Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Lesleyann Hawthorn"'
Autor:
John K. Cowell, LesleyAnn Hawthorn, Chang-Sheng Chang, Eiko Kitamura, Jeane Silva, Haiyan Qin, Rebecca Wang, Sumin Lu, Yating Chong, Tianxiang Hu
The development of myeloid and lymphoid neoplasms related to overexpression of FGFR1 kinases as a result of chromosome translocations depends on the promotion of a stem cell phenotype, suppression of terminal differentiation, and resistance to apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c0e198ede7e5af92cee0f35b0f0cd5d
https://doi.org/10.1158/0008-5472.c.6510396.v1
https://doi.org/10.1158/0008-5472.c.6510396.v1
Autor:
John K. Cowell, LesleyAnn Hawthorn, Chang-Sheng Chang, Eiko Kitamura, Jeane Silva, Haiyan Qin, Rebecca Wang, Sumin Lu, Yating Chong, Tianxiang Hu
Supplemental Figure 1 defining the immunophenotypes of SCLL cell lines used in this study. Supplemental figure 2 describes normalized miR339 and FGFR1 expression levels in normal B-cells and CLL compared with ALL. Supplemental figure 3 describes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081ad453eea919eb5994940dc7e734d7
https://doi.org/10.1158/0008-5472.22419501
https://doi.org/10.1158/0008-5472.22419501
Autor:
John K. Cowell, LesleyAnn Hawthorn, Chang-Sheng Chang, Eiko Kitamura, Jeane Silva, Haiyan Qin, Rebecca Wang, Sumin Lu, Yating Chong, Tianxiang Hu
Summary of predicted targets of miR-339-5p using TargetScan, ,iRDB and miRWalk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402b80a25f6888f501f61606cfcc3ec9
https://doi.org/10.1158/0008-5472.22419498.v1
https://doi.org/10.1158/0008-5472.22419498.v1
Autor:
Muthusamy Thangaraju, Vadivel Ganapathy, Puttur D. Prasad, Lesleyann Hawthorn, Pamela M. Martin, Nagendra Singh, Ling Lan, Ravi N. Padia, Sudha Ananth, Sabarish Ramachandran, Rajneesh Pathania, Selvakumar Elangovan
PDF file - 548K, Supplementary Table S1- Primers used for the RT-PCR assays. Figure S1. DNA methylation inhibitor re-activates GPR109A expression in human breast cancer cells. Figure S2. Stable expression of GPR109A in human breast cancer cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3238a67b552f6a59b1cc39ab61cf0db0
https://doi.org/10.1158/0008-5472.22402472.v1
https://doi.org/10.1158/0008-5472.22402472.v1
Autor:
Muthusamy Thangaraju, Vadivel Ganapathy, Puttur D. Prasad, Lesleyann Hawthorn, Pamela M. Martin, Nagendra Singh, Ling Lan, Ravi N. Padia, Sudha Ananth, Sabarish Ramachandran, Rajneesh Pathania, Selvakumar Elangovan
XLSX file - 43K, Supplementary Table 4 contains the top 100 down regulated genes that are differentially expressed in MB231-pCDH and MB231-GPR109A stable clones in the presence and absence of niacin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13e60445bfc90730061d21cfb232769
https://doi.org/10.1158/0008-5472.22402460.v1
https://doi.org/10.1158/0008-5472.22402460.v1
Autor:
Muthusamy Thangaraju, Vadivel Ganapathy, Puttur D. Prasad, Lesleyann Hawthorn, Pamela M. Martin, Nagendra Singh, Ling Lan, Ravi N. Padia, Sudha Ananth, Sabarish Ramachandran, Rajneesh Pathania, Selvakumar Elangovan
XLSX file - 42K, Supplementary Table 3 contains the top 100 upregulated genes that are differentially expressed in MB231-pCDH and MB231-GPR109A stable clones in the presence and absence of niacin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cf0a4850fcca67febc4d87e9af661d
https://doi.org/10.1158/0008-5472.22402466.v1
https://doi.org/10.1158/0008-5472.22402466.v1
Autor:
Muthusamy Thangaraju, Vadivel Ganapathy, Puttur D. Prasad, Lesleyann Hawthorn, Pamela M. Martin, Nagendra Singh, Ling Lan, Ravi N. Padia, Sudha Ananth, Sabarish Ramachandran, Rajneesh Pathania, Selvakumar Elangovan
XLSX file - 27K, Supplementary Table 2 contains genes that are differentially expressed in MB231-pCDH and MB231-GPR109A stable clones without niacin treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3683c1d8ae25db4dd594bbd6336aaad5
https://doi.org/10.1158/0008-5472.22402469
https://doi.org/10.1158/0008-5472.22402469
Publikováno v:
Genes & Cancer
Background Wilms tumor is the most common pediatric renal tumor and the fourth most common malignancy in children. Chromosome 16q deletion(del) or loss of heterozygosity (LOH) has been correlated with recurrence and overall poor prognosis, such that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1075955479f505882cbd6d72e66d419c
http://europepmc.org/articles/PMC7805536
http://europepmc.org/articles/PMC7805536
Publikováno v:
Genomics. 112:1167-1172
LGI1 mutations predispose to a rare epilepsy syndrome and when inactivated in mice leads to early onset seizures and premature death. Histopathology of the mature brain soon after birth shows cortical dysplasia in Lgi1 null mice with hypercellularity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63be289da015bcd224b9a40127304c30
https://doi.org/10.1016/j.ygeno.2019.07.001
https://doi.org/10.1016/j.ygeno.2019.07.001
Autor:
Mingqiang Ren, Chang-Sheng Chang, Jeane Silva, Lesleyann Hawthorn, John K. Cowell, Eiko Kitamura, Haiyan Qin, Tianxiang Hu
Publikováno v:
Genomics. 111:1566-1573
Constitutive activation of FGFR1 as a result of chromosome translocations is responsible for the development of a hematopoietic stem cell disorder that progresses to AML. We have developed a syngeneic mouse model of BCR-FGFR1 driven AML and used RNAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c8af3e01f9718c565dee5f8f4060c6
https://doi.org/10.1016/j.ygeno.2018.10.015
https://doi.org/10.1016/j.ygeno.2018.10.015