Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Leslie S. Jimenez"'
Autor:
Ahalya Ramanathan, Leslie S. Jimenez
Publikováno v:
Synthesis. 2010:217-220
Bromo and chloro substituents serve as excellent blocking groups on aromatic rings. When a halo substituent is para to an ortho,para-directing group, the ortho positions can be easily functionalized, and the halo group can be subsequently removed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d90ca1166606a2eafaaca510bd638fc
https://doi.org/10.1055/s-0029-1217112
https://doi.org/10.1055/s-0029-1217112
Autor:
Leslie S. Jimenez, Philip G. Williams, Takeshi Yamamoto, Jianjie Ma, Noriaki Ikemoto, Hiromi Morimoto, Kalanethee Paul-Pletzer, Jerome Parness
Publikováno v:
Biochemical Journal. 387:905-909
Dantrolene is an inhibitor of intracellular Ca2+ release from skeletal muscle SR (sarcoplasmic reticulum). Direct photoaffinity labelling experiments using [3H]azidodantrolene and synthetic domain peptides have demonstrated that this drug targets ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f885a409f8d1ffb0a84cf8fe982acc0
https://doi.org/10.1042/bj20041336
https://doi.org/10.1042/bj20041336
Synthesis of 1 H -2,3-dihydropyrrolizine derivatives as precursors of bifunctional alkylating agents
Autor:
Shanthi Rajaraman, Leslie S. Jimenez
Publikováno v:
Tetrahedron. 58:10407-10412
Two 1H-2,3-dihydropyrrolizine derivatives bearing a nitro group at the 6 position have been synthesized and an improved method for nitrating pyrroles using potassium nitrate in trifluoroacetic acid was developed. An efficient, two-step synthesis of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56e64991ebca06d3186770b132706db1
https://doi.org/10.1016/s0040-4020(02)01419-9
https://doi.org/10.1016/s0040-4020(02)01419-9
Autor:
Kyung-hee Kim, Leslie S. Jimenez
Publikováno v:
Tetrahedron: Asymmetry. 12:999-1005
A chiral, non-racemic vinylsulfonium salt 6 was prepared from camphorquinone in seven steps and reacted with indole-2-carboxaldehyde to give a tricyclic azido alcohol 2 in a 35% yield and 43% e.e. and a 40% recovery of the chiral sulfide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f00aa36ccc35c7a45b65d1d7da395862
https://doi.org/10.1016/s0957-4166(01)00170-7
https://doi.org/10.1016/s0957-4166(01)00170-7
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 176:29-47
The preparation of the chiral uinylsulfonium salts 4, 5, and 6 is described. Their use in an annulation with 2-indolecarboxaldehyde and sodium azide proceeds to form the azido alcohol 2 with low asymmetic induction. These results represent an initial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da3623cbf206ef15ffe500f6f0ec3623
https://doi.org/10.1080/10426500108055100
https://doi.org/10.1080/10426500108055100
Autor:
Jerome Parness, Kalanethee Paul-Pletzer, Leslie S. Jimenez, Hiromi Morimoto, Sanjay S. Palnitkar
Publikováno v:
Biochemistry. 40:531-542
Dantrolene is a skeletal muscle relaxant which acts by inhibiting intracellular Ca(2+) release from sarcoplasmic reticulum (SR). It is used primarily in the treatment of malignant hyperthermia (MH), a pharmacogenetic sensitivity to volatile anestheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9bc9f5e7b747c9025199470b7dd6d0
https://doi.org/10.1021/bi001502s
https://doi.org/10.1021/bi001502s
Publikováno v:
Synthetic Communications. 30:351-366
The tetracyclic FR900482 ring skeleton has been synthesized from the 2,3-dihydro-1H-pyrrolo[1,2-a]indole derivative 5. Treatment of 5 with osmium tetraoxide, hydrogen sulfide, magnesium monoperoxyphthalic acid (MMPP), and triphenylphosphine resulted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::649987aa3ded55a98afc739a8fbfeef2
https://doi.org/10.1080/00397910008087328
https://doi.org/10.1080/00397910008087328
Publikováno v:
Tetrahedron. 55:10659-10672
Various dialkyl- and diarylvinylsulfonium salts react with indole-2-carboxaldehydes in the presence of sodium hydride and sodium azide to form tricyclic azido alcohols analogous to 2 . With pyrrole-2-carboxaldehyde, [2,3] sigmatropic and other rearra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18187df045ec39cfe5eb22bcb89e59d9
https://doi.org/10.1016/s0040-4020(99)00605-5
https://doi.org/10.1016/s0040-4020(99)00605-5
Autor:
Weitong Dong, Leslie S. Jimenez
Publikováno v:
The Journal of Organic Chemistry. 64:2520-2523
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfeda7f78ac1039fce7a3fb6ee817bec
https://doi.org/10.1021/jo981143v
https://doi.org/10.1021/jo981143v
Autor:
Leslie S. Jimenez, Zheng Wang
Publikováno v:
Tetrahedron Letters. 37:6049-6052
A synthesis of (±)-Mitomycin K has been achieved in thirteen steps from commerically available 2,5-dimethylanisole in a 1.36% overall yield. One of the key steps is the oxidation of the C9-9a double bond of 1 by (hexamethylphosphoramido)oxodiperoxom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::073222744218e9cb811dd85ce87a59ba
https://doi.org/10.1016/0040-4039(96)01312-3
https://doi.org/10.1016/0040-4039(96)01312-3