Výsledky vyhledávání - "Leslie E. Lemke"

A comparison of the pharmacokinetics and NMDAR antagonism-associated neurotoxicity of ketamine, (2R,6R)-hydroxynorketamine and MK-801

Autor: Ruin Moaddel, Patrick J. Morris, Panos Zanos, Craig J. Thomas, Shiny Mathew, Daniel C. Lynch, Deepa B. Rao, Carlos A. Zarate, Todd D. Gould, Alok K. Sharma, Ikram Elayan, Leslie E. Lemke-Boutcher, Richard D. Burke

Publikováno v: Neurotoxicol Teratol

With the increasing use of ketamine as an off-label treatment for depression and the recent FDA approval of (S)-ketamine for treatment-resistant depression, there is an increased need to understand the long-term safety profile of chronic ketamine adm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f082041f070b8b89c5627e1c7843e8
https://doi.org/10.1016/j.ntt.2021.106993

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Decreased p38 MAPK activity in end-stage failing human myocardium: p38 MAPK alpha is the predominant isoform expressed in human heart

Autor: Michail A. Esterman, Rebecca L. Fouts, Laura J. Bloem, George E. Sandusky, Leslie E. Lemke, Chris J. Vlahos

Publikováno v: Journal of molecular and cellular cardiology. 33(8)

Short duration exposure to cellular stresses have been shown to activate p38 mitogen-activated protein kinase (MAPK) in cultured rat ventricular cardiomyocytes and isolated perfused hearts; however, effects of chronic stress on p38 MAPK are not well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa3fa58c01bba756f81383ba04804dd
https://pubmed.ncbi.nlm.nih.gov/11448140

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Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase

Autor: Charles W. Taylor, Garth Powis, Gillian Paine-Murrieta, Leslie E. Lemke

Publikováno v: Cancer chemotherapy and pharmacology. 44(6)

Purpose: Phosphatidylinositol (PtdIns) 3-kinase is an important mediator of many cellular functions. The study of PtdIns 3-kinase has been facilitated by the existence of the potent irreversible inhibitor of p110 PtdIns 3-kinase, wortmannin. The purp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb4d25a0cef6c5b4d277028da4e3256
https://pubmed.ncbi.nlm.nih.gov/10550570

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Safety of Ciprofloxacin and Dexamethasone in the Guinea Pig Middle Ear

Autor: G. Michael Wall, Richard A. Altschuler, David F. Dolan, Josef M. Miller, Leslie E. Lemke, David H. McGee, Diane M. Prieskorn

Publikováno v: Archives of Otolaryngology–Head & Neck Surgery. 135:575

To investigate the ototoxic potential of ciprofloxacin hydrochloride, 0.3%, plus dexamethasone, 0.1%, after administration to the guinea pig middle ear.Fifty guinea pigs were randomly assigned to 4 test groups of 10 animals each and 2 control groups

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079cd46ce6721d199e849bac0d4d2b22
https://doi.org/10.1001/archoto.2009.30

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