Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Lesli A Kiedrowski"'
Autor:
Ibiayi Dagogo-Jack, MD, Lesli A. Kiedrowski, MS, MPH, Rebecca S. Heist, MD, MPH, Jessica J. Lin, MD, Catherine B. Meador, MD, PhD, Elizabeth A. Krueger, NP, Andrew Do, BS, Jennifer Peterson, BS, Lecia V. Sequist, MD, MPH, Justin F. Gainor, MD, Jochen K. Lennerz, MD, PhD, Subba R. Digumarthy, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 8, Pp 100534- (2023)
Introduction: MET amplification is a potentially actionable resistance mechanism in ALK-rearranged (ALK+) lung cancer. Studies describing treatment outcomes of this molecular subgroup are lacking. Methods: We assembled a cohort of patients with ALK+
Externí odkaz:
https://doaj.org/article/48f3d6a56b8d4f66bc9f438add97a0a8
Autor:
Umang Swami, Raquel Mae Zimmerman, Roberto H. Nussenzveig, Edgar Javier Hernandez, Yeonjung Jo, Nicolas Sayegh, Sergiusz Wesolowski, Lesli A. Kiedrowski, Pedro C. Barata, Gordon Howard Lemmon, Mehmet A. Bilen, Elisabeth I. Heath, Lakshminarayan Nandagopal, Hani M. Babiker, Sumanta K. Pal, Michael Lilly, Benjamin L. Maughan, Benjamin Haaland, Mark Yandell, Oliver Sartor, Neeraj Agarwal
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BRCA1-mutated prostate cancer has been shown to be less responsive to poly (ADP-ribose) polymerase (PARP) inhibitors as compared to BRCA2-mutated prostate cancer. The reason for this differential response is not clear. We hypothesized this differenti
Externí odkaz:
https://doaj.org/article/4e03b0f2c01f46158e4c977641bd2a04
Autor:
Doreen A. Ezeife, Eldon Spackman, Rosalyn A. Juergens, Janessa J. Laskin, Jason S. Agulnik, Desiree Hao, Scott A. Laurie, Jennifer H. Law, Lisa W. Le, Lesli A. Kiedrowski, Barbara Melosky, Frances A. Shepherd, Victor Cohen, Paul Wheatley-Price, Rachel Vandermeer, Janice J. Li, Roxanne Fernandes, Aria Shokoohi, Richard B. Lanman, Natasha B. Leighl
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Background: Liquid biopsy (LB) can detect actionable genomic alterations in plasma circulating tumor circulating tumor DNA beyond tissue testing (TT) alone in advanced non-small cell lung cancer (NSCLC) patients. We estimated the cost-effectiveness o
Externí odkaz:
https://doaj.org/article/a8d487bdfc16404a9f1aade6c7be2b14
Autor:
Stephen R. Fairclough, Lesli A. Kiedrowski, Jessica J. Lin, Ori Zelichov, Gabi Tarcic, Thomas E. Stinchcombe, Justin I. Odegaard, Richard B. Lanman, Alice T. Shaw, Rebecca J. Nagy
Publikováno v:
Experimental Hematology & Oncology, Vol 8, Iss 1, Pp 1-6 (2019)
Abstract Cell-free DNA (cfDNA) next-generation sequencing has the potential to capture tumor heterogeneity and genomic evolution under treatment pressure in a non-invasive manner. Here, we report the detection of EGFR L792 mutations, a non-covalent m
Externí odkaz:
https://doaj.org/article/a2642d01b2c14be0a9b216a7597b136a
Autor:
Pooja Ghatalia, Chad H. Smith, Arthur Winer, Jiangtao Gou, Lesli A. Kiedrowski, Michael Slifker, Patricia D. Saltzberg, Nicole Bubes, Fern M. Anari, Vineela Kasireddy, Asya Varshavsky, Yang Liu, Eric A. Ross, Wafik S. El-Deiry
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/9c804ce9d16d42729bad19281f05a164
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
The oral poly(adenosine diphosphate-ribose) polymerase inhibitor olaparib is approved for the treatment of patients with human epidermal growth factor 2-negative (HER2−) metastatic breast cancer (mBC) and a germline breast cancer susceptibility gen
Externí odkaz:
https://doaj.org/article/d1b93808853d4a9db0c647136428463f
Publikováno v:
Heliyon, Vol 6, Iss 5, Pp e03841- (2020)
Background: Reversion mutations of somatic BRCA mutations are an important source of resistance within ovarian cancer. Furthermore, these reversion mutations are known to change over the course of treatment. Better understanding of the mechanisms lea
Externí odkaz:
https://doaj.org/article/b27777be51ee420083590ccb8e9feb47
Autor:
David E Piccioni, Achal Singh Achrol, Lesli A Kiedrowski, Kimberly C Banks, Najee Boucher, Garni Barkhoudarian, Daniel F Kelly, Tiffany Juarez, Richard B Lanman, Victoria M Raymond, Minhdan Nguyen, Judy D Truong, Annie Heng, Jaya Gill, Marlon Saria, Sandeep C Pingle, Santosh Kesari
Publikováno v:
CNS Oncology, Vol 8, Iss 2 (2019)
Aim: Genomically matched trials in primary brain tumors (PBTs) require recent tumor sequencing. We evaluated whether circulating tumor DNA (ctDNA) could facilitate genomic interrogation in these patients. Methods: Data from 419 PBT patients tested cl
Externí odkaz:
https://doaj.org/article/ef6262da7ada4d6092de61d74bc2de20
Autor:
Yoshihisa Kobayashi, Chhayheng Chhoeu, Jiaqi Li, Kristin S. Price, Lesli A. Kiedrowski, Jamie L. Hutchins, Aaron I. Hardin, Zihan Wei, Fangxin Hong, Magda Bahcall, Prafulla C. Gokhale, Pasi A. Jänne
Publikováno v:
Nature. 603:335-342
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfde2ae8f9187c19b713a9b29acbc6c2
https://doi.org/10.1038/s41586-022-04451-4
https://doi.org/10.1038/s41586-022-04451-4
Autor:
Ryan B. Corcoran, Rebecca S. Heist, Aaron N. Hata, Liron Bar-Peled, Giulia Siravegna, Jochen K. Lennerz, Samuel J. Klempner, Justin F. Gainor, Dejan Juric, Islam Baiev, Mustafa Sakhi, Katerina A. Fella, Mohammed U. Syed, Alexa G. Michel, Lesli A. Kiedrowski, Junbing Zhang, Meagan B. Ryan, Chendi Li, Jessica J. Lin, Noritaka Tanaka
Mutant-selective KRASG12C inhibitors, such as MRTX849 (adagrasib) and AMG 510 (sotorasib), have demonstrated efficacy in KRASG12C-mutant cancers, including non–small cell lung cancer (NSCLC). However, mechanisms underlying clinical acquired resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6aa2acd4b997a9e54783ae8dd826d4
https://doi.org/10.1158/2159-8290.c.6549266
https://doi.org/10.1158/2159-8290.c.6549266
