The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide

Autor: Unnati M. Pandya, Chinaza Egbuta, Trefa M. Abdullah Norman, Chih-Yuan (Edward) Chiang, Valerie R. Wiersma, Rekha G. Panchal, Edwin Bremer, Paul Eggleton, Leslie I Gold

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 2, p 408 (2019)

The endoplasmic reticulum (ER) chaperone protein, calreticulin (CRT), is essential for proper glycoprotein folding and maintaining cellular calcium homeostasis. During ER stress, CRT is overexpressed as part of the unfolded protein response (UPR). In

Externí odkaz: https://doaj.org/article/ea26aac3bf024ba5b3e4c9e177b8e6b1

Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer.

Autor: Kuang-Tzu Huang, Savvas C Pavlides, Jon Lecanda, Stephanie V Blank, Khushbakhat R Mittal, Leslie I Gold

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e46072 (2012)

The levels of proteins that control the cell cycle are regulated by ubiquitin-mediated degradation via the ubiquitin-proteasome system (UPS) by substrate-specific E3 ubiquitin ligases. The cyclin-dependent kinase inhibitor, p27kip1 (p27), that blocks

Externí odkaz: https://doaj.org/article/fe82353b2459470f87c798dd7d5fd2b8

Heightened autoantibody immune response to citrullinated calreticulin in bronchiectasis: Implications for rheumatoid arthritis

Autor: Leslie I. Gold, William E R Ollier, Alex Clarke, Elizabeth Perry, David Hutchinson, Kate J. Heesom, Anthony De Soyza, Paul Eggleton, Clive Kelly

Publikováno v: The international journal of biochemistrycell biology. 89

Calreticulin (CRT) and citrullinated (citCRT) are implicated in rheumatoid arthritis (RA) pathology. citCRT binds to RA shared epitopes (SE) on HLA-DR molecules with high affinity and triggers pro-inflammatory events in adjacent cells. The aim of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5ffae965d5f756cedaa02b7c245e9b
https://pubmed.ncbi.nlm.nih.gov/28652209

The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide

Autor: Chinaza Egbuta, Paul Eggleton, Valerie R. Wiersma, Trefa M Abdullah Norman, Edwin Bremer, Chih-Yuan Edward Chiang, Rekha G. Panchal, Unnati M. Pandya, Leslie I. Gold

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 2, p 408 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 2
International Journal of Molecular Sciences, 20(2):408. MDPI AG

The endoplasmic reticulum (ER) chaperone protein, calreticulin (CRT), is essential for proper glycoprotein folding and maintaining cellular calcium homeostasis. During ER stress, CRT is overexpressed as part of the unfolded protein response (UPR). In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a906d03a8546c5b7aeeb37d972b6184
https://doi.org/10.3390/ijms20020408

Exogenous calreticulin improves diabetic wound healing

Autor: Savvas C. Pavlides, Fares Samra, Caprice Cadacio, Keith M. Blechman, Matthew R. Greives, Tara A. Bancroft, Leslie I. Gold, Christopher D. Woodrell, Jamie P. Levine, Marek Michalak, Stephen M. Warren, Sara Megumi Naylor

Publikováno v: Wound Repair and Regeneration. 20:715-730

A serious consequence of diabetes mellitus is impaired wound healing, which largely resists treatment. We previously reported that topical application of calreticulin (CRT), an endoplasmic reticulum chaperone protein, markedly enhanced the rate and q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39dbd8c811c5e33010a44ef9c25292e3
https://doi.org/10.1111/j.1524-475x.2012.00822.x