Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Leslie M. Jonart"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Central nervous system (CNS) relapse is a significant cause of treatment failure among patients with acute lymphoblastic leukemia. In prior work we found that the meninges, the thin layer of tissue that covers the brain and spinal cord, harb
Externí odkaz:
https://doaj.org/article/2de1b920152043c28d8ada5d61e60d84
Autor:
Leslie M. Jonart, Maryam Ebadi, Patrick Basile, Kimberly Johnson, Jessica Makori, Peter M. Gordon
Publikováno v:
Haematologica, Vol 105, Iss 8 (2020)
Protection from acute lymphoblastic leukemia relapse in the central nervous system (CNS) is crucial to survival and quality of life for leukemia patients. Current CNS-directed therapies cause significant toxicities and are only partially effective. M
Externí odkaz:
https://doaj.org/article/695932877ba445e2818afbc5bfd89eb2
Autor:
Jeffrey S. Gaynes, Leslie M. Jonart, Edward A. Zamora, Jordan A. Naumann, Nathan P. Gossai, Peter M. Gordon
Publikováno v:
Haematologica, Vol 102, Iss 4 (2017)
Externí odkaz:
https://doaj.org/article/4f7d7636823c42c1b37c5b8dfc0ec01c
Autor:
Leslie M. Jonart, Jason Ostergaard, Athena Brooks, Garrett Fitzpatrick, Liam Chen, Peter M. Gordon
Publikováno v:
Br J Haematol
The effective prophylaxis and treatment of central nervous system (CNS) involvement in acute lymphoblastic leukaemia (ALL) remains a significant clinical challenge. Developing novel and more effective CNS-directed therapies has been hampered, in part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df390eef391e91cbb651044837bee62c
https://europepmc.org/articles/PMC10121760/
https://europepmc.org/articles/PMC10121760/
Autor:
Jason Ostergaard, David Gordon, Leslie M. Jonart, Stacia L. Koppenhafer, Peter M. Gordon, Maryam Ebadi
Publikováno v:
Br J Haematol
The addition of molecularly targeted therapies to current chemotherapy regimens may improve acute lymphoblastic leukemia (ALL) outcomes and reduce acute and late toxicities. Checkpoint kinase 1 (CHK1) orchestrates cell cycle checkpoint control in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fcd63bb7441a7efd1bce74a64a19c9
https://doi.org/10.1111/bjh.17610
https://doi.org/10.1111/bjh.17610
Autor:
Peter M. Gordon, Jason Ostergaard, Leslie M. Jonart, M Frank Erasmus, Bridget S. Wilson, Stuart S. Winter
Publikováno v:
Blood. 140:9201-9202
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6733829e135e11bbf2957227968cefb3
https://doi.org/10.1182/blood-2022-159115
https://doi.org/10.1182/blood-2022-159115
Autor:
Leslie M. Jonart, Peter M. Gordon, Morgan Kerfeld, Maryam Ebadi, Kimberly J. Johnson, Patrick Basile
Publikováno v:
Br J Haematol
Central nervous system (CNS) relapse is a common cause of treatment failure in patients with acute lymphoblastic leukaemia (ALL) despite current CNS-directed therapies that are also associated with significant short- and long-term toxicities. Herein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e75df907b61813d868f93fe0c8f77f9
https://doi.org/10.1111/bjh.16270
https://doi.org/10.1111/bjh.16270
Autor:
Kimberly Johnson, Leslie M. Jonart, Jessica Makori, Peter M. Gordon, Maryam Ebadi, Patrick Basile
Publikováno v:
Haematologica
Protection from acute lymphoblastic leukemia (ALL) relapse in the central nervous system (CNS) is crucial to survival and quality of life for ALL patients. Current CNS-directed therapies cause significant toxicities and are only partially effective.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a1c6cfa5f7e60a3156eacff92e20de
http://europepmc.org/articles/PMC7395284
http://europepmc.org/articles/PMC7395284
Autor:
Jordan A. Naumann, Daniel A. Harki, Peter M. Gordon, Maryam Ebadi, Jian Tang, Leslie M. Jonart, John C. Widen, David Gordon
Publikováno v:
Bioconjug Chem
The limited delivery of chemotherapy agents to cancer cells and the nonspecific action of these agents are significant challenges in oncology. We have previously developed a customizable drug delivery and activation system in which a nucleic acid fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894b090089c3b2e4526b023d06dfff8b
https://doi.org/10.1021/acs.bioconjchem.7b00774
https://doi.org/10.1021/acs.bioconjchem.7b00774
Autor:
Leslie M. Jonart, Morgan Kerfeld, Kimberly J. Johnson, Patrick Basile, Maryam Ebadi, Peter M. Gordon
Central nervous system (CNS) relapse is a common cause of treatment failure in patients with acute lymphoblastic leukemia (ALL) despite current CNS-directed therapies that are also associated with significant short and long-term toxicities. Herein, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498ab29b9c744f265d0a998f3d2941da
https://doi.org/10.1101/750513
https://doi.org/10.1101/750513