Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Leslie E. Orgel"'
Publikováno v:
J Chem Technol Biotechnol
When [32P]-labeled DNA is adsorbed on colloidal gold from a 130 mmol dm−3 solution of KH2PO4, it can subsequently be eluted with cold DNA without undergoing detectable degradation. Similarly, DNA can be incubated in solution in the presence or abse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0493f2eb7436ff1863b141f61e5bda8
https://pubmed.ncbi.nlm.nih.gov/34083856
https://pubmed.ncbi.nlm.nih.gov/34083856
Autor:
Leslie E Orgel
Publikováno v:
PLoS Biology, Vol 6, Iss 1, p e18 (2008)
Externí odkaz:
https://doaj.org/article/12a66ee59b3a46019da0759c160d41c9
Autor:
Leslie E., Orgel1 (AUTHOR) orgel@salk.edu
Publikováno v:
Critical Reviews in Biochemistry & Molecular Biology. Mar/Apr2004, Vol. 39 Issue 2, p99-123. 25p.
Publikováno v:
Science. 325:73-77
Adaptable DNA Analogs The defining feature of DNA as a genetic blueprint is its capacity for self-replication. In the cell, however, the replication process requires the assistance of multiple elaborate enzymes. How then at the origin of life could D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b8f22ef7e1a3c186e1e1594cafd34a
https://doi.org/10.1126/science.1174577
https://doi.org/10.1126/science.1174577
Publikováno v:
Journal of Molecular Evolution. 64:15-32
Methionine sulfoxide reductases, enzymes that reverse the oxidation of methionine residues, have been described in a wide range of species. The reduction of the diastereoisomers of oxidized methionine is catalyzed by two different monomeric methionin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800c36d69fcbc3c88f0d156a34a10768
https://doi.org/10.1007/s00239-005-0281-2
https://doi.org/10.1007/s00239-005-0281-2
Publikováno v:
Science. 306:283-286
Almost all discussions of prebiotic chemistry assume that amino acids, nucleotides, and possibly other monomers were first formed on the Earth or brought to it in comets and meteorites, and then condensed nonenzymatically to form oligomeric products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a019c4ea3947cbd2ac8a62454608506c
https://doi.org/10.1126/science.1102722
https://doi.org/10.1126/science.1102722
Autor:
Leslie E. Orgel
Publikováno v:
Origins of Life and Evolution of the Biosphere. 34:361-369
Recent studies support an earlier suggestion that, if adenine was formed prebiotically on the primitive earth, eutectic freezing of hydrogen cyanide solutions is likely to have been important. Here we revisit the suggestion that the synthesis of aden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec478ff0d9c84f397d38bb8463308c73
https://doi.org/10.1023/b:orig.0000029882.52156.c2
https://doi.org/10.1023/b:orig.0000029882.52156.c2
Autor:
Leslie E. Orgel
Publikováno v:
Origins of Life and Evolution of the Biosphere. 33:211-218
It is now generally accepted that our familiar biological world was preceded by an RNA world in which ribosome-catalyzed, nucleic-acid coded protein synthesis played no part. If the RNA world was the first biological world there is little that one ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45cef97c9c1451bdfb65180e6c808a5f
https://doi.org/10.1023/a:1024616317965
https://doi.org/10.1023/a:1024616317965
Autor:
Leslie E. Orgel, Aubrey R. Hill
Publikováno v:
Origins of Life and Evolution of the Biosphere. 32:99-102
Adenine is formed in about 18% yield whenHCN tetramer is heated with ammonium formate at 110 °C. Theprebiotic significance of this reaction is discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aac3c0ebd86e291908ee9205af1b3ec5
https://doi.org/10.1023/a:1016070723772
https://doi.org/10.1023/a:1016070723772