Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Leslie Oleksowicz"'
Autor:
Leslie Oleksowicz, Zhongyun Dong, Yin Liu, Shan Lu, R. Bruce Bracken, Paul A. Succop, Barbara Burke, Linda Levin, Krishnanath Gaitonde
Publikováno v:
The Prostate. 72:1140-1149
BACKGROUND Our previous study showed that prostate cancer cells overexpress and secrete secretory phospholipases A2 group IIa (sPLA2-IIa) and plasma sPLA2-IIa was elevated in prostate cancer patients. The current study further explored the underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041e97e019f3a47d1840be4655533e7a
https://doi.org/10.1002/pros.22463
https://doi.org/10.1002/pros.22463
Autor:
Zhongyun Dong, Leslie Oleksowicz, Qihui Jim Zhai, R. Bruce Bracken, Krishnanath Gaitonde, Jiang Wang, Yin Liu, Kieran F. Scott, Shan Lu, Barbara Burke, Linda Levin
Publikováno v:
Carcinogenesis. 31:1948-1955
The majority of prostate cancers are indolent, whereas a significant portion of patients will require systemic treatment during the course of their disease. To date, only high Gleason scores are best associated with a poor prognosis in prostate cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c21c19185e16b06d57c86172e4dc33
https://doi.org/10.1093/carcin/bgq188
https://doi.org/10.1093/carcin/bgq188
Autor:
Alexandra S. Bailey, Jeffrey A. Sosman, Su Chun Cheng, Bradley C. Leibovich, Michael Ka Keu Wong, Rupal S. Bhatt, Eugene D. Kwon, Leslie Oleksowicz, Joseph I. Clark, Leonard Joseph Appleman, Sabina Signoretti, Robert A. Figlin, Marc S. Ernstoff, David F. McDermott, Ulka N. Vaishampayan, Nikhil I. Khushalani, James W. Mier, Kim Margolin, Brendan D. Curti, Theodore F. Logan, David J. Panka, Allan J. Pantuck, Janice P. Dutcher, Fairooz F. Kabbinavar, Michael B. Atkins, Arie S. Belldegrun, Meredith M. Regan
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 21, iss 3
Purpose: High-dose aldesleukin (HD IL2) received FDA approval for the treatment of metastatic renal cell carcinoma (MRCC) in 1992, producing a 14% objective response rate (ORR) and durable remissions. Retrospective studies suggested that clinical and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2132908adce0df8dc2fb6f2c3bbd5809
https://pubmed.ncbi.nlm.nih.gov/25424850
https://pubmed.ncbi.nlm.nih.gov/25424850
Autor:
Janice P. Dutcher, Leslie Oleksowicz
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 125:101-108
Purpose: High-dose bolus interleukin-2 (IL-2) is currently the sole agent approved by the Food and Drug Administration for the treatment of advanced renal cell carcinoma. This phase II study was designed to evaluate the clinical activity and toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4ea074672d01c3039935f874b5380a
https://doi.org/10.1007/s004320050249
https://doi.org/10.1007/s004320050249
Publikováno v:
Experimental Cell Research. 237:110-117
Fresh frozen breast carcinoma tissues were examined for the presence of GPIb alpha by immunohistochemistry. GPIb alpha was detected in six of seven primary invasive intraductal breast carcinoma tissues whereas staining was negative in seven of seven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43923ba870365623f1b1308187c40994
https://doi.org/10.1006/excr.1997.3784
https://doi.org/10.1006/excr.1997.3784
Autor:
Michael J. Borowitz, Peter H. Wiernik, Janice P. Dutcher, Leslie Oleksowicz, Ummekalsoom R. Malik, Howard Ratech
Publikováno v:
Medical Oncology. 13:207-213
An atypical case of infectious mononucleosis characterized by fever, acute tonsillitis, and bilateral cervical adenopathy is reported in a previously healthy young man. Although serology was positive for the Epstein-Barr virus, the patient did not di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267815fd84e3a4afef1698427e10593a
https://doi.org/10.1007/bf02990933
https://doi.org/10.1007/bf02990933
Autor:
Manoochehr Khorshidi, Zbigniew Mrowiec, Leslie Oleksowicz, Janice P. Dutcher, E G Puszkin, Edward L. Schwartz
Publikováno v:
Thrombosis Research. 79:261-274
Tumor cell induced platelet aggregation is thought to be an early step in the metastatic process. Here we show that platelet aggregation induced by MCF-7 cells is mediated, in part, through an ADP-dependent mechanism based on inhibition of aggregatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711a37f10526bf22a947d9f44bdb088f
https://doi.org/10.1016/0049-3848(95)00113-6
https://doi.org/10.1016/0049-3848(95)00113-6
Autor:
James H. Doroshow, Elizabeth Trehu, Geoffrey R. Weiss, Randi Isaacs, Janice P. Dutcher, Kim Margolin, Richard I. Fisher, Michael B. Atkins, M Sznol, Leslie Oleksowicz, Jeffrey A. Sosman
Publikováno v:
Journal of Immunotherapy. 18:52-56
IL-6 is a pluripotent cytokine with stimulatory effects on megakaryocytes, B lymphocytes, and (in combination with other cytokines) committed hematopoietic stem cells and T cells. IL-6 has direct antitumor activity against murine tumors. We previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dac7f5a578af635fb973955e6006bea
https://doi.org/10.1097/00002371-199507000-00007
https://doi.org/10.1097/00002371-199507000-00007
Autor:
Leslie Oleksowicz, Janice P. Dutcher
Publikováno v:
American Journal of Therapeutics. 1:107-115
The interleukins function as intercellular hormones, possessing the ability to alter the activity of a target cell population. Interleukin-4, secreted by activated T-cells, has shown antitumor activity in vitro against multiple myelomas, lymphoma, ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21228300a7c99dbbe21474ae6c9202c5
https://doi.org/10.1097/00045391-199408000-00002
https://doi.org/10.1097/00045391-199408000-00002
Autor:
Janice P. Dutcher, Leslie Oleksowicz, Usha Venkatraj, Joseph A. Sparano, Kevin P. O'Boyle, Peter H. Wiernik
Publikováno v:
Clinical Immunotherapeutics. 1:271-281
The interleukins function as intercellular hormones, and have the capacity to alter the activity of a target cell population. Immunotherapy with interleukin-2 (IL-2) constitutes a new treatment strategy for malignancies otherwise not responsive to tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15aee54334520712e8dc6903aec12139
https://doi.org/10.1007/bf03259253
https://doi.org/10.1007/bf03259253