Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Leslie Leiserowitz"'
Autor:
Paul Benjamin Klar, David Geoffrey Waterman, Tim Gruene, Debakshi Mullick, Yun Song, James Boris Gilchrist, C. David Owen, Wen Wen, Idan Biran, Lothar Houben, Neta Regev-Rudzki, Ron Dzikowski, Noa Marom, Lukas Palatinus, Peijun Zhang, Leslie Leiserowitz, Michael Elbaum
Publikováno v:
ACS Central Science, Vol 10, Iss 8, Pp 1504-1514 (2024)
Externí odkaz:
https://doaj.org/article/7cfeb5939f514a70ad799edbe17e0e02
Autor:
Sergey Kapishnikov, Daniel Grolimund, Gerd Schneider, Eva Pereiro, James G. McNally, Jens Als-Nielsen, Leslie Leiserowitz
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract A key drug target for malaria has been the detoxification pathway of the iron-containing molecule heme, which is the toxic byproduct of hemoglobin digestion. The cornerstone of heme detoxification is its sequestration into hemozoin crystals,
Externí odkaz:
https://doaj.org/article/0985f7d76d7140ed84de25c8f8e8ac97
Publikováno v:
Annual Review of Materials Research. 52:57-78
Cholesterol is an essential component of animal cell membranes because it influences and controls cell membrane fluidity. Cholesterol is also responsible for the most frequent lethal pathologies in developed countries because of its intimate associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d13f4a1d792ac980340ba12aa91f3709
https://doi.org/10.1146/annurev-matsci-081720-112639
https://doi.org/10.1146/annurev-matsci-081720-112639
Autor:
Meir Lahav, Leslie Leiserowitz
Publikováno v:
Helvetica Chimica Acta. 106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba937e3b25626e0aeea3a2a0d904de00
https://doi.org/10.1002/hlca.202200172
https://doi.org/10.1002/hlca.202200172
Autor:
Margarita Shepelenko, Anna Hirsch, Neta Varsano, Fabio Beghi, Lia Addadi, Leeor Kronik, Leslie Leiserowitz
Publikováno v:
Journal of the American Chemical Society. 144:5304-5314
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae297745be50ed377c8999c610b19c88
https://doi.org/10.1021/jacs.1c10563
https://doi.org/10.1021/jacs.1c10563
Autor:
Paul Benjamin Klar, David Waterman, Tim Gruene, Debakshi Mullick, Yun Song, James B. Gilchrist, C. David Owen, Wen Wen, Idan Biran, Lothar Houben, Neta Regev-Rudzki, Ron Dzikowski, Noa Marom, Lukas Palatinus, Peijun Zhang, Leslie Leiserowitz, Michael Elbaum
Detoxification of heme in Plasmodium depends on its crystallization into hemozoin. This pathway is a major target of antimalarial drugs. X-ray powder diffraction has established that the unit cell contains a cyclic hematin dimer, yet the pro-chiral n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37bcb46363d5943b2fb579a759da2601
https://doi.org/10.1101/2022.09.15.507960
https://doi.org/10.1101/2022.09.15.507960
Publikováno v:
'ChemMedChem ', vol: 16, pages: 1515-1532 (2021)
Kapishnikov, S, Hempelmann, E, Elbaum, M, Als-Nielsen, J & Leiserowitz, L 2021, ' Malaria Pigment Crystals : The Achilles ' Heel of the Malaria Parasite ', ChemMedChem . https://doi.org/10.1002/cmdc.202000895
ChemMedChem 16(10), 1515-1532 (2021). doi:10.1002/cmdc.202000895
Chemmedchem
Kapishnikov, S, Hempelmann, E, Elbaum, M, Als-Nielsen, J & Leiserowitz, L 2021, ' Malaria Pigment Crystals : The Achilles ' Heel of the Malaria Parasite ', ChemMedChem . https://doi.org/10.1002/cmdc.202000895
ChemMedChem 16(10), 1515-1532 (2021). doi:10.1002/cmdc.202000895
Chemmedchem
ChemMedChem 16(10), 1515 - 1532 (2021). doi:10.1002/cmdc.202000895
The biogenic formation of hemozoin crystals, a crucial process in heme detoxification by the malaria parasite, is reviewed as an antimalarial drug target. We first focus on the i
The biogenic formation of hemozoin crystals, a crucial process in heme detoxification by the malaria parasite, is reviewed as an antimalarial drug target. We first focus on the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feca32a1f6098ee9fed42bb0bcecd2e2
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57803
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57803
Autor:
Debakshi Mullick, Katya Rechav, Leslie Leiserowitz, Neta Regev-Rudzki, Ron Dzikowski, Michael Elbaum
Malaria is a potentially fatal infectious disease caused by the obligate intracellular parasite Plasmodium falciparum. The parasite infects human red blood cells (RBC) and derives nutrition by catabolism of hemoglobin. As amino acids are assimilated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab641b11a82026128f735f37b8fae2b
https://doi.org/10.1101/2022.05.13.491750
https://doi.org/10.1101/2022.05.13.491750
Publikováno v:
Crystal Growth & Design. 20:858-865
Calcium oxalate minerals are broadly present in nature. They form through biogenic, geogenic, and pathogenic processes that lead to different pseudopolymorphs. Being the most common solid phase in human nephrolithiasis, calcium oxalate monohydrate (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bad46fa8fffb9772a0b0e60297ec3ee9
https://doi.org/10.1021/acs.cgd.9b01245
https://doi.org/10.1021/acs.cgd.9b01245
Autor:
Lia Addadi, Leslie Leiserowitz, Leeor Kronik, Anna Hirsch, Margarita Shepelenko, Neta Varsano
We revisit the important issues of polymorphism, structure, and nucleation of cholesterol monohydrate, using first principles calculations based on dispersion-augmented density functional theory. For the lesser known monoclinic polymorph, we obtain a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc8375bb354c788432bf2e25a4c664a
https://doi.org/10.26434/chemrxiv-2021-qbw1t-v2
https://doi.org/10.26434/chemrxiv-2021-qbw1t-v2