions, and their expression by cells of the immune system makes them appealing targets for immunomodulation. One common theme for TNF super
Autor:
Håkan Hall, Nancy Berg-Brown, Sara R. Hamilton, Jennifer L. Gommerman, Leslie Summers deLuca, Pamela S. Ohashi, Kiichi Murakami, Alisha R. Elford, Dilan Dissanayake
Publikováno v:
Nature Medicine. 17:1663-1667
Mature dendritic cells (DCs) are crucial for the induction of adaptive immune responses and perturbed DC homeostasis can result in autoimmune disease. Either uncontrolled expansion or enhanced survival of DCs can result in a variety of autoimmune dis
Publikováno v:
Immunological Reviews. 244:85-98
Generating an immune response tailored to destroy an infecting organism while limiting bystander damage involves guiding T-cell activation using a variety of cues taken from the immunogen (antigen type, dose, and persistence, accompanying danger sign
Publikováno v:
Cellular Immunology. 241:85-94
BAFF is a peripheral B cell survival factor and can mediate antibody (Ab) class switching. Over-expression of BAFF in mice results in B cell hyperplasia, elevated serum immunoglobulin (Ig), spontaneous germinal centre (GC) reactions and mild glomerul
Publikováno v:
Blood. 102:237-245
The nuclear receptor ligand all-trans retinoic acid (ATRA) causes dramatic terminal differentiation of acute promyelocytic leukemia (APL) cells in vitro and in patients, but it is less active in other malignancies. However, downstream mediators of th