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pro vyhledávání: '"Leslie C. Blaber"'
Publikováno v:
British Journal of Pharmacology. 86:723-728
In anaesthetized cats, stimulation of the vagus nerves produced bradycardia and a bronchoconstriction which was measured as an increase in lung resistance (RL) and a fall in dynamic lung compliance (Cdyn); these effects were abolished by atropine. Ga
Autor:
Rosemary A. Melarange, David Nigel Hurst, Peter James Machin, Celia Shivdasani, Rachel M. Bradshaw, David T. Burden, Allison D. Fryer, Leslie C. Blaber
Publikováno v:
Journal of medicinal chemistry. 26(11)
A series of 4-substituted phenoxypropanolamines was prepared and examined for beta-adrenoceptor activity. Some of the compounds, especially the [4-[2-[[2-(4-fluorophenyl)ethyl] oxy]ethoxy]phenoxy]propanolamines (14, 15, and 24), showed potent beta 1-