Regulatory cell therapy in kidney transplantation (The ONE Study):a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

Autor: Kathryn J. Wood, Birgit Sawitzki, James A. Hutchinson, Leslie Brent, Cristiano Scottà, Christoph Meyenberg, P Friend, Kerry Crisalli, Manuela Battaglia, Natalie M Otto, Ben James, Eva C. Guinan, M. C. Cuturi, Alexander Scheffold, William Petchey, Ulrich Kunzendorf, William J. Burlingham, Fadi Issa, Antonio Secchi, Petra Reinke, Giovanna Lombardi, James F. Markmann, Hans-Dieter Volk, David Game, Matthias Edinger, Norbert Ahrens, Ian S.D. Roberts, Michael Kapinsky, Maria P. Hernandez-Fuentes, Bernhard Banas, Sandra Karitzky, Nathalie Dupas, Carsten A. Böger, Edward K. Geissler, Tewfik Miloud, Stephan Schlickeiser, Paul N. Harden, Qizhi Tang, Gilles Blancho, Tobias Bergler, Karsten Juerchott, Robert I. Lechler, Hans J. Schlitt, Josep M. Grinyó, Laura Contreras-Ruiz, Rossana Caldara, Joanna Hester, Mathias Streitz, A. Bushell, Rachel Hilton, Régis Josien, Stuart J. Knechtle, Robert Öllinger, Laurence A. Turka, Cécile Braudeau, Aurélie Moreau, Peter J. Morris, Jeffrey A. Bluestone, Sang-Mo Kang, Ingrid Mutzbauer, Jeroen B. van der Net

Publikováno v: Sawitzki, B, Harden, P, Reinke, P, Moreau, A, Hutchinson, J A, Game, D S, Tang, Q, Guinan, E, Battaglia, M, Burlingham, W J, Roberts, I, Streitz, M, Josien, R, Böger, C A, Scotta, C, Markmann, J F, Hester, J, Juerchott, K, Braudeau, C, James, B, Contreras-Ruiz, L, van der Net, J B, Bergler, T, Caldara, R, Petchey, W, Edinger, M, Dupas, N, Kapinsky, M, Mutzbauer, I, Otto, N M, Ollinger, R, Hernandez Fuentes, M, Issa, F, Ahrens, N, Meyenberg, C, Karitzky, S, Kunzendorf, U, Knechtle, S J, Grinyo, J, Morris, P J, Brent, L, Bushell, A, Turka, L A, Bluestone, J A, Lechler, R, Schlitt, H J, Cuturi, M C, Schlickeiser, S, Friend, P J, Miloud, T, Scheffold, A, Secchi, A, Crisalli, K, Kang, S-M, Hilton, R, Banas, B, Blancho, G, Volk, H-D, Lombardi, G, Wood, K & Geissler, E K 2020, ' Regulatory cell therapy in kidney transplantation (The ONE Study) : a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials ', The Lancet, vol. 395, no. 10237, pp. 1627-1639 . https://doi.org/10.1016/S0140-6736(20)30167-7
Lancet (London, England), vol 395, iss 10237

Background:Use of cell-based medicinal products (CBMPs) represents a state-of-the-art approach for reducing general immunosuppression in organ transplantation. We tested multiple regulatory CBMPs in kidney transplant trials to establish the safety of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eeb3a2997cd38b689087979f243f237
https://kclpure.kcl.ac.uk/ws/files/125216985/AllTogetherFigs.pdf

Pillars Article: 'Activity Acquired Tolerance' of Foreign Cells Nature 172: 603-606

Autor: Leslie Brent, Rupert E. Billingham, Peter Medawar

Publikováno v: The Journal of Immunology. 184:5-8

(1) Mice and chickens never develop, or develop to only a limited degree, the power to react immunologically against foreign homologous tissue cells with which they have been inoculated in foetal life. Animals so treated are tolerant not only of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82ec4b01b6075bb27c6af724d4788f99
https://doi.org/10.4049/jimmunol.0990109

SUMMATION OF THE SEVENTH TRANSPLANTATION CONFERENCE

Autor: Leslie Brent

Publikováno v: Annals of the New York Academy of Sciences. 129:876-880

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a050e50b24472a475717f19b4b3ce6b2
https://doi.org/10.1111/j.1749-6632.1966.tb12904.x

‘Actively acquired tolerance’ of foreign cells1

Autor: Leslie Brent, Rupert E. Billingham, Peter Medawar

Publikováno v: Transplantation. 76:1409-1412

(1) Mice and chickens never develop, or develop to only a limited degree, the power to react immunologically against foreign homologous tissue cells with which they have been inoculated in foetal life. Animals so treated are tolerant not only of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45482e50786e1c9f61ed9fbefe6ce79c
https://doi.org/10.1097/01.tp.0000102675.72061.88

The 50th Anniversary of the Discovery of Immunologic Tolerance

Autor: Leslie Brent

Publikováno v: New England Journal of Medicine. 349:1381-1383

On October 3, 1953 — almost exactly half a century ago — Rupert E. Billingham, Peter B. Medawar, and I published a paper in Nature titled “‘Actively Acquired Tolerance' of Foreign Cells.”1 Medawar was the senior author, Billingham was his r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2c54d8e6b863b09e2b4e8a5ef99553
https://doi.org/10.1056/nejmon035589