Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Leslie A. Shinobu"'
Publikováno v:
Neurology
I read the editorial by Dr. Nath1 with interest. One aspect of the CNS involvement in SARS-CoV-2 infection that has attracted little interest so far is the medium- or long-term consequences on patients with neurodegenerative diseases (NDD). It is kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6497d10443ffaa34bf631fa32fb5c20c
https://pubmed.ncbi.nlm.nih.gov/32817356
https://pubmed.ncbi.nlm.nih.gov/32817356
Autor:
Amanda Dobbyn, Laura M. Huckins, James Boocock, Laura G. Sloofman, Benjamin S. Glicksberg, Claudia Giambartolomei, Gabriel E. Hoffman, Thanneer M. Perumal, Kiran Girdhar, Yan Jiang, Towfique Raj, Douglas M. Ruderfer, Robin S. Kramer, Dalila Pinto, Schahram Akbarian, Panos Roussos, Enrico Domenici, Bernie Devlin, Pamela Sklar, Eli A. Stahl, Solveig K. Sieberts, Joseph Buxbaum, David Lewis, Raquel Gur, Chang-Gyu Hahn, Keisuke Hirai, Hiroyoshi Toyoshiba, Laurent Essioux, Lara Mangravite, Mette Peters, Thomas Lehner, Barbara Lipska, A. Ercument Cicek, Cong Lu, Kathryn Roeder, Lu Xie, Konrad Talbot, Scott E. Hemby, Andrew Browne, Andrew Chess, Aaron Topol, Alexander Charney, Ben Readhead, Bin Zhang, David A. Bennett, David H. Kavanagh, Eric E. Schadt, Hardik R. Shah, Jun Zhu, Jessica S. Johnson, John F. Fullard, Joel T. Dudley, Kristen J. Brennand, Menachem Fromer, Milind C. Mahajan, Shaun M. Purcell, Tymor Hamamsy, Vahram Haroutunian, Ying-Chih Wang, Zeynep H. Gümüş, Geetha Senthil, Robin Kramer, Benjamin A. Logsdon, Jonathan M.J. Derry, Kristen K. Dang, Roberto Visintainer, Leslie A. Shinobu, Patrick F. Sullivan, Lambertus L. Klei
Publikováno v:
American Journal of Human Genetics
Causal genes and variants within genome-wide association study (GWAS) loci can be identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and determining which variants underlie both GWAS and eQTL signals. Most analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2195e247d6f51da5e445339e007da95
https://doi.org/10.1016/j.ajhg.2018.04.011
https://doi.org/10.1016/j.ajhg.2018.04.011
Publikováno v:
Neurobiology of Disease, Vol 53, Iss , Pp 1-2 (2013)
Externí odkaz:
https://doaj.org/article/c03a1c37cffa4c58a9ca5290a69f2e4d
Autor:
Keisuke Hirai, Joseph D. Buxbaum, Robin Kramer, Li Xie, Kristen K. Dang, Kathryn Roeder, Towfique Raj, Barbara K. Lipska, Shaun Purcell, Lambertus Klei, Panos Roussos, John F. Fullard, Vahram Haroutonian, A. Ercument Cicek, Konrad Talbot, Raquel E. Gur, Solveig K. Sieberts, Scott E. Hemby, Leslie A. Shinobu, Jun Zhu, Mette A. Peters, Pamela Sklar, Kristen J. Brennand, Aaron Topol, David A. Lewis, Mahsa Parvisi, Chang-Gyu Hahn, Ying-Chih Wang, Menachem Fromer, Nicholas Katsanis, Jessica S. Johnson, David A. Bennett, Andrew W. Browne, Zeynep H. Gümüş, Jonathan M. J. Derry, Ben Readhead, Edwin C. Oh, Benjamin A. Logsdon, Dalila Pinto, Cong Lu, David H. Kavanagh, Eli A. Stahl, Lara M. Mangravite, Enrico Domenici, Thanneer M. Perumal, Milind Mahajan, Douglas M. Ruderfer, Philip L. De Jager, Patrick F. Sullivan, Hiroyoshi Toyoshiba, Hardik Shah, Andrew Chess, Bin Zhang, Bernie Devlin, Joel T. Dudley, Tymor Hamamsy, Eric E. Schadt
Over 100 genetic loci harbor schizophrenia associated variants, yet how these common variants confer risk is uncertain. The CommonMind Consortium has sequenced dorsolateral prefrontal cortex RNA from schizophrenia cases (n=258) and control subjects (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08d72b0f3ac51e7b3a9ec731cc826bc
https://doi.org/10.1101/052209
https://doi.org/10.1101/052209
Autor:
David A. Lewis, Lara M. Mangravite, Bernie Devlin, Hardik Shah, Andrew Chess, Keisuke Hirai, Ben Readhead, Patrick F. Sullivan, Kathryn Roeder, Robin Kramer, Chang-Gyu Hahn, Shaun Purcell, Mahsa Parvisi, Cong Lu, Nicholas Katsanis, Edwin C. Oh, Douglas M. Ruderfer, Solveig K. Sieberts, David H. Kavanagh, Thanneer M. Perumal, Eli A. Stahl, Jessica S. Johnson, Mette A. Peters, Milind Mahajan, Panos Roussos, Menachem Fromer, David A. Bennett, Hiroyoshi Toyoshiba, Kristen K. Dang, Lambertus Klei, Tymor Hamamsy, Philip L. De Jager, Joseph D. Buxbaum, Jianqiu Xiao, Vahram Haroutunian, Barbara K. Lipska, Jun Zhu, Jonathan M. J. Derry, Kristen J. Brennand, A. Ercument Cicek, Ying-Chih Wang, Benjamin A. Logsdon, Dalila Pinto, Andrew W. Browne, Konrad Talbot, Eric E. Schadt, Scott E. Hemby, Bin Zhang, Raquel E. Gur, Leslie A. Shinobu, Towfique Raj, Joel T. Dudley, Enrico Domenici, Pamela Sklar, John F. Fullard, Zeynep H. Gümüş, Lu Xie, Aaron Topol
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of people with schizophrenia (N = 258) and control subje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b63f18526b34f2180c0c06d91993185
Publikováno v:
Journal of Neurochemistry. 93:875-882
Mutations in copper/zinc superoxide dismutase (SOD1) account for 10-20% of a familial form of amyotrophic lateral sclerosis (ALS). A common feature of SOD1 mutants is abnormal aggregation of the aberrant SOD1 in neurons and glia. We now report that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a657fa4b1849134bdd0e20a7b22c77f
https://doi.org/10.1111/j.1471-4159.2005.03054.x
https://doi.org/10.1111/j.1471-4159.2005.03054.x
Autor:
Leslie A. Shinobu, Bowling Ac, Robert H. Brown, M. J. Baik, Usha MacGarvey, Robert J. Ferrante, M F Beal, Neil W. Kowall, Susan E. Browne
Publikováno v:
Journal of Neurochemistry. 69:2064-2074
Some cases of autosomal dominant familial amyotrophic lateral sclerosis (FALS) are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1), suggesting that oxidative damage may play a role in ALS pathogenesis. To further inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f41b246f9baf1d6837f830523628ba
https://doi.org/10.1046/j.1471-4159.1997.69052064.x
https://doi.org/10.1046/j.1471-4159.1997.69052064.x
Autor:
Leslie A. Shinobu, Péter Klivényi, M. Flint Beal, Robert J. Ferrante, Ole A. Andreassen, Autumn M. Klein, Charles J. Epstein
Publikováno v:
Annals of Neurology. 47:447-455
The pathogenesis of neuronal cell death as a consequence of mutations in copper/zinc superoxide dismutase (SOD1) associated with familial amyotrophic lateral sclerosis may involve oxidative damage and mitochondrial dysfunction. We examined whether cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32089ddf7086789afe79fc7fb22908d8
https://doi.org/10.1002/1531-8249(200004)47:4<447::aid-ana7>3.0.co
https://doi.org/10.1002/1531-8249(200004)47:4<447::aid-ana7>3.0.co
Publikováno v:
Journal of Neurosurgery. 92:375-383
Object. Pallidotomy for the treatment of medically refractory Parkinson's disease (PD) has enjoyed renewed popularity. However, the optimal surgical technique, lesion location, and long-term effectiveness of pallidotomy remain subjects of debate. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1618713f0b4fa789806db82a5cc2cf
https://doi.org/10.3171/jns.2000.92.3.0375
https://doi.org/10.3171/jns.2000.92.3.0375
Autor:
Matthew P. Frosch, Leslie A. Shinobu
Publikováno v:
New England Journal of Medicine. 341:901-908
Presentation of Case A 68-year-old woman was admitted to the hospital because of rapidly progressive dementia and a gait disorder. The patient had been well until about one year earlier, when she began to have vague problems with her memory. Three mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df4df1c237b137396c107956be7f8235
https://doi.org/10.1056/nejm199909163411208
https://doi.org/10.1056/nejm199909163411208