Výsledky vyhledávání - "Leslie Michels Thompson"

Akademický článek

Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid

Autor: Jessica Pilar McLin, Leslie Michels Thompson, Aldons J. Lusis, Richard C. Davis, Oswald Steward

Publikováno v: Neurobiology of Disease, Vol 29, Iss 3, Pp 391-399 (2008)

Previous studies have provided evidence that a quantitative trait locus (QTL) on the distal part of chromosome 18 (chr18) is a major determinant of vulnerability to hippocampal neurodegeneration following kainic acid (KA)-induced seizures in inbred m

Externí odkaz: https://doaj.org/article/f59fdd7df1ad4fb59e4a0838dfecb1cf

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Akademický článek

Fibroblast growth factor receptor 3 interacts with and activates TGFβ-activated kinase 1 tyrosine phosphorylation and NFκB signaling in multiple myeloma and bladder cancer.

Autor: Lisa Salazar, Tamara Kashiwada, Pavel Krejci, April N Meyer, Malcolm Casale, Matthew Hallowell, William R Wilcox, Daniel J Donoghue, Leslie Michels Thompson

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e86470 (2014)

Cancer is a major public health problem worldwide. In the United States alone, 1 in 4 deaths is due to cancer and for 2013 a total of 1,660,290 new cancer cases and 580,350 cancer-related deaths are projected. Comprehensive profiling of multiple canc

Externí odkaz: https://doaj.org/article/60a18b4f04b5441ba8513893423db09c

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Akademický článek

Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage.

Autor: Pavel Krejci, Lisa Salazar, Tamara A Kashiwada, Katarina Chlebova, Alena Salasova, Leslie Michels Thompson, Vitezslav Bryja, Alois Kozubik, William R Wilcox

Publikováno v: PLoS ONE, Vol 3, Iss 12, p e3961 (2008)

Activating mutations in FGFR3 tyrosine kinase cause several forms of human skeletal dysplasia. Although the mechanisms of FGFR3 action in cartilage are not completely understood, it is believed that the STAT1 transcription factor plays a central role

Externí odkaz: https://doaj.org/article/05d9a687bded42dbbc7fcef01db7e7b0

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Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease

Autor: Laszlo, Bodai, Judit, Pallos, Leslie Michels, Thompson, J Lawrence, Marsh

Publikováno v: Neuro-degenerative diseases. 9(2)

Huntingtin peptides with elongated polyglutamine domains, the root causes of Huntington's disease, hinder histone acetylation, which leads to transcriptional dysregulation. However, the range of acetyltransferases interacting with mutant Huntingtin h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ccfba8eb955b888af62d1b2050279a24
https://pubmed.ncbi.nlm.nih.gov/21912091

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