Zobrazeno 1 - 10
of 352
pro vyhledávání: '"Leslie A Lange"'
Autor:
Iain R Konigsberg, Thao Vu, Weixuan Liu, Elizabeth M Litkowski, Katherine A Pratte, Luciana B Vargas, Niles Gilmore, Mohamed Abdel-Hafiz, Ani Manichaikul, Michael H Cho, Craig P Hersh, Dawn L DeMeo, Farnoush Banaei-Kashani, Russell P Bowler, Leslie A Lange, Katerina J Kechris
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract Background Studies have identified individual blood biomarkers associated with chronic obstructive pulmonary disease (COPD) and related phenotypes. However, complex diseases such as COPD typically involve changes in multiple molecules with i
Externí odkaz:
https://doaj.org/article/21fb08f3af604e63b653fd7e059bb9fd
Autor:
Min-Zhi Jiang, François Aguet, Kristin Ardlie, Jiawen Chen, Elaine Cornell, Dan Cruz, Peter Durda, Stacey B Gabriel, Robert E Gerszten, Xiuqing Guo, Craig W Johnson, Silva Kasela, Leslie A Lange, Tuuli Lappalainen, Yongmei Liu, Alex P Reiner, Josh Smith, Tamar Sofer, Kent D Taylor, Russell P Tracy, David J VanDenBerg, James G Wilson, Stephen S Rich, Jerome I Rotter, Michael I Love, Laura M Raffield, Yun Li, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Analysis Working Group
Publikováno v:
PLoS Genetics, Vol 19, Iss 5, p e1010517 (2023)
Integrative approaches that simultaneously model multi-omics data have gained increasing popularity because they provide holistic system biology views of multiple or all components in a biological system of interest. Canonical correlation analysis (C
Externí odkaz:
https://doaj.org/article/98cb75bd5fb04c1883187221a94d546b
Autor:
Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E Huffman, Elizabeth Litkowski, Chang Liu, Yuk-Lam A Ho, Haley Hunter-Zinck, Hongyu Zhao, Eirini Marouli, Kari E North, VA Million Veteran Program, Ethan Lange, Leslie A Lange, Benjamin F Voight, J Michael Gaziano, Saiju Pyarajan, Elizabeth R Hauser, Philip S Tsao, Peter W F Wilson, Kyong-Mi Chang, Kelly Cho, Christopher J O'Donnell, Yan V Sun, Themistocles L Assimes
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010193 (2022)
BackgroundHeight has been associated with many clinical traits but whether such associations are causal versus secondary to confounding remains unclear in many cases. To systematically examine this question, we performed a Mendelian Randomization-Phe
Externí odkaz:
https://doaj.org/article/fe289ba2d0234778aa4b6385c94c9f97
Autor:
A Parker Ruhl, Neal Jeffries, Yu Yang, Orlando M Gutierrez, Paul Muntner, Rakhi P Naik, Lydia H Pecker, Bryan T Mott, Neil A Zakai, Monika M Safford, Leslie A Lange, Cheryl A Winkler, Marguerite R Irvin, Mary Cushman, Hans C Ackerman
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271031 (2022)
BackgroundAlpha globin is expressed in the endothelial cells of human resistance arteries where it binds to endothelial nitric oxide synthase and limits release of the vasodilator nitric oxide. Genomic deletion of the alpha globin gene (HBA) is commo
Externí odkaz:
https://doaj.org/article/54bce871f0964ea682c530e0dfd43e9d
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255609 (2021)
BackgroundAfrican ancestry individuals with comparable overall anthropometric measures to Europeans have lower abdominal adiposity. To explore the genetic underpinning of different adiposity patterns, we investigated whether genetic risk scores for w
Externí odkaz:
https://doaj.org/article/269d1fe6535647a7b41ddafd3c11d0c4
Autor:
Colton Leavitt, Neil A Zakai, Paul Auer, Mary Cushman, Ethan M Lange, Emily B Levitan, Nels Olson, Timothy A Thornton, Russell P Tracy, James G Wilson, Leslie A Lange, Alex P Reiner, Laura M Raffield
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231013 (2020)
Biomarkers of chronic inflammation (such as C-reactive protein) have long been associated with cardiovascular disease and mortality; however, biomarkers involved in antiviral cytokine induction and adaptive immune system activation remain largely une
Externí odkaz:
https://doaj.org/article/5e4f3bd994644621ba2daf027309147b
Autor:
Cassandra N Spracklen, Jinxiu Shi, Swarooparani Vadlamudi, Ying Wu, Meng Zou, Chelsea K Raulerson, James P Davis, Monica Zeynalzadeh, Kayla Jackson, Wentao Yuan, Haifeng Wang, Weihua Shou, Ying Wang, Jingchun Luo, Leslie A Lange, Ethan M Lange, Barry M Popkin, Penny Gordon-Larsen, Shufa Du, Wei Huang, Karen L Mohlke
Publikováno v:
PLoS Genetics, Vol 14, Iss 4, p e1007275 (2018)
To identify genetic contributions to type 2 diabetes (T2D) and related glycemic traits (fasting glucose, fasting insulin, and HbA1c), we conducted genome-wide association analyses (GWAS) in up to 7,178 Chinese subjects from nine provinces in the Chin
Externí odkaz:
https://doaj.org/article/2f4c9552e17c4607a5f338d225ffa92d
Autor:
Laura M Raffield, Jacob C Ulirsch, Rakhi P Naik, Samuel Lessard, Robert E Handsaker, Deepti Jain, Hyun M Kang, Nathan Pankratz, Paul L Auer, Erik L Bao, Joshua D Smith, Leslie A Lange, Ethan M Lange, Yun Li, Timothy A Thornton, Bessie A Young, Goncalo R Abecasis, Cathy C Laurie, Deborah A Nickerson, Steven A McCarroll, Adolfo Correa, James G Wilson, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Hematology & Hemostasis, Diabetes, and Structural Variation TOPMed Working Groups, Guillaume Lettre, Vijay G Sankaran, Alex P Reiner
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007293 (2018)
Co-inheritance of α-thalassemia has a significant protective effect on the severity of complications of sickle cell disease (SCD), including stroke. However, little information exists on the association and interactions for the common African ancest
Externí odkaz:
https://doaj.org/article/9ca17fd0506d404caeb1d4f46a790b11
Autor:
Maggie C Y Ng, Mariaelisa Graff, Yingchang Lu, Anne E Justice, Poorva Mudgal, Ching-Ti Liu, Kristin Young, Lisa R Yanek, Mary F Feitosa, Mary K Wojczynski, Kristin Rand, Jennifer A Brody, Brian E Cade, Latchezar Dimitrov, Qing Duan, Xiuqing Guo, Leslie A Lange, Michael A Nalls, Hayrettin Okut, Salman M Tajuddin, Bamidele O Tayo, Sailaja Vedantam, Jonathan P Bradfield, Guanjie Chen, Wei-Min Chen, Alessandra Chesi, Marguerite R Irvin, Badri Padhukasahasram, Jennifer A Smith, Wei Zheng, Matthew A Allison, Christine B Ambrosone, Elisa V Bandera, Traci M Bartz, Sonja I Berndt, Leslie Bernstein, William J Blot, Erwin P Bottinger, John Carpten, Stephen J Chanock, Yii-Der Ida Chen, David V Conti, Richard S Cooper, Myriam Fornage, Barry I Freedman, Melissa Garcia, Phyllis J Goodman, Yu-Han H Hsu, Jennifer Hu, Chad D Huff, Sue A Ingles, Esther M John, Rick Kittles, Eric Klein, Jin Li, Barbara McKnight, Uma Nayak, Barbara Nemesure, Adesola Ogunniyi, Andrew Olshan, Michael F Press, Rebecca Rohde, Benjamin A Rybicki, Babatunde Salako, Maureen Sanderson, Yaming Shao, David S Siscovick, Janet L Stanford, Victoria L Stevens, Alex Stram, Sara S Strom, Dhananjay Vaidya, John S Witte, Jie Yao, Xiaofeng Zhu, Regina G Ziegler, Alan B Zonderman, Adebowale Adeyemo, Stefan Ambs, Mary Cushman, Jessica D Faul, Hakon Hakonarson, Albert M Levin, Katherine L Nathanson, Erin B Ware, David R Weir, Wei Zhao, Degui Zhi, Bone Mineral Density in Childhood Study (BMDCS) Group, Donna K Arnett, Struan F A Grant, Sharon L R Kardia, Olufunmilayo I Oloapde, D C Rao, Charles N Rotimi, Michele M Sale, L Keoki Williams, Babette S Zemel, Diane M Becker, Ingrid B Borecki, Michele K Evans, Tamara B Harris, Joel N Hirschhorn, Yun Li, Sanjay R Patel, Bruce M Psaty, Jerome I Rotter, James G Wilson, Donald W Bowden, L Adrienne Cupples, Christopher A Haiman, Ruth J F Loos, Kari E North
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006719 (2017)
Genome-wide association studies (GWAS) have identified >300 loci associated with measures of adiposity including body mass index (BMI) and waist-to-hip ratio (adjusted for BMI, WHRadjBMI), but few have been identified through screening of the African
Externí odkaz:
https://doaj.org/article/812905a1eb094c909263039fcfc51f1f
Autor:
Joshua C Bis, Colleen Sitlani, Ryan Irvin, Christy L Avery, Albert Vernon Smith, Fangui Sun, Daniel S Evans, Solomon K Musani, Xiaohui Li, Stella Trompet, Bouwe P Krijthe, Tamara B Harris, P Miguel Quibrera, Jennifer A Brody, Serkalem Demissie, Barry R Davis, Kerri L Wiggins, Gregory J Tranah, Leslie A Lange, Nona Sotoodehnia, David J Stott, Oscar H Franco, Lenore J Launer, Til Stürmer, Kent D Taylor, L Adrienne Cupples, John H Eckfeldt, Nicholas L Smith, Yongmei Liu, James G Wilson, Susan R Heckbert, Brendan M Buckley, M Arfan Ikram, Eric Boerwinkle, Yii-Der Ida Chen, Anton J M de Craen, Andre G Uitterlinden, Jerome I Rotter, Ian Ford, Albert Hofman, Naveed Sattar, P Eline Slagboom, Rudi G J Westendorp, Vilmundur Gudnason, Ramachandran S Vasan, Thomas Lumley, Steven R Cummings, Herman A Taylor, Wendy Post, J Wouter Jukema, Bruno H Stricker, Eric A Whitsel, Bruce M Psaty, Donna Arnett
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140496 (2015)
Hypertension is a major risk factor for a spectrum of cardiovascular diseases (CVD), including myocardial infarction, sudden death, and stroke. In the US, over 65 million people have high blood pressure and a large proportion of these individuals are
Externí odkaz:
https://doaj.org/article/4783d750331d4a3ebd7298fdecd6c1fc