Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Leslie J. Lorenz"'
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 22:1009-1025
A new procedure for the amino acid analysis of peptides has been devised utilizing high performance liquid chromatography (HPLC) with evaporative light scattering detection (ELSD). This procedure eliminates the need for complex derivatization schemes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82c9e8a1d48eb73b88dd7eb0135eab09
https://doi.org/10.1081/jlc-100101714
https://doi.org/10.1081/jlc-100101714
Autor:
Monte W. Collins, Douglas E. Dorman, Gregory A. Stephenson, Larry A. Spangle, Leslie J. Lorenz, John L. Occolowitz, Steven W. Baertschi
Publikováno v:
Journal of Pharmaceutical Sciences. 86:526-539
The aqueous acidic degradation of the oral cephalosporin cefaclor was investigated. A number of degradation products were isolated and characterized. The degradation products can be loosely classified into three categories: thiazole derivatives, pyra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1fed4d0e26accb3768e9876de73dc4
https://doi.org/10.1021/js960427x
https://doi.org/10.1021/js960427x
Isolation and Structure Elucidation of the Major Degradation Products of Cefaclor in the Solid State
Autor:
Monte W. Collins, Larry A. Spangle, Fadia Najjar Bashore, John L. Occolowitz, Steven W. Baertschi, Douglas E. Dorman, Leslie J. Lorenz
Publikováno v:
Journal of Pharmaceutical Sciences. 86:540-549
Cefaclor is a beta-lactam antibiotic that degrades slowly under normal storage conditions to several minor products. To obtain samples large enough to permit structure elucidation, cefaclor was allowed to degrade at 40 degrees C (75% relative humidit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e02564b7590098ddc2c4e778b0b2e8a
https://doi.org/10.1021/js960428p
https://doi.org/10.1021/js960428p
Autor:
Michael J. Skibic, Leslie J. Lorenz, John L. Occolowitz, Steven W. Baertschi, Douglas E. Dorman, K. Wayne Taylor, Larry A. Spangle, John W. Paschal, Monte W. Collins
Publikováno v:
Journal of Pharmaceutical Sciences. 82:1010-1017
The aqueous degradation of the carbacephalosporin loracarbef under moderately acidic conditions (pH range, 2.7-4.3) is described. Structures of a total of 10 compounds isolated by preparative reversed-phase HPLC have been proposed. Five of these 10 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1db3a6848a966ab421227a927f41c27
https://doi.org/10.1002/jps.2600821002
https://doi.org/10.1002/jps.2600821002
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 13(3)
Recently an unknown degradation product of loracarbef (structure 1) was observed at low levels (--0.1%) in samples of the bulk drug substance that had been stored at 30°C for 36 months. Identification of this unknown was desired because of the poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faafa487b75c0e6e4fc791a8740d3a58
https://pubmed.ncbi.nlm.nih.gov/7619894
https://pubmed.ncbi.nlm.nih.gov/7619894
Autor:
Leslie J. Lorenz, John L. Occolowitz, Steven W. Baertschi, Marvin Emanuel Wildfeuer, Monte W. Collins, Douglas E. Dorman, Larry A. Spangle
Publikováno v:
Journal of pharmaceutical sciences. 82(6)
The acidic aqueous degradation of cefaclor, an orally administered cephalosporin antibiotic, has been investigated. The most prominent peak in the high-performance liquid chromatography profile of a degraded solution of cefaclor was isolated by prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de41fae3556b6c3e507dcd352417846e
https://pubmed.ncbi.nlm.nih.gov/8331538
https://pubmed.ncbi.nlm.nih.gov/8331538
Publikováno v:
Analytical Chemistry. 42:979-983
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fd73862fbc102a21792a0add69a94bf
https://doi.org/10.1021/ac60291a026
https://doi.org/10.1021/ac60291a026
