Výsledky vyhledávání - "Leslie M. Besecke"

Nonpeptide Luteinizing Hormone-Releasing Hormone Antagonists Derived from Erythromycin A: Design, Synthesis, and Biological Activity of Cladinose Replacement Analogues

Autor: Daryl R. Sauer, Jonathan Greer, Charles J. Nichols, Craig D. Wegner, Jason A. Segreti, Kurt M. Mohning, Fortuna Haviv, John T. Randolph, E N Bush, Philip L. Waid, Gilbert Diaz, Leslie M. Besecke, Gary Bammert

Publikováno v: Journal of Medicinal Chemistry. 47:1085-1097

The design and synthesis of a series of 11,12-cyclic carbamate derivatives of 6-O-methylerythromycin A that are novel, nonpeptide LHRH antagonists, is described. The macrolide antagonist 1, discovered during a screen of our chemical repository, was c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fabef2f09ac213c5e8373f774e466e4
https://doi.org/10.1021/jm030418i

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Pharmacological and endocrine characterization of A-198401, an orally active GnRH antagonist, in intact and castrate male rat models

Autor: Kurt M. Mohning, E N Bush, Van A. Cybulski, Craig D. Wegner, Gilbert Diaz, Randolph John, Mira Rao, Jason A. Segreti, Jonathan Greer, Fortuna Haviv, Philip L. Waid, Leslie M. Besecke

Publikováno v: Drug Development Research. 52:485-491

Gonadotropin-releasing hormone (GnRH) stimulates the synthesis and secretion of the gonadotropins that maintain the reproductive axis in mammals. Efforts have focused on the characterization of novel, nonpeptidic orally active antagonists of the GnRH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34863a63a9805da58bf9feed4e71ffc9
https://doi.org/10.1002/ddr.1150

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Neuropeptide Y Y1-Receptor Stimulation Is Required for Physiological Amplification of Preovulatory Luteinizing Hormone Surges*

Autor: Sarah M. Leupen, Jon E. Levine, Leslie M. Besecke

Publikováno v: Endocrinology. 138:2735-2739

Neuropeptide Y (NPY) has been shown to potentiate the actions of LHRH during the generation of preovulatory LH surges. It is not yet known, however, if activation of a specific subtype of NPY receptors in the anterior pituitary gland is an obligatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52552036169a66903d1cd63a058ee724
https://doi.org/10.1210/endo.138.7.5223

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Gonadotropin-releasing hormone regulates follicle-stimulating hormone-beta gene expression through an activin/follistatin autocrine or paracrine loop

Autor: Jeffrey Weiss, J L Jameson, M J Guendner, Alan L. Schneyer, Leslie M. Besecke, Angela C. Bauer-Dantoin

Publikováno v: Endocrinology. 137:3667-3673

The FSH beta gene is stimulated by low frequency pulses of GnRH, but is unaffected or suppressed when GnRH is applied at higher frequencies or continuously. The current studies explored the hypothesis that GnRH frequency-dependent regulation of FSH b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d3f42268e1d5d90d1db06c3d49f3a5
https://doi.org/10.1210/endo.137.9.8756531

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Neuropeptide Y stimulates luteinizing hormone-releasing hormone release from superfused hypothalamic GT1-7 cells

Autor: Jon E. Levine, Mark Pierce, Andrew Wolfe, Joseph S. Takahashi, Leslie M. Besecke

Publikováno v: Endocrinology. 135:1621-1627

The effects of neuropeptide Y (NPY) on LHRH release from an immortalized cell line were investigated using a flow-through cell culture superfusion system. Immortalized hypothalamic GT1-7 cells were cultured for 72 h and superfused for a total of 180

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f600a77acb20dc279a720cef575b986
https://doi.org/10.1210/endo.135.4.7925125

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Differential Gonadotropin Responses to N-Methyl-D,L-aspartate in Intact and Castrated Male Rats1

Autor: Jon E. Levine, Frank J. Strobl, Andrew Wolfe, Ulrike Luderer, Neena B. Schwartz, Leslie M. Besecke

Publikováno v: Biology of Reproduction. 48:867-873

Peripheral administration of N-methyl-D,L-aspartate (NMA), a neuroexcitatory amino acid agonist, probably stimulates LH release through an increase in endogenous LHRH secretion. In the present study, NMA and a potent LHRH antagonist were used to dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6889c9f54e9e6c16afcad32ed158c308
https://doi.org/10.1095/biolreprod48.4.867

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From peptide to non-peptide: The design of LHRH antagonist mimetics

Autor: Crawford Bradley W, Craig D. Wegner, Wesley J. Dwight, Frey Lisa Marie, Fortuna Haviv, Eugene N. Bush, Rolf E. Swenson, Kurt M. Mohning, Gary Bammert, Yoshihiro Sugiura, Kaminski Michele A, Milan Bruncko, Jonathan Greer, Kaneyoshi Kato, Leslie M. Besecke, Mary Spangler, Gilbert Diaz, Jason A. Segreti

Publikováno v: Peptides for the New Millennium ISBN: 0792364457

Fortuna Haviv, Wesley Dwight, Bradley Crawford, Rolf Swenson, Milan Bruncko, Michele Kaminski, Kaneyoshi Kato, Yoshihiro Sugiura, Lisa Frey, Gilbert Diaz, Gary Bammert, Eugene N. Bush, Leslie Besecke, Kurt Mohning, Jason Segreti, Mary Spangler, Craig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbf25eab17aec1d40066ea8038c0376c
https://doi.org/10.1007/0-306-46881-6_97

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Inhibin A and inhibin B are inversely correlated to follicle-stimulating hormone, yet are discordant during the follicular phase of the rat estrous cycle, and inhibin A is expressed in a sexually dimorphic manner

Autor: Jeffrey Weiss, Neena B. Schwartz, Leslie M. Besecke, Teresa K. Woodruff, Lawrence B. Draper, Nigel Groome

Publikováno v: Endocrinology. 137(12)

Inhibin A and inhibin B are related dimeric protein hormones and endocrine regulators of the reproductive axis. Specifically, inhibin inhibits FSH secretion from the anterior pituitary. The inhibins are synthesized by the gonads and are themselves mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85a07ee30447325397ccb9299b95dba
https://pubmed.ncbi.nlm.nih.gov/8940372

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Amplitude and frequency modulation of pulsatile luteinizing hormone-releasing hormone release

Autor: Jon E. Levine, Patrick E. Chappell, Angela C. Bauer-Dantoin, Leslie M. Besecke, Andrew Wolfe, Tarja Porkka-Heiskanen, Janice H. Urban

Publikováno v: Cellular and molecular neurobiology. 15(1)

1. A variety of neuroendocrine approaches has been used to characterize cellular mechanisms governing luteinizing hormone-releasing hormone (LHRH) pulse generation. We review recent in vivo microdialysis, in vitro superfusion, and in situ hybridizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f483070062afdf9e5e2a267aec31bb
https://pubmed.ncbi.nlm.nih.gov/7648605

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Acute increase in responsiveness of luteinizing hormone (LH)-releasing hormone nerve terminals to neuropeptide-Y stimulation before the preovulatory LH surge

Autor: Jon E. Levine, Leslie M. Besecke

Publikováno v: Endocrinology. 135(1)

Neuropeptide-Y (NPY) neurons regulate LH secretion in part through facilitation of LHRH release. We tested the hypothesis that responsiveness of LHRH neurons to NPY's facilitatory actions is physiologically regulated during the estrous cycle, and spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3e1d266cb7c5b4f206d69ed499b290
https://pubmed.ncbi.nlm.nih.gov/8013392

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