Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Leslie Shaw"'
Autor:
Nicolai Franzmeier, M. Suárez-Calvet, Lukas Frontzkowski, Annah Moore, Timothy J. Hohman, Estrella Morenas-Rodriguez, Brigitte Nuscher, Leslie Shaw, John Q. Trojanowski, Martin Dichgans, Gernot Kleinberger, Christian Haass, Michael Ewers, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-10 (2020)
Abstract Background The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). TREM2 (i.e. Triggering receptor expressed on myeloid cells 2) is a microglial transmembrane protein brain t
Externí odkaz:
https://doaj.org/article/e39dd285d82e4f3297682ed1c4da700a
Autor:
Michael Ewers, Gloria Biechele, Marc Suárez‐Calvet, Christian Sacher, Tanja Blume, Estrella Morenas‐Rodriguez, Yuetiva Deming, Laura Piccio, Carlos Cruchaga, Gernot Kleinberger, Leslie Shaw, John Q Trojanowski, Jochen Herms, Martin Dichgans, the Alzheimer's Disease Neuroimaging Initiative (ADNI), Matthias Brendel, Christian Haass, Nicolai Franzmeier
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 9, Pp n/a-n/a (2020)
Abstract Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's disease (AD). Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a biomarker of microglia activation, and microglia PET are increased i
Externí odkaz:
https://doaj.org/article/9500415c117547ba868021c5c4d1ca2c
Autor:
Anja Soldan, Abhay Moghekar, Keenan A. Walker, Corinne Pettigrew, Xirui Hou, Hanzhang Lu, Michael I. Miller, Alfonso Alfini, Marilyn Albert, Desheng Xu, Mei-Fang Xiao, Paul Worley, The BIOCARD Research Team, John Csernansky, David Holtzman, David Knopman, Walter Kukull, Kevin Grimm, John Hsiao, Laurie Ryan, Constantine Lyketsos, Carlos Pardo, Gerard Schellenberg, Leslie Shaw, Madhav Thambisetty, John Trojanowski
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Intrinsic functional connectivity of large-scale brain networks has been shown to change with aging and Alzheimer’s disease (AD). These alterations are thought to reflect changes in synaptic function, but the underlying biological mechanisms are po
Externí odkaz:
https://doaj.org/article/3d43d45952624d7faa843d0f79b3448b
Autor:
Liana G. Apostolova, Kristy S. Hwang, Omid Kohannim, David Avila, David Elashoff, Clifford R. Jack, Jr., Leslie Shaw, John Q. Trojanowski, Michael W. Weiner, Paul M. Thompson
Publikováno v:
NeuroImage: Clinical, Vol 4, Iss C, Pp 461-472 (2014)
Biomarkers are the only feasible way to detect and monitor presymptomatic Alzheimer's disease (AD). No single biomarker can predict future cognitive decline with an acceptable level of accuracy. In addition to designing powerful multimodal diagnostic
Externí odkaz:
https://doaj.org/article/de8308d678e340a88b432ada4cd2563a
Autor:
Xiao Da, Jon B. Toledo, Jarcy Zee, David A. Wolk, Sharon X. Xie, Yangming Ou, Amanda Shacklett, Paraskevi Parmpi, Leslie Shaw, John Q. Trojanowski, Christos Davatzikos
Publikováno v:
NeuroImage: Clinical, Vol 4, Iss C, Pp 164-173 (2014)
This study evaluates the individual, as well as relative and joint value of indices obtained from magnetic resonance imaging (MRI) patterns of brain atrophy (quantified by the SPARE-AD index), cerebrospinal fluid (CSF) biomarkers, APOE genotype, and
Externí odkaz:
https://doaj.org/article/a6973439753c48f89c694602da334972
Publikováno v:
American Journal on Intellectual and Developmental Disabilities. 128:66-81
Many U.S. states use the Supports Intensity Scale—Adult Version (SIS-A; Thompson et al., 2015) to inform the distribution of public funds for long-term services and supports. Throughout the COVID-19 pandemic, many states began administering the SIS
Autor:
Jeffrey N. Browndyke, Mary C. Wright, Rosa Yang, Ayesha Syed, John Park, Ashley Hall, Katherine Martucci, Michael J. Devinney, Leslie Shaw, Teresa Waligorska, Eugene W. Moretti, Heather E. Whitson, Harvey J. Cohen, Joseph P. Mathew, Miles Berger
Publikováno v:
Br J Anaesth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488a847b165735af61e9ab145e2286b9
https://europepmc.org/articles/PMC10170390/
https://europepmc.org/articles/PMC10170390/
Autor:
Lucy Mkandawire-Valhmu, Julia Snethen, Jeneile Luebke, Oluwatoyin Olukotun, Alexa A. Lopez, Leslie Shaw, Aisha Kendrick, Maria del Carmen Graf, Eva Silvestre, Ashley Ruiz
Publikováno v:
Advances in Nursing Science. 45:38-52
The purpose of this theoretical article is to analyze the utility of postcolonial, Black, and Chicana feminist frameworks to inform nursing research and practice specific to mental health needs of Latina women migrant farmworkers. Twentieth-century W
Autor:
Priyanka, Baloni, Matthias, Arnold, Luna, Buitrago, Kwangsik, Nho, Herman, Moreno, Kevin, Huynh, Barbara, Brauner, Gregory, Louie, Alexandra, Kueider-Paisley, Karsten, Suhre, Andrew J, Saykin, Kim, Ekroos, Peter J, Meikle, Leroy, Hood, Nathan D, Price, P Murali, Doraiswamy, Cory C, Funk, A Iván, Hernández, Gabi, Kastenmüller, Rebecca, Baillie, Xianlin, Han, Leslie, Shaw
Publikováno v:
Communications biology. 5(1)
Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer’s disease. Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that are associated wi
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