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of 7
pro vyhledávání: '"Leslie Holsinger"'
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice
Autor:
Ryan Brown, Donna M. Small, Declan F. Doherty, Leslie Holsinger, Robert Booth, Richard Williams, Rebecca J. Ingram, J. Stuart Elborn, Marcus A. Mall, Clifford C. Taggart, Sinéad Weldon
Publikováno v:
Mediators of Inflammation, Vol 2021 (2021)
Background. Elevated levels of the cysteine protease cathepsin S (CatS) are associated with chronic mucoobstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). We have previously demonstrated that prop
Externí odkaz:
https://doaj.org/article/7f801294803e401ab88bd8dd4b1176eb
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice
Autor:
Rebecca J. Ingram, Leslie Holsinger, Donna M. Small, Richard Williams, Robert Booth, Marcus A. Mall, Declan Doherty, Clifford C. Taggart, Ryan Brown, Sinéad Weldon, J. Stuart Elborn
Publikováno v:
Mediators of Inflammation, Vol 2021 (2021)
Brown, R, Small, D, Doherty, D F, Holsinger, L, Booth, R, Williams, R, Ingram, R J, Elborn, J S, Mall, M A, Taggart, C C & Weldon, S 2021, ' Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice ', Mediators of Inflammation, vol. 2021, 6682657 . https://doi.org/10.1155/2021/6682657
Brown, R, Small, D, Doherty, D F, Holsinger, L, Booth, R, Williams, R, Ingram, R J, Elborn, J S, Mall, M A, Taggart, C C & Weldon, S 2021, ' Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice ', Mediators of Inflammation, vol. 2021, 6682657 . https://doi.org/10.1155/2021/6682657
Background. Elevated levels of the cysteine protease cathepsin S (CatS) are associated with chronic mucoobstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). We have previously demonstrated that prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795b2bce1370ea9d46c956765f879ac8
Autor:
Ryan, Brown, Donna M, Small, Declan F, Doherty, Leslie, Holsinger, Robert, Booth, Richard, Williams, Rebecca J, Ingram, J Stuart, Elborn, Marcus A, Mall, Clifford C, Taggart, Sinéad, Weldon
Publikováno v:
Mediators of Inflammation
Background Elevated levels of the cysteine protease cathepsin S (CatS) are associated with chronic mucoobstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). We have previously demonstrated that proph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc5659bd07a00443b8423240e8332cef
https://pubmed.ncbi.nlm.nih.gov/33828414
https://pubmed.ncbi.nlm.nih.gov/33828414
Autor:
Anthony Abladey, Robert Booth, Leslie Holsinger, Declan Doherty, Ryan Brown, Zhe Zhou-Suckow, Donna M. Small, Christopher J. Scott, Caoifa M. Dougan, Lauren Kerrigan, Sinéad Weldon, Rebecca Delaney, Marcus A. Mall, Guillermo Lopez-Campos, J. Stuart Elborn, Keren S. Borensztajn, Clifford C. Taggart
Publikováno v:
Small, D M, Brown, R R, Doherty, D F, Abladey, A, Zhou-Suckow, Z, Delaney, R J, Kerrigan, L, Dougan, C M, Borensztajn, K S, Holsinger, L, Booth, R, Scott, C J, Lopez Campos, G, Elborn, J S, Mall, M A, Weldon, S & Taggart, C C 2019, ' Targeting of Cathepsin S Reduces Cystic Fibrosis-like Lung Disease ', European Respiratory Journal, vol. 53, no. 3, 1801523 . https://doi.org/10.1183/13993003.01523-2018
Cathepsin S (CatS) is upregulated in the lungs of patients with cystic fibrosis (CF). However, its role in CF lung disease pathogenesis remains unclear.In this study, β-epithelial Na+channel-overexpressing transgenic (βENaC-Tg) mice, a model of CF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13462c499642494e0b572c85f3abf95
https://doi.org/10.1183/13993003.01523-2018
https://doi.org/10.1183/13993003.01523-2018
Autor:
Cliff Taggart, Anthony Abladey, Sinéad Weldon, Leslie Holsinger, Donna M. Small, Marcus A. Mall, Robert Booth, Ryan Brown, Christopher J. Scott, Stuart Elborn
Publikováno v:
Web of Science
Elevated levels of the cysteine protease cathepsin S (cat S) are found in cystic fibrosis (CF) lung secretions, however, the role of cat S in CF lung disease is unclear. Cat S is capable of maintaining its activity at a neutral pH allowing it to rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16f55df415608a553747f340b949e28
https://doi.org/10.1055/s-0036-1584637
https://doi.org/10.1055/s-0036-1584637
Autor:
Leslie Holsinger
Publikováno v:
Journal of the American Academy of Dermatology. 51
a humanized monoclonal antibody against the CD11a chain of LFA-1. This rapidly acting drug has recently gained approval. Once activated, T-cells result in release of cytokines, including tumor necrosis factor a (TNF-a), which initiates a cascade of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67480481f769a7122dd236af0531a9fa
https://pubmed.ncbi.nlm.nih.gov/15243506
https://pubmed.ncbi.nlm.nih.gov/15243506
Autor:
Edward J. Bilsky, Jeffrey M. Dener, Todd W. Vanderah, Joshua Havelin, Robert Booth, Alysia Ondoua-Lozano, Leslie Holsinger, Katherine E. Hanlon, Jade Rodriguez
Publikováno v:
Molecular Cancer Therapeutics. 10:A219-A219
Introduction: Increased cathepsin levels and activity have been shown to play a role in a variety of tumors, including lung and breast malignancies, and are correlated to poor patient prognosis. Proteolytic activity of cathepsins S, L, B and K may pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ed138e2308ad12261524a654fd79069
https://doi.org/10.1158/1535-7163.targ-11-a219
https://doi.org/10.1158/1535-7163.targ-11-a219