Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Leslie J. Askonas"'
Autor:
Walter G. Smith, Suzanne H Kim, Doreen Villani-Price, Matthew W Mahoney, Nayereh S Ghoreishi-Haack, Helen Y. Chen, Thomas D. Penning, Stella Siu-Tzyy Yu, James W. Malecha, Leslie J Askonas, Chi-Dean Liang, Elizabeth I Harding, E.Yvonne Pyla, Maureen K Highkin, James K. Gierse, Julie M Miyashiro, Mark A Russell, James F Kachur, Chen Barbara B
Publikováno v:
Journal of Medicinal Chemistry. 45:3482-3490
Leukotriene B(4) (LTB(4)) is a potent, proinflammatory mediator involved in the pathogenesis of a number of diseases including inflammatory bowel disease, psoriasis, rheumatoid arthritis, and asthma. The enzyme LTA(4) hydrolase represents an attracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49aaaeb42023ad7fd78de02ecc724a97
https://doi.org/10.1021/jm0200916
https://doi.org/10.1021/jm0200916
Autor:
Leslie J Askonas, Mark A Russell, Walter G. Smith, James F. Kachur, Chi-Dean D. Liang, D Villani-Price
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 300:577-582
Leukotriene (LT) A(4) hydrolase is a dual function enzyme that is essential for the conversion of LTA(4) to LTB(4) and also possesses an aminopeptidase activity. SC-57461A (3-[methyl[3-[4-phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl) is a pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a43488c1feb896fd592f6e43e83a9e0
https://doi.org/10.1124/jpet.300.2.577
https://doi.org/10.1124/jpet.300.2.577
Autor:
Thomas D. Penning, Nizal S. Chandrakumar, Barbara B. Chen, Helen Y. Chen, Bipin N. Desai, Stevan W. Djuric, Stephen H. Docter, Alan F. Gasiecki, Richard A. Haack, Julie M. Miyashiro, Mark A. Russell, Stella S. Yu, David G. Corley, Richard C. Durley, Brian F. Kilpatrick, Barry L. Parnas, Leslie J. Askonas, James K. Gierse, Elizabeth I. Harding, Maureen K. Highkin, James F. Kachur, Suzanne H. Kim, Gwen G. Krivi, Doreen Villani-Price, E. Yvonne Pyla, Walter G. Smith, Nayereh S. Ghoreishi-Haack
Publikováno v:
Journal of Medicinal Chemistry. 43:721-735
Leukotriene B(4) (LTB(4)) is a pro-inflammatory mediator that has been implicated in the pathogenesis of a number of diseases including inflammatory bowel disease (IBD) and psoriasis. Since the action of LTA(4) hydrolase is the rate-limiting step for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2c8b8f857645ec82bda0e73ed60429
https://doi.org/10.1021/jm990496z
https://doi.org/10.1021/jm990496z
Autor:
Gwen Grabowski Krivi, E.Yvonne Pyla, Stevan W. Djuric, Thomas D. Penning, Richard A. Haack, Leslie J Askonas, Stella S. Yu, Marshall L. Michener
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2517-2522
The hydroxamic acid-containing peptide kelatorphan, a known inhibitor of enkephalin-degrading enzymes, is a potent, non-competitive inhibitor of leukotriene A4 (LTA4) hydrolase. Analogs of kelatorphan were prepared and several significantly and selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3a3f3d9ad1c6b8bb68f2906bec02974
https://doi.org/10.1016/0960-894x(95)00441-u
https://doi.org/10.1016/0960-894x(95)00441-u
Autor:
Doreen Villani-Price, Suzanne H Kim, Walter G. Smith, Leslie J Askonas, Elizabeth I Harding, Maureen K Highkin, Thomas D. Penning, Alan F. Gasiecki, Nayereh S Ghoreishi-Haack, Nizal S Chandrakumar, E.Yvonne Pyla, Bipin N Desai, James F Kachur, Mark A Russell, Stevan W Djuric, James W. Malecha, James K. Gierse, Julie M Miyashiro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1137-1139
The synthesis and biological evaluation of a series of heterocyclic analogues of the previously reported LTA(4) hydrolase inhibitor 1b are described. Imidazopyridine and purine analogues are specifically highlighted with several demonstrating excelle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6830ee52b64cb2d30d9d134d0185d9a9
https://doi.org/10.1016/s0960-894x(03)00039-8
https://doi.org/10.1016/s0960-894x(03)00039-8
Autor:
Trevor M. Penning, Leslie J. Askonas
Publikováno v:
Biochemistry. 30:11553-11560
Nonsteroidal anti-inflammatory drugs (NSAIDs) exert their effect by inhibiting the target enzyme cyclooxygenase (prostaglandin H2 synthase); however, little is known about the peptides comprising its NSAID binding site. Hydroxyprostaglandin dehydroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5e5e0c3724814dce5c31503c99e20e
https://doi.org/10.1021/bi00113a010
https://doi.org/10.1021/bi00113a010
Publikováno v:
Biochemistry. 30:9988-9997
The acetylenic analogue of adenosine 9-(5',6'-dideoxy-beta-D-ribo-hex-5'-ynofuranosyl)adenine has been synthesized, and its behavior as an inhibitor of bovine S-adenosylhomocysteine hydrolase has been examined. Incubation of the enzyme with excess in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43605b1b6fa49cc0865baa032b4c3a40
https://doi.org/10.1021/bi00105a025
https://doi.org/10.1021/bi00105a025
Autor:
Maureen K Highkin, Leslie J Askonas, Doreen Villani-Price, Chi-Dean Liang, Bipin N Desai, Thomas D. Penning, James F Kachur, Elizabeth I Harding, Nayereh S Ghoreishi-Haack, Mark A Russell, Julie M Miyashiro, Walter G. Smith, E.Yvonne Pyla, Nizal S Chandrakumar, Stevan W Djuric, Suzanne H Kim, James K. Gierse, Alan F. Gasiecki
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(23)
The synthesis and biological evaluation of a series of functionalized pyrrolidine- and piperidine-containing analogues of our lead LTA(4) hydrolase inhibitor, SC-57461A, is described. A number of compounds showed excellent potency in our in vitro scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bec3c88d96d40830db918a67cb8307f
https://pubmed.ncbi.nlm.nih.gov/12419366
https://pubmed.ncbi.nlm.nih.gov/12419366
Autor:
James F. Kachur, Leslie J. Askonas, Doreen Villani-Price, Nayereh Ghoreishi-Haack, Suzanne Won-Kim, Chi-Dean D. Liang, Mark A. Russell, Walter G. Smith
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 300(2)
Leukotriene (LT) A(4) hydrolase is a dual function enzyme that is essential for the conversion of LTA(4) to LTB(4) and also possesses an aminopeptidase activity. SC-57461A (3-[methyl[3-[4-phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl) is a pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dd328be3aae29c01487cfa97414149
https://pubmed.ncbi.nlm.nih.gov/11805220
https://pubmed.ncbi.nlm.nih.gov/11805220
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461374305
Prostaglandin H2 (PGH) synthase (EC 1.14.99.1) catalyzes the bis-dioxygenation of arachidonic acid to yield PGG2 (cyclooxygenase reaction) and the peroxidative cleavage of PGG2 to yield PGH2 (peroxidase reaction). PGH synthase (Mr: 72 kDa) functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3025944b235a1e636e6155d7cfc9da6e
https://doi.org/10.1007/978-1-4615-5325-0_11
https://doi.org/10.1007/978-1-4615-5325-0_11
