Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Leslie K. Williams"'
Autor:
Christina Tysoe, Leslie K. Williams, Robert Keyzers, Nham T. Nguyen, Chris Tarling, Jacqueline Wicki, Ethan D. Goddard-Borger, Adeleke H. Aguda, Suzanne Perry, Leonard J. Foster, Raymond J. Andersen, Gary D. Brayer, Stephen G. Withers
Publikováno v:
ACS Central Science, Vol 2, Iss 3, Pp 154-161 (2016)
Externí odkaz:
https://doaj.org/article/ba205bf08fcc4bb4a7ca9db931de6034
Autor:
Adeleke Aguda, Leonard J. Foster, Jacqueline Wicki, Ethan D. Goddard-Borger, Gary D. Brayer, Christina Tysoe, Robert A. Keyzers, Stephen G. Withers, Leslie K. Williams, Nham T. Nguyen, Raymond J. Andersen, Suzanne Perry, Chris A. Tarling
Publikováno v:
ACS Central Science
ACS Central Science, Vol 2, Iss 3, Pp 154-161 (2016)
ACS Central Science, Vol 2, Iss 3, Pp 154-161 (2016)
Selective inhibitors of human pancreatic α-amylase (HPA) are an effective means of controlling blood sugar levels in the management of diabetes. A high-throughput screen of marine natural product extracts led to the identification of a potent (Ki =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2203587f5c05ee5fe8629b52e661e5
http://europepmc.org/articles/PMC4819454
http://europepmc.org/articles/PMC4819454
Autor:
David E. Williams, Jacqueline Wicki, Gary D. Brayer, Coleman John, Leslie K. Williams, Stephen G. Withers, Nham T. Nguyen, Raymond J. Andersen, Violet G. Yuen, Xiaohua Zhang, Sami Caner, John H. McNeill, Christina Tysoe
Publikováno v:
Nature Chemical Biology. 11:691-696
The complex plant flavonol glycoside montbretin A is a potent (Ki = 8 nM) and specific inhibitor of human pancreatic α-amylase with potential as a therapeutic for diabetes and obesity. Controlled degradation studies on montbretin A, coupled with inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae166e64668f81caf292fcc5b366489b
https://doi.org/10.1038/nchembio.1865
https://doi.org/10.1038/nchembio.1865
Publikováno v:
Journal of Medicinal Chemistry. 55:10177-10186
The increasing prevalence of diabetes has accelerated the search for new drugs derived from natural sources. To define the functional features of two such families of compounds, the flavonols and the ethyl caffeates, we have determined the high-resol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce5744fbf8912c393e09d0b866b858e
https://doi.org/10.1021/jm301273u
https://doi.org/10.1021/jm301273u
Publikováno v:
Small Business Economics. 34:391-412
This paper examines the effect of culture on national innovation and prosperity. Because culture shapes the way people think about and behave in regard to risk, opportunities, and rewards, it should influence the nature of entrepreneurial activity an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3becb1912ac21b385338e366d22e0773
https://doi.org/10.1007/s11187-008-9145-7
https://doi.org/10.1007/s11187-008-9145-7
Autor:
Chris A. Tarling, Stephen G. Withers, Chunmin Li, Ran Zhang, Raymond J. Andersen, Katherine Woods, Leslie K. Williams, AmirAli Mahpour, Gary D. Brayer
Publikováno v:
The FASEB Journal. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6184ffb12c5a46b40a0ce45699d7c17f
https://doi.org/10.1096/fasebj.24.1_supplement.681.4
https://doi.org/10.1096/fasebj.24.1_supplement.681.4
Autor:
Stephen G. Withers, Brian P. Rempel, Leslie K. Williams, Ran Zhang, Gary D. Brayer, Chunmin Li
Publikováno v:
Biochemistry. 48(45)
While covalent catalytic intermediates of retaining alpha-transglycosylases have been structurally characterized previously, no such information for a hydrolytic alpha-amylase has been obtained. This study presents a new "in situ" enzymatic elongatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b54fc230a82d60d85d984d21d5cc9b
https://pubmed.ncbi.nlm.nih.gov/19803533
https://pubmed.ncbi.nlm.nih.gov/19803533
Autor:
Leslie K. Williams, Robert Maurus, Ran Zhang, Stephen G. Withers, Jason R Fredriksen, Gary D. Brayer, Anjuman Begum
Publikováno v:
Biochemistry. 47(11)
A mechanistic study of the essential allosteric activation of human pancreatic alpha-amylase by chloride ion has been conducted by exploring a wide range of anion substitutions through kinetic and structural experiments. Surprisingly, kinetic studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6dc87269d5d8905b4bd9e4828ef308
https://pubmed.ncbi.nlm.nih.gov/18284212
https://pubmed.ncbi.nlm.nih.gov/18284212