Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Leslie C. Jellen"'
Autor:
Leslie C. Jellen, Mechelle M. Lewis, Guangwei Du, Xi Wang, Martha L. Escobar Galvis, Stanislaw Krzyzanowski, Colt D. Capan, Amanda M. Snyder, James. R. Connor, Lan Kong, Richard B. Mailman, Patrik Brundin, Lena Brundin, Xuemei Huang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract A growing body of evidence suggests nigral iron accumulation plays an important role in the pathophysiology of Parkinson’s disease (PD), contributing to dopaminergic neuron loss in the substantia nigra pars compacta (SNc). Converging evide
Externí odkaz:
https://doaj.org/article/fd8171bac5ce4292afc8af308235a58c
Autor:
Ernest W. Wang, Gregory L. Brown, Mechelle M. Lewis, Leslie C. Jellen, Cunfeng Pu, Melinda L. Johnson, Hairong Chen, Lan Kong, Guangwei Du, Xuemei Huang
Publikováno v:
Movement disorders : official journal of the Movement Disorder SocietyReferences.
Susceptibility magnetic resonance imaging (MRI) is sensitive to iron-related changes in the substantia nigra pars compacta (SNc), the key pathologic locus of parkinsonisms. It is unclear, however, if iron deposition in the SNc is associated with its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6c5447fd4c3f5aac0b7ed3ee142304
https://pubmed.ncbi.nlm.nih.gov/36598274
https://pubmed.ncbi.nlm.nih.gov/36598274
Autor:
Mechelle M. Lewis, Gregory L. Brown, Elizabeth B. Neely, Leslie C Jellen, Guangwei Du, Ernest W. Wang, James R. Connor, Hairong Chen, Max L Trojano, Lan Kong, Insung Song, Xuemei Huang
Publikováno v:
Toxicol Sci
Paraquat is an herbicide whose use is associated with Parkinson’s disease (PD), a neurodegenerative disorder marked by neuron loss in the substantia nigra pars compacta (SNc). We recently observed that the murine homolog to the human H63D variant o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acb1c08ba21ada96642372fd818028d
https://pubmed.ncbi.nlm.nih.gov/33739421
https://pubmed.ncbi.nlm.nih.gov/33739421
Autor:
Franco Cortese, Darla Karpinsky-Semper, Alex Zhavoronkov, Leslie C. Jellen, Alexander Aliper, Artem V. Artemov, Andrew G. Swick, Alexey Moskalev
Publikováno v:
Aging (Albany NY)
Aging is now at the forefront of major challenges faced globally, creating an immediate need for safe, widescale interventions to reduce the burden of chronic disease and extend human healthspan. Metformin and rapamycin are two FDA-approved mTOR inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4085f985e3077bd427a25233052bfc2b
http://europepmc.org/articles/PMC5723685
http://europepmc.org/articles/PMC5723685
Autor:
Michael Korzinkin, Anton Buzdin, Alexander Aliper, Alex Zhavoronkov, Ksenia Lezhnina, N.V. Zhukov, Nurshat Gaifullin, Sergey A. Roumiantsev, Artem V. Artemov, Leslie C. Jellen, Nicolas Borisov
Publikováno v:
Oncotarget
A new generation of anticancer therapeutics called target drugs has quickly developed in the 21 st century. These drugs are tailored to inhibit cancer cell growth, proliferation, and viability by specific interactions with one or a few target protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b531da0f481fe57da2492892adb312
https://doi.org/10.18632/oncotarget.5119
https://doi.org/10.18632/oncotarget.5119
Autor:
Byron C. Jones, Leslie C. Jellen
Publikováno v:
Methods in Molecular Biology ISBN: 9781493964253
In this contribution, we demonstrate the utility of the systems genetics-systems biology approach to the study of iron regulation while employing a comprehensive database. We describe our work in iron regulation in the brain and periphery under norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6412b20fd3aa2938e341b27325081bf9
https://doi.org/10.1007/978-1-4939-6427-7_22
https://doi.org/10.1007/978-1-4939-6427-7_22
Autor:
Maria Suntsova, Anton Buzdin, Alexander Aliper, Evgeny Putin, Alex Zhavoronkov, Andrew Garazha, Polina Mamoshina, Larisa Venkova, Andrew G. Swick, Alexey Moskalev, Artem V. Artemov, Aleksey V. Belikov, Leslie C. Jellen, Alena Ivanova, Nicolas Borisov
Publikováno v:
Aging (Albany NY)
Populations in developed nations throughout the world are rapidly aging, and the search for geroprotectors, or anti-aging interventions, has never been more important. Yet while hundreds of geroprotectors have extended lifespan in animal models, none
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc8486f94c9bfc1f90899f36247a45a
https://pubmed.ncbi.nlm.nih.gov/27677171
https://pubmed.ncbi.nlm.nih.gov/27677171
Autor:
Mikhail Shaposhnikov, Alex Peregudov, Alex Zhavoronkov, Aleksandr Pashuk, Evgenia Dobrovolskaya, Alexey Moskalev, Svetlana Zhikrivetskaya, Roman Gurinovich, Leslie C. Jellen, Alexander Aliper, Oleg Kuryan
Publikováno v:
Nucleic Acids Research
Aging research is a multi-disciplinary field encompassing knowledge from many areas of basic, applied and clinical research. Age-related processes occur on molecular, cellular, tissue, organ, system, organismal and even psychological levels, trigger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fdd081caf431b3858717db13155e714
https://pubmed.ncbi.nlm.nih.gov/26602690
https://pubmed.ncbi.nlm.nih.gov/26602690
Autor:
Erica L. Unger, Xusheng Wang, Leslie C. Jellen, Lu Lu, Robert W. Williams, Richard P. Allen, Byron C. Jones, Christopher J. Earley
Publikováno v:
Neuroscience. 252
A clear link exists between iron deficiency (ID) and nigrostriatal dopamine malfunction. This link appears to play an important role in at least restless legs syndrome (RLS) if not several other neurological diseases. Yet, the underlying mechanisms r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252aeb09f5295fdb5f76bc88599cc90c
https://pubmed.ncbi.nlm.nih.gov/23911809
https://pubmed.ncbi.nlm.nih.gov/23911809
Autor:
Byron C. Jones, Lina Yin, Ann Tomaszewicz, Richard P. Allen, Leslie C. Jellen, James C. Fleet, Christopher J. Earley, Erica L. Unger
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 302(11)
The aim of this study was to identify genes that influence iron regulation under varying dietary iron availability. Male and female mice from 20+ BXD recombinant inbred strains were fed iron-poor or iron-adequate diets from weaning until 4 mo of age.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1c9a244d8557ce1c1e06a70a4e4746
https://pubmed.ncbi.nlm.nih.gov/22461179
https://pubmed.ncbi.nlm.nih.gov/22461179