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Autor:
Scott Mead, Lesley Sheffield, André B.P. van Kuilenburg, Andrew Cameron, Ross Norris, Marion Harris, Bruce G. Charles, Rani George, Ming Ni, Catherine Shannon, John A. Duley, Nuala A. Helsby
Publikováno v:
European journal of pharmaceutical sciences, 81, 36-41. Elsevier
The fluoropyrimidine drugs 5-fluorouracil and its oral prodrug capecitabine remain first line therapy for solid tumours of the neck, breast and colon. However, significant and unpredictable toxicity affects about 10–25% of patients depending upon t