Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Leslie L. Heckert"'
Autor:
John Gatti, Carol J Saunders, Anna Egan, Jill D. Jacobson, Julie Strickland, Emily G. Farrow, Laurel K. Willig, Leslie L. Heckert
Publikováno v:
Endocrinology. 161
Differences of sex development (DSDs) are a constellation of conditions that result in genital ambiguity or complete sex reversal. Although determining the underlying genetic variants can affect clinical management, fewer than half of undermasculiniz
Autor:
Michael D. Griswold, John R. McCarrey, Wei Yan, Marie-Claire Orgebin-Crist, William W. Wright, Erwin Goldberg, Bernard Robaire, Mitch Eddy, Leslie L. Heckert, Vassilios Papadopoulos, Jacquetta M. Trasler, Barry R. Zirkin
Publikováno v:
AndrologyREFERENCES. 8(4)
OBJECTIVE To provide an overview of the history of the North American Testis Workshop (NATW), of its relationship to the American Society of Andrology (ASA), and of the publications that resulted from the first 25 workshops. METHODS The collection of
Publikováno v:
Archiv Der Pharmazie
Two photo-crosslinking biarsenical (CrAsH-EDT2 )-modified probes were synthesized that are expected to be useful tools for tetracysteine-labeled proteins to facilitate the co-affinity purification of their DNA binding sequences and interacting protei
Vanin-1 Inactivation Antagonizes the Development of Adrenocortical Neoplasia in Sf-1 Transgenic Mice
Autor:
Abeer El Wakil, Philippe Naquet, Perle Latre de Late, Leslie L. Heckert, Marielle Jarjat, Enzo Lalli, Ronald R. de Krijger
Publikováno v:
Endocrinology. 155:2349-2354
SF-1 (NR5A1) overexpression can induce adrenocortical tumor formation in transgenic mice and is associated with more severe prognosis in patients with adrenocortical cancer. In this study we have identified Vanin-1 (Vnn1), a SF-1 target gene, as a no
Two photo-crosslinking biarsenical (CrAsH-EDT2 )-modified probes were synthesized that are expected to be useful tools for tetracysteine-labeled proteins to facilitate the co-affinity purification of their DNA binding sequences and interacting protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589e8457795d0a667576fca7b83937e0
https://europepmc.org/articles/PMC6886079/
https://europepmc.org/articles/PMC6886079/
Autor:
Daren A. Rice, Leslie L. Heckert, Kumarasamy Ravichandiran, Tatiana S. Karpova, Valentine A. Agbor, Lovella Insisienmay
Publikováno v:
Biology of Reproduction. 93
The nuclear receptor steroidogenic factor 1 (SF-1, AD4BP, NR5A1) is a key regulator of the endocrine axes and is essential for adrenal and gonad development. Partial rescue of Nr5a1−/− mice with an SF-1-expressing transgene caused a hypomorphic p
Autor:
Mark W. Murphy, Vivian J. Bardwell, Daren A. Rice, Leslie L. Heckert, Ari Melnick, Kenny Ye, David Zarkower, Katerina Hatzi, Aaron L. Sarver
Publikováno v:
Proceedings of the National Academy of Sciences. 107:13360-13365
The DM domain proteins Doublesex- and MAB-3–related transcription factors (DMRTs) are widely conserved in metazoan sex determination and sexual differentiation. One of these proteins, DMRT1, plays diverse and essential roles in development of the v
Publikováno v:
Biology of Reproduction. 81:118-125
DMRT1 is a transcription factor expressed only in Sertoli cells and undifferentiated spermatogonia of the postnatal testis, where it is required for proper cellular differentiation and fertility. To elucidate the transcriptional regulatory regions th
Autor:
Joseph S. Tash, Sedide B. Ozturk, Sudhakar Jakkaraj, Gunda I. Georg, Leslie L. Heckert, Brian S. J. Blagg, Ramappa Chakrasali, Terri Goss Kinzy, M. Kyle Hadden, S. Kendall Smith, Jennifer R. Hughes, Kaori I. Hornbaker
Publikováno v:
Biology of Reproduction. 78:1139-1152
Gamendazole was recently identified as an orally active antispermatogenic compound with antifertility effects. The cellular mechanism(s) through which these effects occur and the molecular target(s) of gamendazole action are currently unknown. Gamend
Autor:
Daren A. Rice, Valentine A. Agbor, Ning Lei, Kaori I. Hornbaker, Tatiana S. Karpova, Leslie L. Heckert
Publikováno v:
Biology of Reproduction. 77:466-475
Immunohistochemistry was used to examine GCNA1, a germ cell-specific protein, together with DMRT1 (Doublesex and Mab-3-related transcription factor-1), a transcription factor implicated in Sertoli cell and germ cell function, in order to resolve DMRT