Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Leslie A. Chambers"'
Autor:
Yi Lu, Jotham Wadsworth Coe, Thomas I. Davis, David W. Schulz, Lorraine A. Lebel, Robert S. Mansbach, Paige Roanne Palmer Brooks, Michael C. Wirtz, Alka Shrikhande, Michael G. Vetelino, Leslie K. Chambers, Eric P. Arnold, Eric Schaeffer, Brian T. O’Neill, Steven B. Sands, and F. David Tingley, James Heym, Carol B. Fox, Huang Jianhua, Charles C. Rovetti, Hans Rollema
Publikováno v:
Modern Drug Synthesis
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine) has been identified for smoking cessation. Neuronal nicotinic acetylcholine receptors (nAChRs) mediate the dep
Autor:
Sarah S. Jaw-Tsai, Kathy Steece-Collier, Frank S. Menniti, J. Timothy Greenamyre, Leslie K. Chambers
Publikováno v:
Experimental Neurology. 163:239-243
In the setting of nigrostriatal dopamine depletion, glutamatergic pathways to the striatum and basal ganglia output nuclei become overactive. Systemically administered glutamate receptor antagonists may have direct antiparkinsonian actions in rodents
Publikováno v:
Psychopharmacology. 148:234-242
Rationale: The cellular effects of nicotine underlying its addictive liability are thought to be mediated by neuronal nicotinic receptors (nACHRs) in the central nervous system. It is believed that densely expressed β2-containing nACHRs in the centr
Publikováno v:
Journal of bacteriology. 52
Autor:
Martin J. Pagnozzi, R. T. Ronau, D. L. De Costa, Butler Todd W, I. A. Shalaby, M. F. Ducat, J. Z. Stemple, M. A. Collins, Karl E.G. Richter, E. Edward Mena, Leslie K. Chambers, M. L. Dumont, Bertrand L. Chenard, Frank S. Menniti, Carol B. Fox, W. F. White, Jon Bordner, J. A. Nielsen
Publikováno v:
ChemInform. 26
Autor:
Steven B. Sands, Leslie K. Chambers, Eric Schaeffer, Raymond S. Hurst, Robert S. Mansbach, J. Glowa, Hans Rollema, F. D. Tingley, Charles C. Rovetti, Yi Lu, David W. Schulz, Robert J. Mather, Jotham Wadsworth Coe, Lorraine A. Lebel, Kathryn E. Williams
Publikováno v:
Neuropharmacology. 52(3)
The preclinical pharmacology of the alpha4beta2 nicotinic acetylcholine receptor (nAChR) partial agonist varenicline, a novel smoking cessation agent is described. Varenicline binds with subnanomolar affinity only to alpha4beta2 nAChRs and in vitro f
Autor:
Leslie K. Chambers, E. Edward Mena, Butler Todd W, M. L. Dumont, Bertrand L. Chenard, M. F. Ducat, Jon Bordner, Carol B. Fox, M. A. Collins, De Costa Dl
Publikováno v:
Journal of medicinal chemistry. 38(16)
(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol (20, CP-101,606) has been identified as a potent and selective N-methyl-D-aspartate (NMDA) antagonist through a structure activity relation (SAR) program based on ifenprodil, a k
Autor:
Jotham Wadsworth Coe, Hans Rollema, Alka Shrikhande, Lorraine A. Lebel, Steven B. Sands, Carol B. Fox, Paige Roanne Palmer Brooks, Leslie K. Chambers, Charles C. Rovetti, Robert S. Mansbach, Michael C. Wirtz, Brian T. O’Neill, F. David Tingley, David W. Schulz, Thomas I. Davis, Michael G. Vetelino, Eric P. Arnold
Publikováno v:
Biochemical Pharmacology. 78:919
Autor:
Leslie A. Chambers
Publikováno v:
Journal of the Air Pollution Control Association. 5:142-185
Autor:
Leslie A. Chambers, Jean R. Clawson
Publikováno v:
The Journal of Immunology. 65:451-457
Summary Commercial epidemic typhus vaccines may be fractionated by centrifugation at 5000 rpm for 1 hour, or by sedimentation in a Sharples supercentrifuge operated at 50,000 rpm with a flow rate of 10 to 15 liters per hour. The supernatant fluids fr