Výsledky vyhledávání - "Leslie J. Browne"

Chemogenomics – pharmacology with genomics tools

Autor: Kurt Jarnagin, George Natsoulis, Cecelia Pearson, Leslie J. Browne, L. Mike Furness

Publikováno v: TARGETS. 1:59-65

Although genomics tools and approaches abound, and many new genes and proteins have been identified, genomics has not contributed very effectively to improving the efficiencies and success rates in the drug discovery process. However, chemogenomics,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67fda35c90bf3e20fa36daa9be0abd3b
https://doi.org/10.1016/s1477-3627(02)02245-6

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Novel aromatase inhibitors

Autor: Steele Ronald Edward, Ajay S. Bhatnagar, Klaus Schieweck, Leslie J. Browne, Bowman Robert M, A. Häusler

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 37:363-367

Aminoglutethimide (AG), an inhibitor of the aromatase enzyme, inhibits the biosynthesis of estrogens and displays well-documented anti-tumor efficacy in breast-cancer. However, this efficacy is accompanied by a relative lack of specificity in inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe512d2a20fd216088d2a2fe8c59dceb
https://doi.org/10.1016/0960-0760(90)90485-4

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Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action

Publikováno v: Journal of biotechnology. 119(3)

Successful drug discovery requires accurate decision making in order to advance the best candidates from initial lead identification to final approval. Chemogenomics, the use of genomic tools in pharmacology and toxicology, offers a promising enhance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a92d42878471e7309a9e3586580030
https://pubmed.ncbi.nlm.nih.gov/16005536

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Mature Results of a Phase 1-2 Open-Label, Dose-Escalation Study of Intravenous SNS01-T in Patients (pts) with Relapsed or Refractory B-Cell Malignancies

Autor: John E. Thompson, William I. Bensinger, Michael Craig, David S. Siegel, Edward N. Libby, Leslie J. Browne, Frits van Rhee, Michael R. Kurman, Catherine A. Taylor, Andrew M. McDonald, Nicolas Novitzky, Richard Dondero, John A. Lust, Martin Gutierrez, Alice Bexon, Charles Barranco

Publikováno v: Blood. 124:4464-4464

Background Eukaryotic translation initiation factor 5A (eIF5A) has been implicated in the regulation of cell proliferation, apoptosis, and inflammation. SNS01-T is a novel therapeutic with a dual mechanism of eIF5A modulation: inducing cell death via

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be7d59403116401c314bc60be210eeeb
https://doi.org/10.1182/blood.v124.21.4464.4464

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Phase 1-2 open-label, multiple-dose, dose-escalation study to evaluate the safety and tolerability of intravenous infusion of SNS01-T, a first-in-class modulator of eukaryotic translation initiation factor 5A (eIF5A) in patients (pts) with relapsed or refractory B-cell malignancies

Autor: Alice Bexon, John E. Thompson, Catherine A. Taylor, Michael R. Kurman, David S. Siegel, Richard Dondero, Michael Craig, Charles Barranco, John A. Lust, Martin Gutierrez, Nicolas Novitzky, William I. Bensinger, Leslie J. Browne, Andrew M. McDonald, Edward N. Libby, Frits van Rhee

Publikováno v: Journal of Clinical Oncology. 32:TPS8616-TPS8616

TPS8616 Background: eIF5A has been implicated in the regulation of cell proliferation, apoptosis, and inflammation. It is the only known protein to be modified by hypusination, and is highly conser...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d593a789c22c9e3e06f386b08eaba39
https://doi.org/10.1200/jco.2014.32.15_suppl.tps8616

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Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 97(4)

Potent and selective inhibitors of inducible nitric oxide synthase (iNOS) (EC 1.14.13.39 ) were identified in an encoded combinatorial chemical library that blocked human iNOS dimerization, and thereby NO production. In a cell-based iNOS assay (A-172

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8792d464785ae85fa380e5ae1614e67d
https://pubmed.ncbi.nlm.nih.gov/10677491

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Phase 1b/2a Open-Label, Multiple-Dose, Dose-Escalation Study To Evaluate The Safety and Tolerability Of Intravenous Infusion Of SNS01-T In Patients With Relapsed Or Refractory Multiple Myeloma, Mantle Cell Lymphoma, Or Diffuse Large B Cell Lymphoma

Autor: John A Lust, Charles Barranco, Saad Z Usmani, Frits van Rhee, Mehdi Hamadani, John Thompson, Catherine A Taylor, Richard Dondero, Leslie J. Browne, David Siegel, William I. Bensinger

Publikováno v: Blood. 122:1950-1950

Eukaryotic translation initiation factor 5A (eIF5A) has been implicated in the regulation of cell proliferation, apoptosis, and inflammation, and is the only known protein to be modified by hypusination. Hypusinated eIF5A, the predominant form of eIF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4986a3b37860c8174219b93ad2df204
https://doi.org/10.1182/blood.v122.21.1950.1950

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Chapter 1. New Anxiolytics

Autor: Leslie J. Browne, Kenneth J. Shaw

Publisher Summary While the disease state of anxiety is not yet fully understood, the structure elucidation of the macromolecular complex consisting of chloride channel, barbiturate receptor, gamma-aminobutyric acid (GABA) receptor, and benzodiazepin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13e5cf001c7a7d66ae0585a058d42d80
https://doi.org/10.1016/s0065-7743(08)61188-4

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