Zobrazeno 1 - 10
of 394
pro vyhledávání: '"Leslie Cope"'
Autor:
Marina Baretti, Ludmila Danilova, Jennifer N. Durham, Courtney B. Betts, Leslie Cope, Dimitrios N. Sidiropoulos, Joseph A. Tandurella, Soren Charmsaz, Nicole Gross, Alexei Hernandez, Won Jin Ho, Chris Thoburn, Rosalind Walker, James Leatherman, Sarah Mitchell, Brian Christmas, Ali Saeed, Daria A. Gaykalova, Srinivasan Yegnasubramanian, Elana J. Fertig, Lisa M. Coussens, Mark Yarchoan, Elizabeth Jaffee, Nilofer S. Azad
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDA) is characterized by low cytotoxic lymphocytes, abundant immune-suppressive cells, and resistance to immune checkpoint inhibitors (ICI). Preclinical PDA models showed the HDAC inhibitor entinostat reduce
Externí odkaz:
https://doaj.org/article/da588e36b348473cb1c930008d58747b
Autor:
Josh G. Chenoweth, Carlo Colantuoni, Deborah A. Striegel, Pavol Genzor, Joost Brandsma, Paul W. Blair, Subramaniam Krishnan, Elizabeth Chiyka, Mehran Fazli, Rittal Mehta, Michael Considine, Leslie Cope, Audrey C. Knight, Anissa Elayadi, Anne Fox, Ronna Hertzano, Andrew G. Letizia, Alex Owusu-Ofori, Isaac Boakye, Albert A. Aduboffour, Daniel Ansong, Eno Biney, George Oduro, Kevin L. Schully, Danielle V. Clark
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There is a critical lack of data from low- and middle-income countries where the sepsis
Externí odkaz:
https://doaj.org/article/81d492ccfe114c88a466b6acdd447d0a
Autor:
Mary Jo Fackler, Madison Pleas, Youran Li, Anushri Soni, Deyin Xing, Leslie Cope, Syed Ali, Quang Van Le, Chu Van Nguyen, Han Thi Pham, Long Minh Duong, Eunice Vanden Berg, Reubina Wadee, Pamela Michelow, Wenlong Carl Chen, Maureen Joffe, Christina Saetan Fjeldbo, Heidi Lyng, Saraswati Sukumar
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Cervical cancer remains a leading cause of death, particularly in developing countries. WHO screening guidelines recommend human papilloma virus (HPV) detection as a means to identify women at risk of developing cervical cancer. W
Externí odkaz:
https://doaj.org/article/7cd70d61abd64a239bb0607353d2dcbd
Autor:
Carlo Bifulco, Holden T Maecker, Leslie Cope, Tricia Cottrell, Sacha Gnjatic, Michael T Lotze, Laura Chow, Joe Yeong Poh Shen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)
Abstract
Externí odkaz:
https://doaj.org/article/2d74683ef3124eb98ba5727bc8362385
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
In this study, our goal was to determine probe-specific thresholds for identifying aberrant, or outlying, DNA methylation and to provide guidance on the relative merits of using continuous or outlier methylation data. To construct a reference databas
Externí odkaz:
https://doaj.org/article/dedf61dc6cbe44918ac5649f69bda5b1
Autor:
Yang Zhao, Christine M. O'Keefe, Kuangwen Hsieh, Leslie Cope, Sonali C. Joyce, Thomas R. Pisanic, James G. Herman, Tza‐Huei Wang
Publikováno v:
Advanced Science, Vol 10, Iss 16, Pp n/a-n/a (2023)
Abstract There remains tremendous interest in developing liquid biopsy assays for detection of cancer‐specific alterations, such as mutations and DNA methylation, in cell‐free DNA (cfDNA) obtained through noninvasive blood draws. However, liquid
Externí odkaz:
https://doaj.org/article/ff0a5e42f18e4cf0b64f4e54e2e61f2c
Publikováno v:
Epigenetics, Vol 17, Iss 2, Pp 191-201 (2022)
The contribution of DNA-methylation based gene silencing to carcinogenesis is well established. Increasingly, DNA-methylation is examined using genome-wide techniques, with recent public efforts yielding immense data sets of diverse malignancies repr
Externí odkaz:
https://doaj.org/article/58daba9259c643ea8da3f38b15c66f5d
Autor:
Justin Thomas, Ludovic Zimmerlin, Jeffrey S. Huo, Michael Considine, Leslie Cope, Elias T. Zambidis
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)
Abstract Human pluripotent stem cells (hPSCs) can generate specialized cell lineages that have great potential for regenerative therapies and disease modeling. However, the developmental stage of the lineages generated from conventional hPSC cultures
Externí odkaz:
https://doaj.org/article/2d63db817ceb45c390898d2afa8999ce
Autor:
Kellie N. Smith, Nicolas J. Llosa, Tricia R. Cottrell, Nicholas Siegel, Hongni Fan, Prerna Suri, Hok Yee Chan, Haidan Guo, Teniola Oke, Anas H. Awan, Franco Verde, Ludmila Danilova, Valsamo Anagnostou, Ada J. Tam, Brandon S. Luber, Bjarne R. Bartlett, Laveet K. Aulakh, John-William Sidhom, Qingfeng Zhu, Cynthia L. Sears, Leslie Cope, William H. Sharfman, Elizabeth D. Thompson, Joanne Riemer, Kristen A. Marrone, Jarushka Naidoo, Victor E. Velculescu, Patrick M. Forde, Bert Vogelstein, Kenneth W. Kinzler, Nickolas Papadopoulos, Jennifer N. Durham, Hao Wang, Dung T. Le, Sune Justesen, Janis M. Taube, Luis A. Diaz, Julie R. Brahmer, Drew M. Pardoll, Robert A. Anders, Franck Housseau
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract Background Several predictive biomarkers are currently approved or are under investigation for the selection of patients for checkpoint blockade. Tumor PD-L1 expression is used for stratification of non-small cell lung (NSCLC) patients, with
Externí odkaz:
https://doaj.org/article/1bbf8602f6f8428183fdc7d49f984cca
Autor:
Liangfeng Han, Preethi Korangath, Nguyen K. Nguyen, Adam Diehl, Soonweng Cho, Wei Wen Teo, Leslie Cope, Manfred Gessler, Lewis Romer, Saraswati Sukumar
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Blocking tumor angiogenesis is an appealing therapeutic strategy, but to date, success has been elusive. We previously identified HEYL, a downstream target of Notch signaling, as an overexpressed gene in both breast cancer cells and as a tumor endoth
Externí odkaz:
https://doaj.org/article/a3f5d577b619444aa2f259fd26d9fc97