Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Leslie J. Holsinger"'
Autor:
Shirin Arastu‐Kapur, Mai Nguyen, Debasish Raha, Florian Ermini, Ursula Haditsch, Joseph Araujo, Ines A. M. De Lannoy, Mark I. Ryder, Stephen S. Dominy, Casey Lynch, Leslie J. Holsinger
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Abstract COR388, a small‐molecule lysine‐gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease. Gingipains are produced by two species of
Externí odkaz:
https://doaj.org/article/2e5935de51ed4fe1964b902269445d9f
Autor:
Sean Broce, Florian Ermini, Leslie J. Holsinger, Stephen S. Dominy, Michael J. Detke, Leo Rodriguez, Ursula Haditsch, Casey C. Lynch, D. David Hennings, Mai Nguyen, Jianhong Wang, Shirin Arastu-Kapur, Debasish Raha
Publikováno v:
SSRN Electronic Journal.
Gingipains are protease virulence factors from the periodontal bacterial pathogen Porphyromonas gingivalis and were recently identified in greater than 90% of Alzheimer’s disease (AD) brains. Studies in wild-type mice and rats have demonstrated tha
Autor:
Mai Nguyen, Leo Rodriguez, Florian Ermini, Sean Broce, Mike Detke, Ursula Haditsch, Steve Dominy, Debasish Raha, Sandy Hancock, Leslie J. Holsinger, Casey C. Lynch, Thomas E. Cecere, Theresa Roth, Shirin Kapur
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Debasish Raha, Steve Dominy, Ursula Haditsch, Shirin Kapur, Casey C. Lynch, Sean Broce, Theresa Roth, Leo Rodriguez, Dave Hennings, Florian Ermini, Mike Detke, Mai Nguyen, Leslie J. Holsinger
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Florian Ermini, Debasish Raha, Mai Nguyen, Leslie J. Holsinger, Casey C. Lynch, Mark I. Ryder, Stephen S. Dominy, Ines A. M. De Lannoy, Ursula Haditsch, Joseph Araujo, Shirin Arastu-Kapur
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology research & perspectives, vol 8, iss 1
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Pharmacology research & perspectives, vol 8, iss 1
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
COR388, a small‐molecule lysine‐gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease. Gingipains are produced by two species of bacteria,
Autor:
Florian Ermini, Samer Kaba, Jan Potempa, Christina Griffin, Stephen S. Dominy, Malgorzata Benedyk, Debasish Raha, Agata Marczyk, Glenn D Walker, Casey C. Lynch, Mai Nguyen, Piotr Mydel, Annelie Hellvard, Eric C. Reynolds, Hatice Hasturk, Ursula Haditsch, Andrei Konradi, Maurice A. Curtis, Richard L.M. Faull, Leslie J. Holsinger, Mark I. Ryder, Karina Adamowicz, Mike Dragunow, Barbara Potempa, Shirin Arastu-Kapur, Alexander Lee
Publikováno v:
Science advances, vol 5, iss 1
Science Advances
Science Advances
Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors.
Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s dise
Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883a50af9b4a731c268d542b0ea8cca6
https://ruj.uj.edu.pl/xmlui/handle/item/80007
https://ruj.uj.edu.pl/xmlui/handle/item/80007
Autor:
Ira J. Goodman, Mark I. Ryder, Stephen G. Thein, Ursula Haditsch, Mike Detke, Dave Hennings, Leslie J. Holsinger, Shirin Kapur, Steve Dominy, Casey C. Lynch, Florian Ermini, Debasish Raha
Publikováno v:
Alzheimer's & Dementia. 15:P1585-P1585
Publikováno v:
Genes to Cells. 15:711-724
Two isoforms of the transmembrane protein tyrosine phosphatase PTPα, which differ by nine amino acids in their extracellular regions, are expressed in a tissue-specific manner. Over-expression of the shorter isoform transforms rodent cells, and it h
Publikováno v:
The EMBO Journal. 16:5618-5628
Signaling by the antigen receptor of T lymphocytes initiates different developmental transitions, each of which require the tyrosine kinase ZAP70. Previous studies with agonist and antagonist peptides have indicated that ZAP70 might respond different
Autor:
Franck Rapaport, Johanna A. Joyce, Lisa Sevenich, William C. Hahn, Benelita T. Elie, Robert L. Bowman, Steven D. Mason, Christina S. Leslie, Edi Brogi, Joan Massagué, Priscilla K. Brastianos, Daniela F. Quail, Leslie J. Holsinger
Publikováno v:
Nature cell biology
Metastasis remains the most common cause of death in most cancers, with limited therapies for combating disseminated disease. While the primary tumour microenvironment is an important regulator of cancer progression, it is less well understood how di