Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Leslie S. Casey"'
Autor:
Jonathan French, Alan C. Fisher, Brent J. Yamamoto, Natalya V. Serbina, Nestor Gonzales, Edward O'Connor, Lisa N. Henning, Annette M. Shadiack, Daniel C. Sanford, Sarah Carpenter, Gregory V. Stark, John Mondick, Leslie S. Casey
Publikováno v:
Antimicrobial Agents and Chemotherapy
Inhalational anthrax has high mortality even with antibiotic treatment, and antitoxins are now recommended as an adjunct to standard antimicrobial regimens. The efficacy of obiltoxaximab, a monoclonal antibody against anthrax protective antigen (PA),
Autor:
Daniel C. Sanford, Sarah Carpenter, Lisa N. Henning, Natalya V. Serbina, Nestor Gonzales, Edward O'Connor, Leslie S. Casey, Annette M. Shadiack, Brent J. Yamamoto
Publikováno v:
Antimicrobial Agents and Chemotherapy
The Centers for Disease Control and Prevention recommend adjunctive antitoxins when systemic anthrax is suspected. Obiltoxaximab, a monoclonal antibody against protective antigen (PA), is approved for treatment of inhalational anthrax in combination
Autor:
Susan K. Hollingshead, Neil L. Sparks, Catherine R. Doil, Richard S. Dondero, W. Michael Foster, David E. Briles, Herman F. Staats, Sheena H. Wang, Anthony J. Hickey, Leslie S. Casey, Kathleen A. Ashcraft, William M. Gwinn, Tom G. Tlusty, Shaun M. Kirwan
Publikováno v:
Vaccine. 28:6901-6914
IL-1α and IL-1β were evaluated for their ability to provide adjuvant activity for the induction of serum antibody responses when nasally-administered with protein antigens in mice and rabbits. In mice, intranasal (i.n.) immunization with pneumococc
Autor:
Giovanni D'Alia, Michelle Clagett, Nehal Mohamed, Linda L. Nardone, Michael C. Babin, Steven M. Pincus, Juan Li, Leslie S. Casey, George L. Spitalny, Steven J.M. Jones
Publikováno v:
Infection and Immunity. 73:795-802
We have developed a therapeutic for the treatment of anthrax using an affinity-enhanced monoclonal antibody (ETI-204) to protective antigen (PA), which is the central cell-binding component of the anthrax exotoxins. ETI-204 administered preexposure b
Autor:
Claudia S. Ferreira, Nehal Mohamed, Leslie S. Casey, Arthur M. Friedlander, George L. Spitalny, Stephen F. Little, Juan Li
Publikováno v:
Infection and Immunity. 72:3276-3283
We investigated the ability of using monoclonal antibodies (MAbs) against anthrax protective antigen (PA), an anthrax exotoxin component, to modulate exotoxin cytotoxic activity on target macrophage cell lines. Anthrax PA plays a critical role in the
Autor:
Josaih Adaelu, Rose Ebelle, Nadya Lukacher, Steven E. Pincus, Xun Chen, James P. Porter, Roger Zabinski, Linda L. Nardone, Lisa Duncan, Wu Peng, Muctarr Sesay, George L. Spitalny, Juan Li, Nehal Mohamed, Leslie S. Casey
Publikováno v:
Clinical Immunology. 105:141-154
Autoantibodies that react with double-stranded DNA (dsDNA) are a hallmark for diagnosis of systemic lupus erythematosus (SLE) and are also considered the pathogenic subset that is most associated with lupus nephritis. As an agent to remove the pathog
Publikováno v:
Current opinion in molecular therapeutics. 7(2)
Heteropolymer (HP) technology is a novel cassette technology which is being developed for the treatment of infectious and autoimmune diseases. HPs are dual antibody conjugates, composed of a monoclonal antibody (mAb) directed against the complement r
Autor:
Stephen N. Jones, Anna M. Cerny, Nehal Mohamed, Robert W. Finberg, Anne Nicholson-Weller, Leslie S. Casey, Steven M. Jones, Alexander Repik, Steve E. Pincus, Lloyd B. Klickstein, Damon R. Asher, George L. Spitalny, Ionita Ghiran
Publikováno v:
Clinical and experimental immunology. 140(2)
Summary Complement receptor 1 (CR1) on the surface of human erythrocytes facilitates intravascular clearance of complement-opsonized pathogens. The need for complement activation can be circumvented by directly coupling the organism to CR1 using a bi
Autor:
Sheena H. Wang, Neil L. Sparks, Richard S. Dondero, W. Michael Foster, Susan K. Hollingshead, Anthony J. Hickey, Herman F. Staats, William M. Gwinn, Catherine R. Doil, Shaun M. Kirwan, David E. Briles, Tom G. Tlusty, Leslie S. Casey, Kathleen A. Ashcraft
Publikováno v:
Vaccine. 29:2821
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7571, USA Department of Medicine, Duke University Medical Center, Durham, N
Autor:
Giorgio Inghirami, Xin Zhang, George L. Spitalny, Juan Li, Steve E. Pincus, Wu Peng, Andrew L. Pecora, Linda L. Nardone, Leslie S. Casey, Kenichi Takeshita
Publikováno v:
Blood. 104:1402-1402
Complement-dependent cytotoxicity (CDC) is a key mechanism of Rituximab® (RTX) action in killing Non-Hodgkin’s Lymphoma (NHL) cells both in vitro and in vivo. Here we present studies of a mouse/human chimeric monoclonal antibody (Mab), ETI-210, sp