Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Leslie, Magtanong"'
Autor:
Marcos A Perez, Andrea J Clostio, Isabel R Houston, Jimena Ruiz, Leslie Magtanong, Scott J Dixon, Jennifer L Watts
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010436 (2022)
Ferroptosis is an iron-dependent form of regulated cell death associated with uncontrolled membrane lipid peroxidation and destruction. Previously, we showed that dietary dihomo-gamma-linolenic acid (DGLA; 20: 3(n-6)) triggers ferroptosis in the germ
Externí odkaz:
https://doaj.org/article/f14d29c6a8ee4ec9ac1b3a16c9ec8484
Autor:
Amy Tarangelo, Leslie Magtanong, Kathryn T. Bieging-Rolett, Yang Li, Jiangbin Ye, Laura D. Attardi, Scott J. Dixon
Publikováno v:
Cell Reports, Vol 22, Iss 3, Pp 569-575 (2018)
How cancer cells respond to nutrient deprivation remains poorly understood. In certain cancer cells, deprivation of cystine induces a non-apoptotic, iron-dependent form of cell death termed ferroptosis. Recent evidence suggests that ferroptosis sensi
Externí odkaz:
https://doaj.org/article/65fa87ec72d24c9a89ee70935269d022
Autor:
Jennifer Yinuo Cao, Aunoy Poddar, Leslie Magtanong, Jennifer H. Lumb, Trevor R. Mileur, Michael A. Reid, Cole M. Dovey, Jin Wang, Jason W. Locasale, Everett Stone, Susan P.C. Cole, Jan E. Carette, Scott J. Dixon
Publikováno v:
Cell Reports, Vol 26, Iss 6, Pp 1544-1556.e8 (2019)
Summary: The tripeptide glutathione suppresses the iron-dependent, non-apoptotic cell death process of ferroptosis. How glutathione abundance is regulated in the cell and how this regulation alters ferroptosis sensitivity is poorly understood. Using
Externí odkaz:
https://doaj.org/article/c62f1fcca97a4f38a038ca65ecfdfe8f
Autor:
Zhipeng Li, Lucas Ferguson, Kirandeep K. Deol, Melissa A. Roberts, Leslie Magtanong, Joseph M. Hendricks, Gergey Alzaem Mousa, Seda Kilinc, Kaitlin Schaefer, James A. Wells, Michael C. Bassik, Andrei Goga, Scott J. Dixon, Nicholas T. Ingolia, James A. Olzmann
Publikováno v:
Nature chemical biology, vol 18, iss 7
The selenoprotein glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid peroxides into nontoxic lipid alcohols. GPX4 has emerged as a promising therapeutic target for cancer treatment, but some cancer cells are resistant to ferropt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2096209c46df26a9ae0bef17401800c0
https://escholarship.org/uc/item/80v3t2bt
https://escholarship.org/uc/item/80v3t2bt
Autor:
David A. Armenta, Megan Conlon, Alexis Kahanu, Alex Wells, Carson D. Poltorack, Melodie Mallais, Derek A. Pratt, Leslie Magtanong, Giovanni C. Forcina, Marcos A. Perez, Jennifer L. Watts, Scott J. Dixon
Publikováno v:
Nature chemical biology
Cell death can be executed by regulated apoptotic and non-apoptotic pathways, including the iron-dependent process of ferroptosis. Small molecules are essential tools for studying the regulation of cell death. Using time-lapse imaging, and a library
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7e5144f23320284802f7e470cb9d5f
https://doi.org/10.1038/s41589-021-00751-4
https://doi.org/10.1038/s41589-021-00751-4
Autor:
Zhipeng Li, Lucas Ferguson, Kirandeep K. Deol, Melissa A. Roberts, Leslie Magtanong, Michael C. Bassik, Scott J. Dixon, Nicholas T. Ingolia, James A. Olzmann
Ferroptosis is a regulated, iron-dependent form of necrosis that is triggered by the accumulation of oxidatively damaged phospholipids1–3. Glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting phospholipid hydroperoxides into non-toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52dc46b14a416d6a16083ef5297bb128
https://doi.org/10.1101/2022.04.11.487892
https://doi.org/10.1101/2022.04.11.487892
Autor:
Zhipeng, Li, Lucas, Ferguson, Kirandeep K, Deol, Melissa A, Roberts, Leslie, Magtanong, Joseph M, Hendricks, Gergey Alzaem, Mousa, Seda, Kilinc, Kaitlin, Schaefer, James A, Wells, Michael C, Bassik, Andrei, Goga, Scott J, Dixon, Nicholas T, Ingolia, James A, Olzmann
Publikováno v:
Nature chemical biology. 18(7)
The selenoprotein glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid peroxides into nontoxic lipid alcohols. GPX4 has emerged as a promising therapeutic target for cancer treatment, but some cancer cells are resistant to ferropt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c239d0daa7ffe67d3898119d809fd9f
https://pubmed.ncbi.nlm.nih.gov/35713354
https://pubmed.ncbi.nlm.nih.gov/35713354
Autor:
Leslie Magtanong, Grace D. Mueller, Kevin J. Williams, Maximilian Billmann, Katherine Chan, David A. Armenta, Lauren E. Pope, Jason Moffat, Charles Boone, Chad L. Myers, James A. Olzmann, Steven J. Bensinger, Scott J. Dixon
Publikováno v:
Cell chemical biology. 29(9)
Ferroptosis is an important mediator of pathophysiological cell death and an emerging target for cancer therapy. Whether ferroptosis sensitivity is governed by a single regulatory mechanism is unclear. Here, based on the integration of 24 published c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba942fc9ce7a0a6c70c628fef4802afa
https://pubmed.ncbi.nlm.nih.gov/36270234
https://pubmed.ncbi.nlm.nih.gov/36270234
Publikováno v:
Life science alliance. 5(4)
Nucleotide synthesis is a metabolically demanding process essential for DNA replication and other processes in the cell. Several anticancer drugs that inhibit nucleotide metabolism induce apoptosis. How inhibition of nucleotide metabolism impacts non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfa0452160952e2eed23b319b774e69
https://pubmed.ncbi.nlm.nih.gov/35074928
https://pubmed.ncbi.nlm.nih.gov/35074928
Autor:
Leslie Magtanong, Scott J. Dixon
Publikováno v:
Developmental Neuroscience. 40:382-395
Ferroptosis is a nonapoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid reactive oxygen species. Small-molecule screening and subsequent optimization have yielded potent and specific activators and inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ceae83d6ec9d7ab14a5da45ccead4a
https://doi.org/10.1159/000496922
https://doi.org/10.1159/000496922