Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Leslie R. Ellis"'
Autor:
Rebecca Anderson, Lance D. Miller, Scott Isom, Jeff W. Chou, Kristin M. Pladna, Nathaniel J. Schramm, Leslie R. Ellis, Dianna S. Howard, Rupali R. Bhave, Megan Manuel, Sarah Dralle, Susan Lyerly, Bayard L. Powell, Timothy S. Pardee
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Combining cytarabine and mitoxantrone with the tricarboxylic acid cycle inhibitor devimistat has been reported in a phase I clinical trial with relapsed or refractory acute myeloid leukaemia (AML). Here, the authors report the outcomes of a phase II
Externí odkaz:
https://doaj.org/article/af7e039587ff405b8de70ccdba887ce2
Publikováno v:
MedEdPORTAL, Vol 18 (2022)
Introduction Increasingly, use of the electronic health record (EHR) is interwoven into even the most basic patient care tasks. Accordingly, learning how to utilize the EHR during patient encounters is important for medical students as they develop t
Externí odkaz:
https://doaj.org/article/d3140ae841b54f169de20a2b939f8de5
Autor:
Daniel R. Reed, Margaux Wooster, Scott Isom, Leslie R. Ellis, Dianna S. Howard, Megan Manuel, Sarah Dralle, Susan Lyerly, Rupali Bhave, Bayard L. Powell, Timothy S. Pardee
Publikováno v:
Annals of Hematology. 102:897-906
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0a8c0428de6d5895763597efce91dd8
https://doi.org/10.1007/s00277-023-05141-5
https://doi.org/10.1007/s00277-023-05141-5
Autor:
Bayard L. Powell, Susan Lyerly, Sarah Dralle, Megan Manuel, David D. Hurd, Dianna S. Howard, Dmitriy Berenzon, Leslie R. Ellis, Wei Zhang, Guangxu Jin, Jeff W. Chou, Lance D. Miller, Lais P. Ghiraldeli, Scott Isom, Kristin M. Pladna, Rebecca G. Anderson, Timothy S. Pardee
Figure S1. Dose escalation schema. Figure S2. Acetyl-CoA synthetase is expressed in OCI-AML3 and MFL2 cells. Figure S3 Acetate and methyl-succinate rescue of CPI-613 cytotoxicity. Figure S4. Treatment schema. Figure S5. Efficacy of HiDAC, mitoxantron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa013db81e0b8aa200a02dd48f34207
https://doi.org/10.1158/1078-0432.22463990.v1
https://doi.org/10.1158/1078-0432.22463990.v1
Autor:
Bayard L. Powell, Susan Lyerly, Sarah Dralle, Megan Manuel, Robin Harrelson, Leslie R. Ellis, David Hurd, Denise Levitan, Kristin M. Stadelman, Lance D. Miller, Scott Isom, Robert Rodriguez, Claudia Maturo, John Luddy, King Lee, Timothy S. Pardee
Purpose: The lipoate derivative CPI-613 is a first-in-class agent that targets mitochondrial metabolism. This study determined the effects of CPI-613 on mitochondrial function and defined the MTD, pharmacokinetics, and safety in patients with relapse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94274ada13dbd409c8c48fe4c2e450f
https://doi.org/10.1158/1078-0432.c.6523629
https://doi.org/10.1158/1078-0432.c.6523629
Autor:
Bayard L. Powell, Susan Lyerly, Sarah Dralle, Megan Manuel, David D. Hurd, Dianna S. Howard, Dmitriy Berenzon, Leslie R. Ellis, Wei Zhang, Guangxu Jin, Jeff W. Chou, Lance D. Miller, Lais P. Ghiraldeli, Scott Isom, Kristin M. Pladna, Rebecca G. Anderson, Timothy S. Pardee
Purpose: CPI-613, a lipoate analogue that inhibits pyruvate dehydrogenase (PDH) and α-ketogluterate dehydrogenase (KGDH), has activity in patients with myeloid malignancies. This study explored the role of mitochondrial metabolism in chemotherapy re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa6abca3e8f8542b007234c73ae901b
https://doi.org/10.1158/1078-0432.c.6525593.v1
https://doi.org/10.1158/1078-0432.c.6525593.v1
Autor:
Bayard L. Powell, Susan Lyerly, Sarah Dralle, Megan Manuel, Robin Harrelson, Leslie R. Ellis, David Hurd, Denise Levitan, Kristin M. Stadelman, Lance D. Miller, Scott Isom, Robert Rodriguez, Claudia Maturo, John Luddy, King Lee, Timothy S. Pardee
Supplementary Figure 2. Differential gene expression between responders and non-responders. The top 50 genes up regulated in responders (left side) or non-responders (right side) in PBMCs from 4 responders compared to 4 non-responders taken on day 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f2ff7c7bc3ec05fd622c1bd00e4f3a
https://doi.org/10.1158/1078-0432.22457616
https://doi.org/10.1158/1078-0432.22457616
Autor:
Matthew L Chase, Reed Drews, Marc Zumberg, Leslie R Ellis, Erin G Reid, Aaron T Gerds, Alfred I Lee, Gabriela Hobbs, Jonathan Berry, Jason A Freed
Publikováno v:
Blood Advances.
Graduate medical education training in hematology in North America is accredited by the Accreditation Council for Graduate Medical Education (ACGME). Trainees routinely review peripheral blood smears (PBS) in providing clinical care. Competency in PB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d9630198c88806178b41f2a0aaac48d
https://doi.org/10.1182/bloodadvances.2023009843
https://doi.org/10.1182/bloodadvances.2023009843
Autor:
Matthew L Chase, Reed E. Drews, Alfred I Lee, Erin G Reid, Aaron T. Gerds, Gabriela S. Hobbs, Leslie R Ellis, Marc S Zumberg, Jonathan Berry, Jason A Freed
Publikováno v:
Blood. 140:10781-10783
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5a1d62205dd9ebbf97870f7ef81402f
https://doi.org/10.1182/blood-2022-159990
https://doi.org/10.1182/blood-2022-159990
Autor:
Susan Lyerly, Megan Manuel, Rupali Bhave, Leslie R. Ellis, Ryan Woods, Timothy S. Pardee, Mary Beth Seegars, Bayard L. Powell, Dianna S. Howard, Sarah Dralle
Publikováno v:
Journal of Hematology
Background: Resistance to therapy and a poor outcome characterize relapsed or refractory acute myeloid leukemia (AML). There is a clear need for additional palliative approaches with acceptable toxicities. Vincristine sulfate liposome injection (VSLI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0070816719c391208e35cacda101c0
https://doi.org/10.14740/jh771
https://doi.org/10.14740/jh771