Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Leslie M. Cope"'
Autor:
Christine M. O'Keefe, Yang Zhao, Leslie M. Cope, Chih‐Ming Ho, Amanda N. Fader, Rebecca Stone, James S. Ferris, Anna Beavis, Kimberly Levinson, Stephanie Wethington, Tian‐Li Wang, Thomas R. Pisanic, Ie‐Ming Shih, Tza‐Huei Wang
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 8, Pp n/a-n/a (2024)
Abstract Recent advances in molecular analyses of ovarian cancer have revealed a wealth of promising tumour‐specific biomarkers, including protein, DNA mutations and methylation; however, reliably detecting such alterations at satisfactorily high s
Externí odkaz:
https://doaj.org/article/9aace26585f240c7a1a7284b98330d63
Autor:
Lionel Chia, Bowen Wang, Jung-Hyun Kim, Li Z. Luo, Shuai Shuai, Iliana Herrera, Sophia Y. Chen, Liping Li, Lingling Xian, Tait Huso, Mohammad Heydarian, Karen Reddy, Woo Jung Sung, Shun Ishiyama, Gongbo Guo, Elizabeth Jaffee, Lei Zheng, Leslie M. Cope, Kathy Gabrielson, Laura Wood, Linda Resar
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
High mobility group A1 (HMGA1) chromatin regulators are upregulated in diverse tumors where they portend adverse outcomes, although how they function in cancer remains unclear. Pancreatic ductal adenocarcinomas (PDACs) are highly lethal tumors charac
Externí odkaz:
https://doaj.org/article/309e97a7809b4c8b872864ba59ca2243
Autor:
Juanjuan Li, Bradley M. Downs, Leslie M. Cope, Mary Jo Fackler, Xiuyun Zhang, Chuan-gui Song, Christopher VandenBussche, Kejing Zhang, Yong Han, Yufei Liu, Suzana Tulac, Neesha Venkatesan, Timothy de Guzman, Chuang Chen, Edwin W. Lai, Jingping Yuan, Saraswati Sukumar
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract Preoperative staging of suspicious axillary lymph nodes (ALNs) allows patients to be triaged to ALN dissection or to sentinel lymph node biopsy (SLNB). Ultrasound-guided fine needle aspiration (FNA) and cytology of ALN is moderately sensitiv
Externí odkaz:
https://doaj.org/article/86a221899d2a40bf8a198d08bfddb605
Autor:
Mary Jo Fackler, Suzana Tulac, Neesha Venkatesan, Adam J. Aslam, Timothy N. de Guzman, Claudia Mercado-Rodriguez, Leslie M. Cope, Bradley M. Downs, Abdul Hussain Vali, Wanjun Ding, Jennifer Lehman, Rita Denbow, Jeffrey Reynolds, Morgan E. Buckley, Kala Visvanathan, Christopher B. Umbricht, Antonio C. Wolff, Vered Stearns, Michael Bates, Edwin W. Lai, Saraswati Sukumar
Publikováno v:
Cancer Res Commun
Current molecular liquid biopsy assays to detect recurrence or monitor response to treatment require sophisticated technology, highly trained personnel, and a turnaround time of weeks. We describe the development and technical validation of an automa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7caa819910e901535bdf719e430309e9
https://doi.org/10.1158/2767-9764.crc-22-0133
https://doi.org/10.1158/2767-9764.crc-22-0133
Autor:
Saraswati Sukumar, Edwin W. Lai, Michael Bates, Vered Stearns, Antonio C. Wolff, Christopher B. Umbricht, Kala Visvanathan, Morgan E. Buckley, Jeffrey Reynolds, Rita Denbow, Jennifer Lehman, Wanjun Ding, Abdul Hussain Vali, Bradley M. Downs, Leslie M. Cope, Claudia Mercado-Rodriguez, Timothy N. de Guzman, Adam J. Aslam, Neesha Venkatesan, Suzana Tulac, Mary Jo Fackler
The table provides a step by step guide to calculate methylation in each gene followed by cumulative methylation using the algorithm derived in this paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0f0db05a9f6502f4054894de57a4c7
https://doi.org/10.1158/2767-9764.22544640.v1
https://doi.org/10.1158/2767-9764.22544640.v1
Autor:
Saraswati Sukumar, Edwin W. Lai, Michael Bates, Vered Stearns, Antonio C. Wolff, Christopher B. Umbricht, Kala Visvanathan, Morgan E. Buckley, Jeffrey Reynolds, Rita Denbow, Jennifer Lehman, Wanjun Ding, Abdul Hussain Vali, Bradley M. Downs, Leslie M. Cope, Claudia Mercado-Rodriguez, Timothy N. de Guzman, Adam J. Aslam, Neesha Venkatesan, Suzana Tulac, Mary Jo Fackler
Figure shows the perfomance of LBx-BCM in the training set samples. A histogram shows cumulative methylation for each sample, and a box plot shows significnt difference of methylation in serum of metastatic breast cancer patients compared to normal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fbbfde44501db0c5e89a259d2120e9
https://doi.org/10.1158/2767-9764.22544652
https://doi.org/10.1158/2767-9764.22544652
Autor:
Saraswati Sukumar, Edwin W. Lai, Michael Bates, Vered Stearns, Antonio C. Wolff, Christopher B. Umbricht, Kala Visvanathan, Morgan E. Buckley, Jeffrey Reynolds, Rita Denbow, Jennifer Lehman, Wanjun Ding, Abdul Hussain Vali, Bradley M. Downs, Leslie M. Cope, Claudia Mercado-Rodriguez, Timothy N. de Guzman, Adam J. Aslam, Neesha Venkatesan, Suzana Tulac, Mary Jo Fackler
Current molecular liquid biopsy assays to detect recurrence or monitor response to treatment require sophisticated technology, highly trained personnel, and a turnaround time of weeks. We describe the development and technical validation of an automa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149cae505222e663985c162ddc1acce1
https://doi.org/10.1158/2767-9764.c.6550710
https://doi.org/10.1158/2767-9764.c.6550710
Autor:
Tian-Li Wang, Ie-Ming Shih, Tza-Huei Wang, Amanda N. Fader, Kentaro Nakayama, Ryoichi Asaka, Pornpat Athamanolap, Ting-Tai Yen, Shiou-Fu Lin, Leslie M. Cope, Thomas R. Pisanic
Supplementary Tables S1-S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14d4e7bb6805cd5385eeb9a4faa49ee
https://doi.org/10.1158/1078-0432.22468451.v1
https://doi.org/10.1158/1078-0432.22468451.v1
Autor:
Tian-Li Wang, Ie-Ming Shih, Tza-Huei Wang, Amanda N. Fader, Kentaro Nakayama, Ryoichi Asaka, Pornpat Athamanolap, Ting-Tai Yen, Shiou-Fu Lin, Leslie M. Cope, Thomas R. Pisanic
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5160d255a0318b0dbc544e2bd916d730
https://doi.org/10.1158/1078-0432.22468454.v1
https://doi.org/10.1158/1078-0432.22468454.v1
Autor:
Tian-Li Wang, Ie-Ming Shih, Tza-Huei Wang, Amanda N. Fader, Kentaro Nakayama, Ryoichi Asaka, Pornpat Athamanolap, Ting-Tai Yen, Shiou-Fu Lin, Leslie M. Cope, Thomas R. Pisanic
Purpose:High-grade serous ovarian carcinoma (HGSOC) typically remains undiagnosed until advanced stages when peritoneal dissemination has already occurred. Here, we sought to identify HGSOC-specific alterations in DNA methylation and assess their pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077af045daceedab28448d94978e4911
https://doi.org/10.1158/1078-0432.c.6526949.v1
https://doi.org/10.1158/1078-0432.c.6526949.v1