Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Leslie M. Fischer"'
Autor:
Lisa A. Sutherland, Leslie M. Fischer, Lori A. Kaley, Clare M. Hasler, Jeffrey B. Blumberg, Mark A. Kantor, Tracy A. Fox, Jeremy Nobel
Publikováno v:
American Journal of Health Promotion. 26:e55-e63
Purpose. To describe the collaborative process between a grocery retailer and a panel of nutrition experts used to develop a nutrition guidance system (Guiding Stars) that evaluates the nutrient profile of all edible products in the supermarket, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bf0502a6ae5dc24170d4a327c58ce3
https://doi.org/10.4278/ajhp.100709-qual-238
https://doi.org/10.4278/ajhp.100709-qual-238
Autor:
Robert W. Reid, Timothy J. Hamp, Melanie D. Spencer, Steven H. Zeisel, Anthony A. Fodor, Leslie M. Fischer
Publikováno v:
Gastroenterology. 140:976-986
Background & Aims Nonalcoholic fatty liver disease affects up to 30% of the US population, but the mechanisms underlying this condition are incompletely understood. We investigated how diet standardization and choline deficiency influence the composi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7989c9799ba592c6eb8ef6a7d2952600
https://doi.org/10.1053/j.gastro.2010.11.049
https://doi.org/10.1053/j.gastro.2010.11.049
Publikováno v:
The American Journal of Clinical Nutrition. 92:1113-1119
Background: Choline is obtained from the diet and from the biosynthesis of phosphatidylcholine. Phosphatidylcholine is catalyzed by the enzyme phosphatidylethanolamine-N-methyltransferase (PEMT), which is induced by estrogen. Because they have lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd0c9d469973cd0f7869fa859619b2c
https://doi.org/10.3945/ajcn.2010.30064
https://doi.org/10.3945/ajcn.2010.30064
Autor:
Leslie M. Fischer, Steven H. Zeisel, Michael V. Milburn, Wei Jia, Kerry Ann Da Costa, Wei Sha, Kay A. Lawton, Alvin Berger
Publikováno v:
The FASEB Journal. 24:2962-2975
Choline is an essential nutrient, and deficiency causes liver and muscle dysfunction. Common genetic variations alter the risk of developing organ dysfunction when choline deficient, probably by causing metabolic inefficiencies that should be detecta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dda18d043b013cd87d8c222e524b888
https://doi.org/10.1096/fj.09-154054
https://doi.org/10.1096/fj.09-154054
Autor:
Zhong Guo, Leslie M. Fischer, Mihai D. Niculescu, Corneliu N. Craciunescu, Steven H. Zeisel, Amy R. Johnson
Publikováno v:
Toxicological Sciences. 107:220-226
Diethanolamine (DEA) is a common ingredient of personal care products. Dermal administration of DEA diminishes hepatic stores of the essential nutrient choline and alters brain development. We previously reported that 80 mg/kg/day of DEA during pregn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09080ad266afa6b0bd599fd8fccf4b7b
https://doi.org/10.1093/toxsci/kfn227
https://doi.org/10.1093/toxsci/kfn227
Publikováno v:
The American Journal of Clinical Nutrition. 86:230-239
Some humans fed a low-choline diet develop hepatosteatosis, liver and muscle damage, and lymphocyte apoptosis. The risk of developing such organ dysfunction is increased by the presence of single-nucleotide polymorphisms (SNPs) in genes involved in f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684f9528ea478aa7f0642e2ac5e43108
https://doi.org/10.1093/ajcn/86.1.230
https://doi.org/10.1093/ajcn/86.1.230
Autor:
Leslie M. Fischer, Paul W. Stewart, Lester Kwock, Sally P. Stabler, Steven H. Zeisel, Tsui Shan Lu, Kerry Ann daCosta, Robert H. Allen
Publikováno v:
The American Journal of Clinical Nutrition. 85:1275-1285
Background Although humans require dietary choline for methyl donation, membrane function, and neurotransmission, choline can also be derived from the de novo synthesis of phosphatidylcholine, which is up-regulated by estrogen. A recommended Adequate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6932a80271046ddb1d6da8f0bebfdc57
https://doi.org/10.1093/ajcn/85.5.1275
https://doi.org/10.1093/ajcn/85.5.1275
Publikováno v:
Proceedings of the National Academy of Sciences. 102:16025-16030
Choline is a required nutrient, and some humans deplete quickly when fed a low-choline diet, whereas others do not. Endogenous choline synthesis can spare some of the dietary requirement and requires one-carbon groups derived from folate metabolism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f2b6742f2b2efbb11c8ab903a1756c
https://doi.org/10.1073/pnas.0504285102
https://doi.org/10.1073/pnas.0504285102
Autor:
Lester Kwock, Martin Kohlmeier, Jiannan Song, Steven H. Zeisel, Kerry Ann Da Costa, Shuli Wang, Leslie M. Fischer
Publikováno v:
The FASEB Journal. 19:1266-1271
Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes phosphatidylcholine synthesis. PEMT knockout mice have fatty livers, and it is possible that, in humans, nonalcoholic fatty liver disease (NAFLD) might be associated with PEMT gene polymor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba760cf740d458159d89734ec927477
https://doi.org/10.1096/fj.04-3580com
https://doi.org/10.1096/fj.04-3580com
Autor:
Kerry Ann Da Costa, Marjorie G Busby, Steven H. Zeisel, Leslie M. Fischer, Mei Heng Mar, Dorothene Thompson
Publikováno v:
Journal of the American Dietetic Association. 104:1836-1845
This article describes the development of a series of choline- and betaine-controlled diets that were served to research subjects as part of an ongoing study of diet requirements in humans. These diets were developed based on the analysis of choline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7633bd7f3d1d9a9e44f75d628932d4
https://doi.org/10.1016/j.jada.2004.09.027
https://doi.org/10.1016/j.jada.2004.09.027