Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Leslie Naranjo"'
Autor:
Nileena Velappan, Fortunato Ferrara, Sara D'Angelo, Devin Close, Leslie Naranjo, Madeline R Bolding, Sarah C Mozden, Camille B Troup, Donna K McCullough, Analyssa Gomez, Marijo Kedge, Andrew R M Bradbury
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0280930 (2023)
Antibodies are important reagents for research, diagnostics, and therapeutics. Many examples of chimeric proteins combining the specific target recognition of antibodies with complementing functionalities such as fluorescence, toxicity or enzymatic a
Externí odkaz:
https://doaj.org/article/11a2f16525564b46ab218f4b5b96ed0c
Autor:
Andre A. R. Teixeira, Sara D’Angelo, M. Frank Erasmus, Camila Leal-Lopes, Fortunato Ferrara, Laura P. Spector, Leslie Naranjo, Esteban Molina, Tamara Max, Ashley DeAguero, Katherine Perea, Shaun Stewart, Rebecca A. Buonpane, Horacio G. Nastri, Andrew R. M. Bradbury
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Affinity maturation is often a necessary step for the development of potent therapeutic molecules. Many different diversification strategies have been used for antibody affinity maturation, including error-prone PCR, chain shuffling, and targeted com
Externí odkaz:
https://doaj.org/article/33ec78a25c5c442aa8059bd64ee24afc
Autor:
M. Frank Erasmus, Sara D’Angelo, Fortunato Ferrara, Leslie Naranjo, André A. Teixeira, Rebecca Buonpane, Shaun M. Stewart, Horacio G. Nastri, Andrew R. M. Bradbury
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Here, the authors construct and validate an in vitro antibody library from a single, healthy donor. They demonstrate the functionality of the library using several therapeutically relevant targets and were able to obtain many different antibodies wit
Externí odkaz:
https://doaj.org/article/97589959248d40069c6d04e7cbd5a7d0
Autor:
Nileena Velappan, Avanika Mahajan, Leslie Naranjo, Priyanka Velappan, Nasim Andrews, Nicholas Tiee, Subhendu Chakraborti, Colin Hemez, Tiziano Gaiotto, Bridget Wilson, Andrew Bradbury
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1206-1218 (2019)
Post-translational modifications, such as the phosphorylation of tyrosines, are often the initiation step for intracellular signaling cascades. Pan-reactive antibodies against modified amino acids (e.g., anti-phosphotyrosine), which are often used to
Externí odkaz:
https://doaj.org/article/10edd85e6c9b4e6fb382d9d01fc06caf
Autor:
Andre Azevedo Reis Teixeira, Michael Frank Erasmus, Sara D’Angelo, Leslie Naranjo, Fortunato Ferrara, Camila Leal-Lopes, Oliver Durrant, Cecile Galmiche, Aleardo Morelli, Anthony Scott-Tucker, Andrew Raymon Morton Bradbury
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Therapeutic antibodies must have “drug-like” properties. These include high affinity and specificity for the intended target, biological activity, and additional characteristics now known as “developability properties”: long-term stability an
Externí odkaz:
https://doaj.org/article/3efb39488f134ef39b97826420fa5fc9
Autor:
Fortunato Ferrara, Andre A. Teixeira, Leslie Naranjo, M. Frank Erasmus, Sara D’Angelo, Andrew R.M. Bradbury
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Antibody discovery using invitro display technologies such as phage and/or yeast display has become acornerstone in many research and development projects, including the creation of new drugs for clinical use. Traditionally, after the selection phase
Externí odkaz:
https://doaj.org/article/e78f6f9659eb4a288932eefe0be9c05d
Autor:
Sara D’Angelo, Fortunato Ferrara, Leslie Naranjo, M. Frank Erasmus, Peter Hraber, Andrew R. M. Bradbury
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Because of its great potential for diversity, the immunoglobulin heavy-chain complementarity-determining region 3 (HCDR3) is taken as an antibody molecule’s most important component in conferring binding activity and specificity. For this reason, H
Externí odkaz:
https://doaj.org/article/4aca73f2004c476eae6e3e06b8cae5fe
Autor:
Leslie Naranjo, Fortunato Ferrara, Nicolas Blanchard, Caroline Demangel, Sara D’Angelo, M. Frank Erasmus, Andre A. Teixeira, Andrew R.M. Bradbury
Publikováno v:
Toxins, Vol 11, Iss 6, p 346 (2019)
In the past, it has proved challenging to generate antibodies against mycolactone, the primary lipidic toxin A of Mycobacterium ulcerans causing Buruli ulcer, due to its immunosuppressive properties. Here we show that in vitro display, comprising bot
Externí odkaz:
https://doaj.org/article/6397eaab92fe4963b3aa3501760c0bc5
Autor:
M Lisa Phipps, Antoinetta M Lillo, Yulin Shou, Emily N Schmidt, Chad D Paavola, Leslie Naranjo, Sara Bemdich, Basil I Swanson, Andrew R M Bradbury, Jennifer S Martinez
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0160940 (2016)
Peptides are important affinity ligands for microscopy, biosensing, and targeted delivery. However, because they can have low affinity for their targets, their selection from large naïve libraries can be challenging. When selecting peptidic ligands
Externí odkaz:
https://doaj.org/article/a14a429d1cf94888b031aa2aef531c09
Autor:
Priyanka Velappan, Andrew Bradbury, Colin Hemez, Nasim Andrews, Nicholas Tiee, Subhendu Chakraborti, Bridget S. Wilson, Leslie Naranjo, Avanika Mahajan, Nileena Velappan, Tiziano Gaiotto
Publikováno v:
mAbs
Post-translational modifications, such as the phosphorylation of tyrosines, are often the initiation step for intracellular signaling cascades. Pan-reactive antibodies against modified amino acids (e.g., anti-phosphotyrosine), which are often used to