Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Leslie Ingram-Drake"'
Autor:
Margarete Mehrabian, Leslie Ingram-Drake, Haijin Meng, Susanna S. Wang, Martina Neboháčová, Xuping Wang, Aldons J. Lusis, Thomas A. Drake, Eric E. Schadt, Wei Zhao, Lisa J. Martin
Publikováno v:
Circulation: Cardiovascular Genetics. 2:573-582
Background— Disruption of the elastic lamina, as an early indicator of aneurysm formation, and vascular calcification frequently occur together in atherosclerotic lesions of humans. Methods and Results— We now report evidence of shared genetic ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6179effda6e8f3064edf982e7c65e572
https://doi.org/10.1161/circgenetics.109.860270
https://doi.org/10.1161/circgenetics.109.860270
Autor:
Leslie Ingram-Drake, Nam Che, Anatole Ghazalpour, Susanna Wang, Matteo Pellegrini, Atila van Nas, Jesus A. Araujo, Aldons J. Lusis, Shawn J. Cokus, Luz D. Orozco
Publikováno v:
Human Molecular Genetics. 18:4118-4129
Copy number variants (CNVs) are genomic segments which are duplicated or deleted among different individuals. CNVs have been implicated in both Mendelian and complex traits, including immune and behavioral disorders, but the study of the mechanisms b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc66c9d8b99d2d79b56930d62b1f460
https://doi.org/10.1093/hmg/ddp360
https://doi.org/10.1093/hmg/ddp360
Autor:
Steve Horvath, Leslie Ingram-Drake, Gautam Chaudhuri, Atila van Nas, Thomas A. Drake, Nadir Yehya, Eric E. Schadt, Susanna S. Wang, Aldons J. Lusis, Arthur P. Arnold, Debraj GuhaThakurta, Bin Zhang
Publikováno v:
Endocrinology. 150:1235-1249
We previously used high-density expression arrays to interrogate a genetic cross between strains C3H/HeJ and C57BL/6J and observed thousands of differences in gene expression between sexes. We now report analyses of the molecular basis of these sex d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc28f7f6e6071cf7fb9ad44497dd12a
https://doi.org/10.1210/en.2008-0563
https://doi.org/10.1210/en.2008-0563
Autor:
Dorothy S. Martinez, Leslie Ingram-Drake, Archana R. Sadhu, Willa A. Hsueh, Alfonso Ang, Susan L. Ettner
Publikováno v:
Diabetes Care
OBJECTIVE—The purpose of this study was to analyze the economic outcomes of a clinical program implemented to achieve strict glycemic control with intensive insulin therapy in patients admitted to the intensive care unit (ICU). RESEARCH DESIGN AND
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e402d3b36854a018a2333dceff2ea9fa
http://europepmc.org/articles/PMC2494645
http://europepmc.org/articles/PMC2494645
Autor:
Aldons J. Lusis, Xia Yang, Hui Wang, Arthur P. Arnold, Thomas A. Drake, Eric E. Schadt, Leslie Ingram-Drake, Susanna Wang
Publikováno v:
Genome Research. 16:995-1004
We report a comprehensive analysis of gene expression differences between sexes in multiple somatic tissues of 334 mice derived from an intercross between inbred mouse strains C57BL/6J and C3H/HeJ. The analysis of a large number of individuals provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073c82d0e4b2ebe5219d14e0f9bcb635
https://doi.org/10.1101/gr.5217506
https://doi.org/10.1101/gr.5217506
Autor:
Chris Rhee, Paul Krogstad, Leslie Ingram-Drake, Martin G. Martin, Lirona Katzir, Ricardo A. Molina, Theodore B. Moore
Publikováno v:
American Journal of Transplantation. 4:1656-1661
In children, aplastic anemia (AA) is a common complication associated with fulminant hepatic failure (FHF). The objective of this study was to determine whether specific pretransplantation clinical and laboratory characteristics can be used to distin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7db84ba73791d16322559dc31a5687
https://doi.org/10.1111/j.1600-6143.2004.00559.x
https://doi.org/10.1111/j.1600-6143.2004.00559.x
Autor:
Leslie Ingram-Drake, Susanna S. Wang, Thomas A. Drake, Eric E. Schadt, Atila van Nas, Janet S. Sinsheimer, Aldons J. Lusis
Publikováno v:
Genetics. 185(3)
By treating the transcript abundance as a quantitative trait, gene expression can be mapped to local or distant genomic regions relative to the gene encoding the transcript. Local expression quantitative trait loci (eQTL) generally act in cis (that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3953c19ab8082e59e7c6d9ca38159a30
https://pubmed.ncbi.nlm.nih.gov/20439777
https://pubmed.ncbi.nlm.nih.gov/20439777
Autor:
Roumyana Yordanova, Leslie Ingram-Drake, Aiqing He, Casey E. Romanoski, Christopher L. Plaisier, Bo Guan, Michelle J. Kim, Todd G. Kirchgessner, Peter S. Gargalovic, Charles Tilford, Sangderk Lee, Judith A. Berliner, Aldons J. Lusis
Publikováno v:
American journal of human genetics. 86(3)
Gene by environment (GxE) interactions are clearly important in many human diseases, but they have proven to be difficult to study on a molecular level. We report genetic analysis of thousands of transcript abundance traits in human primary endotheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd1e9cd8eec4948d9845046b02b551e
https://pubmed.ncbi.nlm.nih.gov/20170901
https://pubmed.ncbi.nlm.nih.gov/20170901
Autor:
Weibin Shi, Leslie Ingram-Drake, Aldons J. Lusis, Hui Wang, Thomas A. Drake, Eric E. Schadt, Susanna S. Wang, Xuping Wang
Publikováno v:
Circulation Research. 101
We report a combined genetic and genomic analysis of atherosclerosis in a cross between the strains C3H/HeJ and C57BL/6J on a hyperlipidemic apolipoprotein E–null background. We incorporated sex and sex-by-genotype interactions into our model selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d503644026f6779ea6d9dd098f5b4b86
https://doi.org/10.1161/circresaha.107.152975
https://doi.org/10.1161/circresaha.107.152975
Autor:
Iset Medina Vera, Susanna S. Wang, Thomas A. Drake, Aldons J. Lusis, Eric E. Schadt, Leslie Ingram-Drake, Haijin Meng, Nam Che, Xuping Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(11)
The genetic factors contributing to the complex disorder of myocardial calcification are largely unknown. Using a mouse model, we fine-mapped the major locus ( Dyscalc1 ) contributing to the dystrophic cardiac calcification (DCC) to an 840-kb interva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9245da1447ea1eaa041a82a1a318f874
https://pubmed.ncbi.nlm.nih.gov/17360558
https://pubmed.ncbi.nlm.nih.gov/17360558