Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Leslie J. Berg"'
Autor:
Julianne B. Riggs, Eva M. Medina, Loni J. Perrenoud, Diana L. Bonilla, Eric T. Clambey, Linda F. van Dyk, Leslie J. Berg
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Investigating the dynamics of virus-host interactions in vivo remains an important challenge, often limited by the ability to directly identify virally infected cells. Here, we utilize a beta-lactamase activated fluorescent substrate to identify prim
Externí odkaz:
https://doaj.org/article/a5d65b88875f488e82aa0fae07cd233b
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Signals mediating tissue-specific control of immune cell fate and function remain largely uncharacterized. Here the authors uncover a requirement of ITK, a kinase mediating TCR signaling, for IL-2-dependent ILC2 cell survival specifically in the inte
Externí odkaz:
https://doaj.org/article/1d4279bb99b54c9a90b4d5b38b6101b5
Autor:
Catherine S. Forconi, David H. Mulama, Priya Saikumar Lakshmi, Joslyn Foley, Juliana A. Otieno, Jonathan D. Kurtis, Leslie J. Berg, John M. Ong’echa, Christian Münz, Ann M. Moormann
Publikováno v:
Cancers, Vol 13, Iss 21, p 5375 (2021)
Children diagnosed with endemic Burkitt lymphoma (eBL) are deficient in interferon-γ (IFN-γ) responses to Epstein–Barr Nuclear Antigen1 (EBNA1), the viral protein that defines the latency I pattern in this B cell tumor. However, the contributions
Externí odkaz:
https://doaj.org/article/bb122935afb24a43bdd53e3e655ec679
Autor:
Tuoqi Wu, Hyun Mu Shin, E. Ashley Moseman, Yun Ji, Bonnie Huang, Christelle Harly, Jyoti M. Sen, Leslie J. Berg, Luca Gattinoni, Dorian B. McGavern, Pamela L. Schwartzberg
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 2099-2110 (2015)
T follicular helper (TFH) and T helper 1 (Th1) cells generated after viral infections are critical for the control of infection and the development of immunological memory. However, the mechanisms that govern the differentiation and maintenance of th
Externí odkaz:
https://doaj.org/article/3c3cfee35705436eae052daf1f1a1415
Autor:
Lisa M. Spain, Leslie J. Berg
Publikováno v:
Clinical and Developmental Immunology, Vol 4, Iss 1, Pp 43-53 (1994)
Externí odkaz:
https://doaj.org/article/76bec55dd65e496f8b2db54a6edd82ab
Publikováno v:
Journal of visualized experiments : JoVE. (190)
Calcium influx in response to T-cell receptor stimulation is a common measure of T-cell signaling. Several calcium indicator dyes have been developed to assess calcium signaling by band-pass flow cytometry. This protocol is designed to measure calciu
Publikováno v:
J Immunol
TCR signal strength is critical for CD8+ T cell clonal expansion after Ag stimulation. Levels of the transcription factor IRF4 control the magnitude of this process through the induction of genes involved in proliferation and glycolytic metabolism. T
Autor:
Jun R. Huh, Edward J. Usherwood, Hyun Mu Shin, Jason A. Hall, Leslie J. Berg, Andrea Reboldi, Soyoung Ha, Hyoung-Soo Cho
Publikováno v:
ImmunoHorizons. 4:57-71
The Tec kinase IL-2–inducible T cell kinase (ITK) regulates the expression of TCR-induced genes. Itk−/− T cell responses are impaired but not absent. ITK inhibition prevented colitis disease progression and impaired T cell migration to the colo
Autor:
Juliana A. Otieno, Priya Saikumar Lakshmi, John M. Ong’echa, Christian Münz, David H. Mulama, Leslie J. Berg, Ann Moormann, Jonathan D. Kurtis, Catherine S. Forconi, Joslyn Foley
Publikováno v:
Cancers
Volume 13
Issue 21
Cancers, Vol 13, Iss 5375, p 5375 (2021)
Volume 13
Issue 21
Cancers, Vol 13, Iss 5375, p 5375 (2021)
Children diagnosed with endemic Burkitt lymphoma (eBL) are deficient in interferon-γ (IFN-γ) responses to Epstein–Barr Nuclear Antigen1 (EBNA1), the viral protein that defines the latency I pattern in this B cell tumor. However, the contributions
Autor:
Manuel Garber, Andrea Reboldi, Leslie J Berg, Michael P. Gallagher, Pranitha Vangala, James M Conley
Publikováno v:
Proc Natl Acad Sci U S A
The strength of peptide:MHC interactions with the T cell receptor (TCR) is correlated with the time to first cell division, the relative scale of the effector cell response, and the graded expression of activation-associated proteins like IRF4. To re