Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Leslie Hesnard"'
Autor:
Leslie Hesnard, Catherine Thériault, Maxime Cahuzac, Chantal Durette, Krystel Vincent, Marie-Pierre Hardy, Joël Lanoix, Gabriel Ouellet Lavallée, Juliette Humeau, Pierre Thibault, Claude Perreault
Publikováno v:
Current Oncology, Vol 31, Iss 6, Pp 3099-3121 (2024)
Epithelial ovarian cancer (EOC) has not significantly benefited from advances in immunotherapy, mainly because of the lack of well-defined actionable antigen targets. Using proteogenomic analyses of primary EOC tumors, we previously identified 91 abe
Externí odkaz:
https://doaj.org/article/12eb4b94c81d4840bf379764f030a99c
Autor:
Jean-David Larouche, Céline M Laumont, Assya Trofimov, Krystel Vincent, Leslie Hesnard, Sylvie Brochu, Caroline Côté, Juliette F Humeau, Éric Bonneil, Joel Lanoix, Chantal Durette, Patrick Gendron, Jean-Philippe Laverdure, Ellen R Richie, Sébastien Lemieux, Pierre Thibault, Claude Perreault
Publikováno v:
eLife, Vol 12 (2024)
Transposable elements (TEs) are repetitive sequences representing ~45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTECs). In this study, we investigated the role of TEs on T-cell development in the t
Externí odkaz:
https://doaj.org/article/f8e5dc8f11474cf292db53bbc1880f9d
Autor:
Juliette Vaurs, Gaël Douchin, Klara Echasserieau, Romain Oger, Nicolas Jouand, Agnès Fortun, Leslie Hesnard, Mikaël Croyal, Frédéric Pecorari, Nadine Gervois, Karine Bernardeau
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Over the past two decades, there has been a great interest in the study of HLA-E-restricted αβ T cells during bacterial and viral infections, including recently SARS-CoV-2 infection. Phenotyping of these specific HLA-E-restricted T cells r
Externí odkaz:
https://doaj.org/article/890ce0d044f14d9ebfb2c8235af6b09b
Autor:
Jean-David Larouche, Assya Trofimov, Leslie Hesnard, Gregory Ehx, Qingchuan Zhao, Krystel Vincent, Chantal Durette, Patrick Gendron, Jean-Philippe Laverdure, Éric Bonneil, Caroline Côté, Sébastien Lemieux, Pierre Thibault, Claude Perreault
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-16 (2020)
Abstract Background Endogenous retroelements (EREs) constitute about 42% of the human genome and have been implicated in common human diseases such as autoimmunity and cancer. The dominant paradigm holds that EREs are expressed in embryonic stem cell
Externí odkaz:
https://doaj.org/article/d473cb8940d0454994221bb51e7f2e8e
Autor:
Céline Vandamme, Rebecca Xicluna, Leslie Hesnard, Marie Devaux, Nicolas Jaulin, Mickaël Guilbaud, Johanne Le Duff, Célia Couzinié, Philippe Moullier, Xavier Saulquin, Oumeya Adjali
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Pre-existing immunity to AAV capsid may compromise the safety and efficiency of rAAV-mediated gene transfer in patients. Anti-capsid cytotoxic immune responses have proven to be a challenge to characterize because of the scarcity of circulating AAV-s
Externí odkaz:
https://doaj.org/article/21c2793766ba4036b7fafebbf31d8574
Autor:
Eralda Kina, Jean-Philippe Laverdure, Chantal Durette, Joël Lanoix, Mathieu Courcelles, Qingchuan Zhao, Anca Apavaloaei, Jean-David Larouche, Marie-Pierre Hardy, Krystel Vincent, Patrick Gendron, Leslie Hesnard, Maria Virginia Ruiz Cuevas, Gregory Ehx, Pierre Thibault, Claude Perreault
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ce0c87ddfaa9a36d77aed928c68302
https://doi.org/10.1136/jitc-2022-sitc2022.1411
https://doi.org/10.1136/jitc-2022-sitc2022.1411
Autor:
Anca Apavaloaei, Qingchuan Zhao, Leslie Hesnard, Krystel Vincent, Marie-Pierre Hardy, Chantal Durette, Joël Lanoix, Jean-Philippe Laverdure, Jean-David Larouche, Maria Virginia Ruiz Cuevas, Grégory Ehx, Sébastien Lemieux, Pierre Thibault, Claude Perreault
Publikováno v:
Cancer Research. 83:2993-2993
Recognition of MHC-I-associated tumor antigens (TAs) by CD8+ T cells is central to antitumor immunity. Owing to the elevated tumor mutational burden (TMB) in melanoma, the marked efficacy of immune checkpoint blockade (ICB) has been attributed to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45f0051bce1b6848c7168e795c4d2af4
https://doi.org/10.1158/1538-7445.am2023-2993
https://doi.org/10.1158/1538-7445.am2023-2993
Autor:
Claude Perreault, Jean-Philippe Laverdure, Leslie Hesnard, Chantal Durette, Grégory Ehx, Patrick Gendron, Pierre Thibault, Sébastien Lemieux, Caroline Côté, Qingchuan Zhao, Assya Trofimov, Jean-David Larouche, Krystel Vincent, Eric Bonneil
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-16 (2020)
Genome Medicine
Genome Medicine
Background Endogenous retroelements (EREs) constitute about 42% of the human genome and have been implicated in common human diseases such as autoimmunity and cancer. The dominant paradigm holds that EREs are expressed in embryonic stem cells (ESCs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b7506a7a4cbf6f6d71279d9a0323bc
http://link.springer.com/article/10.1186/s13073-020-00740-7
http://link.springer.com/article/10.1186/s13073-020-00740-7
Autor:
Grégory Ehx, Krystel Vincent, Jean-David Larouche, Chantal Durette, Jean-Philippe Laverdure, Joël Lanoix, Eric Bonneil, Marie-Pierre Hardy, Caroline Coté, Nandita Noronha, Leslie Hesnard, Qingchuan Zhao, Céline M Laumont, Sébastien Lemieux, Pierre Thibault, Claude Perreault
Publikováno v:
Molecular Immunology. 150:8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb23c5e11e5b345123969f525ac50e05
https://doi.org/10.1016/j.molimm.2022.05.035
https://doi.org/10.1016/j.molimm.2022.05.035
Autor:
Anca Apavaloaei, Leslie Hesnard, Marie-Pierre Hardy, Basma Benabdallah, Gregory Ehx, Catherine Thériault, Jean-Philippe Laverdure, Chantal Durette, Joël Lanoix, Mathieu Courcelles, Nandita Noronha, Kapil Dev Chauhan, Sébastien Lemieux, Christian Beauséjour, Mick Bhatia, Pierre Thibault, Claude Perreault
Publikováno v:
Cell reports. 40(7)
Previous reports showed that mouse vaccination with pluripotent stem cells (PSCs) induces durable anti-tumor immune responses via T cell recognition of some elusive oncofetal epitopes. We characterize the MHC I-associated peptide (MAP) repertoire of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e85591d83ef99a24476ce98711c38e
https://pubmed.ncbi.nlm.nih.gov/35977509
https://pubmed.ncbi.nlm.nih.gov/35977509