Zobrazeno 1 - 10
of 272
pro vyhledávání: '"Leslie A. Bateman"'
Autor:
Susan Cantin, Alan F. Corin, Matthew T. Labenski, Lukas T. Voortman, Lixin Qiao, Giulia Giammo, Leslie A. Bateman
Publikováno v:
Biochemistry. 60:2915-2924
The streptavidin mass shift (SMaSh) assay is a robust and fast approach for quantifying target protein occupancy by a covalent inhibitor or ligand. It exploits the biotin-streptavidin bond using the Simple Western platform. One measurement on a singl
Autor:
Joel W, Thompson, Thomas, Clayton, Gody, Khambatta, Leslie A, Bateman, Christopher W, Carroll, Philip P, Chamberlain, Mary E, Matyskiela
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2365
Targeted protein degradation is garnering increased attention as a therapeutic modality due in part to its promise of modulating targets previously considered undruggable. Cereblon E3 Ligase Modulating Drugs (CELMoDs) are one of the most well-charact
Autor:
Philip P Chamberlain, Gody Khambatta, Leslie A. Bateman, Christopher W Carroll, Joel W Thompson, Mary E Matyskiela, Thomas Clayton
Publikováno v:
Targeted Protein Degradation ISBN: 9781071616642
Targeted protein degradation is garnering increased attention as a therapeutic modality due in part to its promise of modulating targets previously considered undruggable. Cereblon E3 Ligase Modulating Drugs (CELMoDs) are one of the most well-charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df1fc6b3c0228909d340f5ea6385a428
https://doi.org/10.1007/978-1-0716-1665-9_15
https://doi.org/10.1007/978-1-0716-1665-9_15
Autor:
Leslie A. Bateman, Laurie LeBrun, Philip P Chamberlain, Mary E. Matyskiela, Thomas Clayton, Joel W Thompson, Christopher W Carroll
Publikováno v:
Protein Degradation with New Chemical Modalities ISBN: 9781788016865
CELMoDs (cereblon E3 ligase-modulating drugs) are low-molecular-weight small molecules that induce the recruitment of specific protein targets to the cereblon-CRL4 ubiquitin ligase for ubiquitination and subsequent cellular degradation. CELMoDs act t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd46812805ee5223479388d367cb0b2c
https://doi.org/10.1039/9781839160691-00094
https://doi.org/10.1039/9781839160691-00094
Autor:
Daniel K. Nomura, Leslie A. Bateman, Carlo M. Contreras, Wan-min Ku, Christine F. Skibola, Martin J. Heslin
Publikováno v:
ACS Chemical Biology. 12:905-911
Like many cancer types, colorectal cancers have dysregulated metabolism that promotes their pathogenic features. In this study, we used the activity-based protein profiling chemoproteomic platform to profile cysteine-reactive metabolic enzymes that a
Autor:
Carlo M. Contreras, Tucker R. Huffman, Ashley N. Ives, David Akopian, David K. Miyamoto, Allison M. Roberts, Daniel K. Nomura, Christine F. Skibola, Leslie A. Bateman, Martin J. Heslin, Michael Rape
Publikováno v:
ACS Chemical Biology. 12:899-904
Chemical genetic screening of small-molecule libraries has been a promising strategy for discovering unique and novel therapeutic compounds. However, identifying the targets of lead molecules that arise from these screens has remained a major bottlen
Autor:
Daniel K. Nomura, Theodore M. Kamenecka, Patrick R. Griffin, Leslie A. Bateman, Bruce M. Spiegelman, Hua Lin, Katrin J. Svensson, Jonathan Z. Long, Mi Ra Chang, Rajesh R. Rao, Joao A. Paulo, Steven P. Gygi, Isha A. Lokurkar, Mark P. Jedrychowski, Jesse Lou
Publikováno v:
Cell, vol 166, iss 2
Summary Brown and beige adipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energy as heat. These cells likely possess alternative UCP1-independent thermogenic mechanisms. Here, we identify a secreted enzy
Autor:
Jonathan Z, Long, Alexander M, Roche, Charles A, Berdan, Sharon M, Louie, Amanda J, Roberts, Katrin J, Svensson, Florence Y, Dou, Leslie A, Bateman, Amir I, Mina, Zhaoming, Deng, Mark P, Jedrychowski, Hua, Lin, Theodore M, Kamenecka, John M, Asara, Patrick R, Griffin, Alexander S, Banks, Daniel K, Nomura, Bruce M, Spiegelman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Bioactive lipids control a wide variety of physiologic processes. We have recently identified a branch of bioactive lipid signaling mediated by N-acyl amino acids (NAAs) and the circulating enzyme peptidase M20 domain-containing 1 (PM20D
Autor:
Mark P. Jedrychowski, Charles A. Berdan, Zhaoming Deng, Katrin J. Svensson, Amanda J. Roberts, Amir I. Mina, Jonathan Z. Long, John M. Asara, Bruce M. Spiegelman, Sharon M. Louie, Theodore M. Kamenecka, Hua Lin, Daniel K. Nomura, Patrick R. Griffin, Leslie A. Bateman, Florence Y. Dou, Alexander S. Banks, Alexander M. Roche
Publikováno v:
Proceedings of the National Academy of Sciences. 115
N-acyl amino acids (NAAs) are a structurally diverse class of bioactive signaling lipids whose endogenous functions have largely remained uncharacterized. To clarify the physiologic roles of NAAs, we generated mice deficient in the circulating enzyme
Autor:
Daniel Gentile, Meredith L. Jenkins, Kevan M. Shokat, John E. Burke, Nir London, Daniel K. Nomura, Leslie A. Bateman, Chimno I Nnadi, Daniel Zaidman, Trent E. Balius
Publikováno v:
Journal of chemical information and modeling, vol 58, iss 2
The success of targeted covalent inhibitors in the global pharmaceutical industry has led to a resurgence of covalent drug discovery. However, covalent inhibitor design for flexible binding sites remains a difficult task due to a lack of methodologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e246e8a4b9a1dde427eae062510acc24
https://escholarship.org/uc/item/95j8d04k
https://escholarship.org/uc/item/95j8d04k