Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Leslie M. Tompkins"'
Autor:
Linhao Li, Takeo Nakanishi, Hongbing Wang, Caitlin Lynch, Douglas D. Ross, Yi Xie, Haishan Li, Leslie M. Tompkins
Publikováno v:
Biochemical Pharmacology. 80:1754-1761
Induction of the breast cancer resistance protein (BCRP/ABCG2) expression has been found in various tissues and cell-types after exposure to chemicals including 17β-estradiol, rosiglitazone, imatinib, as well as aryl hydrocarbon receptor (AhR) activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc20ad7944dc3679b90bad78519e803e
https://doi.org/10.1016/j.bcp.2010.08.016
https://doi.org/10.1016/j.bcp.2010.08.016
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 332:106-115
The constitutive androstane receptor (CAR) is constitutively activated in immortalized cell lines independent of xenobiotic stimuli. This feature of CAR has limited its use as a sensor for xenobiotic-induced expression of drug-metabolizing enzymes. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843ae2981aea0d8aa8074c6a52b0687b
https://doi.org/10.1124/jpet.109.159210
https://doi.org/10.1124/jpet.109.159210
Autor:
Leslie M Tompkins, Hongbing Wang
Publikováno v:
Current Drug Metabolism. 9:598-610
Human CYP2B6 has been thought to account for a minor portion (< 1%) of total hepatic cytochrome P450 (CYP) content and to have a minor function in human drug metabolism. Recent studies, however, indicate that the average relative contribution of CYP2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458d31fac4190fbb51d8937e9b5047ff
https://doi.org/10.2174/138920008785821710
https://doi.org/10.2174/138920008785821710
Autor:
Hongbing Wang, Leslie M. Tompkins
Publikováno v:
Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44bb814cad85d9d1f3cb68a4f6e629d9
https://doi.org/10.1002/9781118067598.ch10
https://doi.org/10.1002/9781118067598.ch10
Purpose The objective of this investigation was to assess whether common pharmaceutical excipients regulate the expression of drug-metabolizing enzymes in human colon and liver cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d4e3a96fca0a36e8c245357f8410c3
https://europepmc.org/articles/PMC3718039/
https://europepmc.org/articles/PMC3718039/
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 36(5)
The pregnane X receptor (PXR) is known as the xenosensing receptor responsible for coordinated regulation of metabolic genes in response to diverse xenobiotic challenges. In particular, the ability of the PXR to regulate CYP3A4, the enzyme capable of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b545414c9a7dbd381729afefa2d471bd
https://pubmed.ncbi.nlm.nih.gov/18276839
https://pubmed.ncbi.nlm.nih.gov/18276839
Autor:
Leslie M. Tompkins, Andrew D. Wallace
Publikováno v:
Journal of biochemical and molecular toxicology. 21(4)
Cytochrome P450s (CYPs) are important heme-containing proteins that play important roles in the metabolism of xenobiotics and endogenous compounds. The oxidative metabolisms of drugs, environmental chemicals, hormones, and fatty acids by CYP enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feffeef8d13c78f98271db333f31c16a
https://pubmed.ncbi.nlm.nih.gov/17936931
https://pubmed.ncbi.nlm.nih.gov/17936931