Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Lesley T MacNeil"'
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007074 (2018)
Type IV pili are expressed by a wide range of prokaryotes, including the opportunistic pathogen Pseudomonas aeruginosa. These flexible fibres mediate twitching motility, biofilm maturation, surface adhesion, and virulence. The pilus is composed mainl
Externí odkaz:
https://doaj.org/article/52d601ba39dc496d8b761b2dc2181939
Autor:
Yuwei Jiang, Lesley T. MacNeil
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-23 (2023)
Abstract The lack of effective therapies that slow the progression of Alzheimer’s disease (AD) and related tauopathies highlights the need for a more comprehensive understanding of the fundamental cellular mechanisms underlying these diseases. Mode
Externí odkaz:
https://doaj.org/article/ebdd763474174779bd069e51e9f31256
Autor:
H Efsun Arda, Stefan Taubert, Lesley T MacNeil, Colin C Conine, Ben Tsuda, Marc Van Gilst, Reynaldo Sequerra, Lynn Doucette‐Stamm, Keith R Yamamoto, Albertha J M Walhout
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene expression at a systems level. GRNs that relate to metazoan development have been studied extensively. However, little is still known about the design principle
Externí odkaz:
https://doaj.org/article/3a65b7317a6a45a985811f7268e68db3
Autor:
Lesley T. MacNeil
Publikováno v:
Current biology : CB. 32(9)
A new study finds that a bacterium from the microbiome of the nematode Pristionchus pacificus can promote rapid growth, increased body size, and increased fecundity by inducing neuronal expression of TGF-β ligands. This is an intriguing example of h
Publikováno v:
Genetics
Mesbahi et al. find that environmental factors, including diet, starvation, and population density can differentially influence the penetrance of collagen mutant phenotypes. Factors that decrease the penetrance of rolling in dominant... The nematode
Autor:
Queenie Hu, Terrance J. Kubiseski, Albertha J.M. Walhout, Lesley T. MacNeil, Dayana R. D’Amora
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 12, Pp 3857-3863 (2018)
The overproduction of reactive oxygen species (ROS) in cells can lead to the development of diseases associated with aging. We have previously shown that C. elegansBRAP-2 (Brca1 associated binding protein 2) regulates phase II detoxification genes su
Type IVa pili (T4aP) are important virulence factors for many bacterial pathogens. Previous studies suggested that the retraction ATPase, PilT, modulates pathogenicity due to its critical role in pilus dynamics and twitching motility. Here we use a C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34dc9035fe0920859f941fbe22a49f97
https://doi.org/10.1101/2021.01.28.428742
https://doi.org/10.1101/2021.01.28.428742
The nematodeCaenorhabditis elegansis protected from the environment by the cuticle, an extracellular collagen-based matrix that encloses the animal. Over 170 cuticular collagens are predicted in theC. elegansgenome, but the role of each individual co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51823f1c719badf67d9058bd594f55d
https://doi.org/10.1101/2020.03.06.980656
https://doi.org/10.1101/2020.03.06.980656
Autor:
Jennifer T. Lau, Michael G. Surette, Julie Perry, Gerard D. Wright, Austin Yan, Lesley T. MacNeil, Elizabeth J. Culp
Publikováno v:
ACS Infectious Diseases. 4:68-76
Bacteria living in the human gut are implicated in the etiology of several diseases. Moreover, dozens of drugs are metabolized by elements of the gut microbiome, which may have further implications for human health. Here, we screened a collection of
Autor:
Albertha J.M. Walhout, Queenie Hu, Terrance J. Kubiseski, Lesley T. MacNeil, Dayana R. D’Amora
Publikováno v:
Genetics. 206:1909-1922
Cellular damage caused by reactive oxygen species is believed to be a major contributor to age-associated diseases. Previously, we characterized the Caenorhabditis elegans Brap2 ortholog (BRAP-2) and found that it is required to prevent larval arrest